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Dietary supplement

Vitamin K2 100 mcg Ingredients & Drug Interactions

by Bluebonnet

Vitamin K2 100 mcg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K2 100 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K2 100 mcg is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K2 100 mcg by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K2 100 mcg by Bluebonnet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K2 100 mcg by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: vitamin K2 at 100 micrograms per capsule. Vitamin K2 is a form of vitamin K that plays a role in bone metabolism and blood clotting.

The capsule also contains inactive ingredients — cellulose, hypromellose, purified water, and magnesium stearate — which are common fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support strong healthy bones and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Bone density, Vascular calcification.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Vitamin K-dependent clotting factors deficiency (VKCFD) (Natural Medicines).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).

Vitamin K2 is effective for treating vitamin K deficiency and related clotting disorders. The evidence supports its use for hypoprothrombinemia (a condition where the blood doesn't clot well), vitamin K-dependent clotting factor deficiency, correction of warfarin anticoagulation (reversing blood thinner effects when needed medically), and hemorrhagic disease (serious bleeding).

For osteoporosis, the evidence is possibly effective — meaning there's some supporting data, but it's not yet conclusive.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K2 is generally well tolerated in the amounts found in food and most supplements if you're a healthy adult without any clotting disorders or medications that interact with it. The most common side effects are mild gastrointestinal upset: nausea, diarrhea, stomach pain, and general stomach upset happen in some people.

Serious side effects are rare with oral supplements. Because vitamin K can affect blood clotting, you should check with your doctor before taking supplements — dietary amounts are fine, but supplements are a different story.

In pregnancy and lactation, vitamin K2 is rated likely safe.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, this is your big one: vitamin K2 can reduce how well your medication works by interfering with its anticoagulant effect. Check with your doctor or pharmacist before starting this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a straightforward single-ingredient supplement useful if you have a documented vitamin K deficiency or your doctor has recommended it for bone health. If you take warfarin or any other blood thinner, do not start this without clearing it first — the interaction is serious and could reduce your medication's effectiveness.

Talk to your pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K2 100 mcg, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715006522
Net contents 50 Vegetable Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 332794
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), No Allergies
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K2 100 mcg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
50
UPC/BARCODE
743715006522
IngredientAmount% DV
Vitamin K2100 mcg--

Other ingredients: Cellulose, Hypromellose, Water, Purified, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bluebonnet's Vitamin K2 100 mcg vegetable capsules are formulated with vitamin K2 (menaquinone-7) produced from fermentation using Bacillus subtilis natto cultures to help support strong, healthy bones and heart health.

Bluebonnet's KOF-K Certification #K-0000700

KOF-K Parve (Kosher)

Formulation

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of gluten, barley, rice, sodium and sugar.

Made with non GMO ingredients

Bone & heart health

Vegan

Made with non GMO ingredients Gluten free Soy free

Precautions

Caution: Do not use this product if you are pregnant, trying to conceive or breastfeeding. If you are taking prescription medication, speak to your healthcare practitioner before use. Do not use this supplement with blood-thinning medication.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made with non GMO ingredients Vegan KOF-K Parve (Kosher)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily, preferably with a meal or as directed by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K2 100 mcg by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K2 100 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K2 100 mcg by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
100 mcg per serving Form: Menaquinone-7, Natto Extract

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Water, Purified, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K2 100 mcg by Bluebonnet Drug Interactions

Want to check YOUR meds against Vitamin K2 100 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Vitamin K2 100 mcg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K2 100 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K2 100 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K2 100 mcg, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
bluebonnetnutrition.com
Pharmacist Counseling Corner

Vitamin K2 100 mcg by Bluebonnet: Common Questions

Does Vitamin K2 100 mcg by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Vitamin K2 100 mcg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K2 100 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my bones?
Vitamin K2 is possibly effective for osteoporosis — there's some evidence supporting its use, but the data isn't conclusive yet. Talk with your doctor about whether it makes sense for your specific situation.
What are the side effects?
When taken by mouth, the most common side effects are mild gastrointestinal ones: nausea, diarrhea, stomach pain, and general stomach upset. Serious side effects are rare with oral supplements.
Is it safe in pregnancy?
Vitamin K2 is rated likely safe in pregnancy and lactation, though as always, you should mention it to your doctor or midwife.
Can I take it with my other medications?
That depends entirely on what you're taking. Warfarin (Coumadin) and vitamin K2 don't mix well — vitamin K can reverse the blood thinner's effects. Use the interaction checker on this page to verify your specific medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K2 100 mcg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K2 100 mcg label
Go deeper

The Full Monographs Behind Vitamin K2 100 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K2 100 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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