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Dietary supplement

Natural Vitamin K-2 Bioactive Form Ingredients & Drug Interactions

by Vitamin World

Natural Vitamin K-2 Bioactive Form label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Vitamin K-2 Bioactive Form against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Natural Vitamin K-2 Bioactive Form is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Vitamin K-2 Bioactive Form by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Vitamin K-2 Bioactive Form by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Vitamin K-2 Bioactive Form by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin K-2 in its bioactive form. Vitamin K is a fat-soluble vitamin that plays a key role in blood clotting and bone health.

The softgel capsule also holds sunflower seed oil, gelatin, and vegetable glycerin as inactive ingredients to deliver the vitamin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Bone health and blood clotting support.
  • We looked for evidence on: Hemorrhagic disease, Hypoprothrombinemia, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation, Osteoporosis, Cardiovascular disease (CVD) — and 3 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K-2 is rated effective for correcting vitamin K deficiency disorders — hypoprothrombinemia (a clotting problem), vitamin K-dependent clotting factor deficiency, and hemorrhagic disease (abnormal bleeding). It's also rated effective for managing warfarin anticoagulation when prescribed by a doctor.

For osteoporosis, the evidence is listed as possibly effective, meaning there's some promise but it's not conclusive.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, vitamin K is generally well tolerated. The most common side effects are mild gastrointestinal upset — nausea, diarrhea, and stomach upset — though most people don't experience them.

Vitamin K is rated likely safe during pregnancy and lactation. That said, the safety notes advise checking with your doctor before taking supplements, even though normal dietary amounts are fine.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin (Coumadin) or any blood thinner medication. Vitamin K can reduce how well these drugs work, and your dose may need adjustment or you may need closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Natural Vitamin K-2 works best if you're correcting a vitamin K deficiency or supporting bone health under a doctor's care. If you take warfarin or other blood thinners, this supplement is not for you without explicit approval from your doctor or pharmacist — vitamin K can make those medications less effective.

Talk with your own healthcare provider before starting to make sure it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Vitamin K-2 Bioactive Form, straight from the product label.

Brand Vitamin World
Barcode (UPC) 766443178750
Net contents 30 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 64687
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Vitamin K-2 Bioactive Form by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766443178750
IngredientAmount% DV
Vitamin K-250 mcg63%

Other ingredients: Sunflower seed Oil, Gelatin, Vegetable Glycerin, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Quality Assured

Brand IP Statement(s)

At Vitamin World we ensure the quality of all of our premium nutritional products, every step of the way. Strict quality analysis at our world-class facilities guarantees that all Vitamin World products are at the highest standard of potency and purity.

2016 Vitamin World, Inc.

Nutrition from the source

Menaq7 is a registered trademark of NattoPharma ASA, Norway.

Formulation

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains soy ingredients.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

To reorder prod. #17875 www.vitaminworld.com 1-800-228-4533

Bioactive form

Promotes bone mass & strength

Vitamin K-2, also known as Menaquinone, supports normal blood clotting in the body. K-2 also activates enzymes responsible for bone formation. This bioactive nutrient helps maintain bone mass and promote bone health.

General

Product No. 17875 B17875 03C

Formula

Menaq7 (menaquinone-7) Natural Vitamin K2

Vitamin K

Contains soy ingredients.

Unlike synthetic forms of Vitamin K, our K-2 is derived from a unique form of soy known in Japan as natto.

FDA Statement of Identity

Vitamin Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel daily, preferably with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Vitamin K-2 Bioactive Form by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Vitamin K-2 Bioactive Form label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Vitamin K-2 Bioactive Form by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Vitamin K-2

Interacts with
2 drugs
50 mcg per serving Form: MenaQ7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K-2 monograph & interactions

Other (inactive) ingredients: Sunflower seed Oil, Gelatin, Vegetable Glycerin, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Vitamin K-2 Bioactive Form by Vitamin World Drug Interactions

Want to check YOUR meds against Natural Vitamin K-2 Bioactive Form?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K-2 2

Individual Drug Interactions

The ingredients in Natural Vitamin K-2 Bioactive Form interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Vitamin K-2 Bioactive Form interact with drugs. Each result below shows which ingredient is responsible. Vitamin K-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Vitamin K-2 Bioactive Form with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K-21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Vitamin K-2 Bioactive Form, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Natural Vitamin K-2 Bioactive Form by Vitamin World: Common Questions

Does Natural Vitamin K-2 Bioactive Form by Vitamin World interact with any medications?
Yes. Based on its ingredients, Natural Vitamin K-2 Bioactive Form has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Vitamin K-2 Bioactive Form contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No — not without talking to your doctor first. Vitamin K can weaken warfarin's effect and increase your clot risk. Your doctor or pharmacist needs to know before you start this supplement.
What are the most common side effects?
Taken by mouth, vitamin K is usually well tolerated. Some people experience mild nausea, diarrhea, or stomach upset, but these aren't common.
Is this safe during pregnancy?
Vitamin K is rated likely safe in pregnancy and lactation. Still, talk with your doctor or midwife before taking any supplement during pregnancy to make sure it's right for you.
What is vitamin K-2 used for?
Vitamin K-2 supports blood clotting and bone health. It's proven effective for correcting vitamin K deficiency disorders and managing warfarin therapy under medical supervision. For osteoporosis, the evidence is promising but not yet conclusive.
Does this product contain any fillers?
The softgel capsule includes sunflower seed oil, gelatin, and vegetable glycerin as inactive ingredients to deliver the vitamin. These are typical for this type of supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Vitamin K-2 Bioactive Form is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Vitamin K-2 Bioactive Form label
Go deeper

The Full Monographs Behind Natural Vitamin K-2 Bioactive Form’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Natural Vitamin K-2 Bioactive Form's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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