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Dietary supplement

Nature's Noni Ingredients & Drug Interactions

by Nature's Sunshine

Nature's Noni label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nature's Noni against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nature's Noni is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for general wellness and energy, inflammation and joint pain, immune support.Based on those ingredients, 614 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Noni, Morinda. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nature's Noni by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Nature's Noni by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nature's Noni by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (900 mg) without saying how much of each component you get.

Nature's Noni contains two active ingredients: noni and morinda (also known as ba ji tian). These are herbal components packaged in a proprietary blend formula.

The product also contains inactive ingredients — a capsule and maltodextrin — that help deliver the active herbs.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive, intestinal, respiratory and immune support.
  • We looked for evidence on: Common cold, Cough, Gastrointestinal health, Respiratory health.
  • The closest evidence on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Common cold (Natural Medicines).
  • Also on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Cough.

The evidence for noni in our data is limited. For the conditions listed — asthma, atherosclerosis, athletic performance, burns, cancer, and cardiovascular disease — there is insufficient reliable evidence to rate how well noni works.

Morinda shows possibly effective evidence for depression, though human studies remain limited. If you're considering this product for a specific health concern, talk with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Noni Ba Ji Tian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni is generally well tolerated in moderate amounts, but there are real concerns worth knowing about. Rare cases of serious liver damage have been reported in people taking noni products — some used juice, others herbal teas or drinks containing noni alongside other herbs.

Most common mild side effects are abdominal discomfort and nausea. Because noni has traditionally been used to cause abortion, it should not be used during pregnancy.

Morinda has limited human safety data and should also be avoided in pregnancy and while breastfeeding. If you have liver disease or are at risk for it, discuss this product with your doctor before starting.

Side effects, ingredient by ingredient Noni Ba Ji Tian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Ba Ji Tian, Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 615 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nature's Noni, double-check with your pharmacist or doctor if you take blood pressure drugs (especially ACE inhibitors, ARBs, or potassium-sparing diuretics), blood thinners like warfarin, anti-seizure drugs like phenytoin, diabetes medications, or any drugs that could affect your liver. The potassium content and liver concerns are the biggest red flags.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nature's Noni is best avoided if you take blood pressure medications, blood thinners, seizure drugs, diabetes medications, or drugs that could damage your liver — the interactions are real and potentially serious. If you're considering it for depression (where morinda shows some promise) or another reason, check your full medication list with your doctor or pharmacist first.

Pregnancy and breastfeeding are off-limits with this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nature's Noni, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904004573
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220283
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nature's Noni by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
099904004573
IngredientAmount% DV
Proprietary Blend900 mg--
Noni0 NP--
Morinda0 NP--

Other ingredients: Capsule, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

010004570115

Product of U.S.A. Herb Specialists Since 1972 Nature's Sunshine Quality, Service, Integrity

Formulation

The fruit-bearing Morinda plants are found in tropical and subtropical regions of the world. Historically, many parts of the plant were used to target the Digestive, Intestinal, Respiratory, and Immune Systems. It is particularly useful today in maintaining healthy skin and creating a feeling of well-being. Nature's Sunshine combines ancient tradition by employing the best information from native folk healers with the most up-to-date herbal scientific research available. Select parts from two morinda species are utilized to ensure maximum health benefits.

Nature's Sunshine uses natural source materials that are subject to color variation.

Overall tonic formula Optimizes benefits for nervous and skeletal systems Supports joint health

Nervous and skeletal system support

Guaranteed Pure

Suggested/Recommended/Usage/Directions

Recommendation Take one or two capsules with a meal three times daily.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Notice: Pregnant or lactating women should consult their health care professional prior to taking this supplement.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Formula

Morinda Citrifolia & Officinalis

FDA Statement of Identity

Herbal Dietary Supplement

Brand IP Statement(s)

2015 NSP, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nature's Noni by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nature's Noni label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nature's Noni by Nature's Sunshine

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

900 mg per serving

Other (inactive) ingredients: Capsule, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nature's Noni by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Nature's Noni?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
614Drugs
613 Moderate 1 Minor

Ingredients driving the most interactions

Noni 542
Morinda 86

Individual Drug Interactions

The ingredients in Nature's Noni interact with 614 drugs. Click any drug to see the details.

2 of the 2 ingredients in Nature's Noni interact with drugs. Each result below shows which ingredient is responsible. Noni Morinda

Each ingredient & the kinds of drugs it affects

For each ingredient in Nature's Noni with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Noni8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Noni full monograph & interactions

Morinda1 drug type · 86 drugs

Antidiabetes Drugs

Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels. Theoretically ba ji tian might have additive effects or attenuate the effects antidiabetes drugs. Monitor blood glucose levels closely; dose adjustments of antidiabetes drugs might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Morinda full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nature's Noni, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Nature's Noni by Nature's Sunshine: Common Questions

Does Nature's Noni by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Nature's Noni has a known interaction with 614 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nature's Noni contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not safely without checking first. Noni may lower blood pressure further and raise potassium to risky levels, especially with ACE inhibitors, ARBs, or water pills. Talk with your doctor or pharmacist about your specific blood pressure drugs before starting.
Is noni safe for my liver?
Noni is generally well tolerated, but rare cases of serious liver damage — including liver failure — have been reported. It's not clear whether noni itself or contaminants caused these cases, but if you have liver disease or take other medications that stress your liver, discuss this product with your doctor first.
What are the side effects?
Most common are mild: abdominal discomfort and nausea. Serious liver injury is rare but has been documented. High-quality studies of adverse effects haven't been done, so we don't have a complete picture of how often side effects occur.
Can I take this while pregnant or breastfeeding?
No. Noni has traditionally been used to cause abortion, so avoid it in pregnancy. There isn't enough safety information for either noni or morinda during breastfeeding, so skip it then too. Talk with your doctor about safer options.
Does this really work for depression?
Morinda, one ingredient in this blend, shows possibly effective evidence for depression based on our data, but human studies are limited. Ask your doctor or pharmacist whether the evidence is strong enough for your situation and how it compares to other options.
Can I take this with blood thinners?
Not without checking first. One case report showed noni juice made warfarin less effective, which could increase your clot risk. Your doctor or pharmacist needs to review this before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nature's Noni is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nature's Noni label
Go deeper

The Full Monographs Behind Nature's Noni’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph → Herb & supplement monograph

Ba Ji Tian

Interacts with 86 drugs

Ba Ji Tian is a root used in Traditional Chinese Medicine, mostly to 'tonify the kidneys' and support energy, sexual function, and bone health. Modern evidence in humans is very limited, and...

Read the full Ba Ji Tian monograph →
Sources

Sources & How We Checked

Nature's Noni's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Ba Ji Tian 2 references
  1. Soon, Y. Y. and Tan, B. K. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43(2):077-085.
  2. Du Y, Zheng Q, Ou ZH, et al. Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis. Braz J Psychiatry 2021;43(3):306-313. PubMed

See these in context on the Ba Ji Tian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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