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Dietary supplement

Natural Noni 500 mg Ingredients & Drug Interactions

by Spring Valley

Natural Noni 500 mg label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Noni 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Noni 500 mg is a dietary supplement by Spring Valley with 1 active ingredient. Its ingredients are commonly taken for general wellness and energy, inflammation and joint pain, immune support.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Organic Noni. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Noni 500 mg by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Noni 500 mg by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Noni 500 mg by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: 500 mg of organic noni (the noni fruit). Noni is a tropical fruit that's been used traditionally in Pacific Island medicine, and it's marketed here as a whole-fruit extract.

The capsule also holds several inactive ingredients—soybean oil, gelatin, glycerin, yellow beeswax, soy lecithin, and caramel color—which help form and color the softgel.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Noni product and its label doesn't state a use — see Noni's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for noni isn't established in the data we hold. Our monograph rates it as having insufficient reliable evidence across the conditions listed—asthma, atherosclerosis, athletic performance, burns, cancer, and cardiovascular disease.

That means we don't have enough high-quality studies to say whether it works for any of these uses.

The evidence, ingredient by ingredient Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni is generally well tolerated when taken by mouth in moderate amounts, but there are real concerns worth knowing. The most serious is hepatotoxicity—liver injury.

Though studies haven't conclusively proved whether noni itself or contaminants in noni products caused the damage, there are documented cases of liver problems, including liver failure, in patients who took noni juice or products containing it. Symptoms like nausea, abdominal discomfort, and elevated liver function tests appeared between 2 weeks and months after starting.

Noni is traditionally used to cause abortion and should not be used during pregnancy. There isn't enough safety data for lactation either, so it's best avoided while breastfeeding.

The most common side effects from taking it orally are abdominal discomfort and nausea.

Side effects, ingredient by ingredient Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 543 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood pressure or heart medications (antihypertensive drugs, ACE inhibitors, ARBs, potassium-sparing diuretics), blood thinners like warfarin, seizure drugs like phenytoin, liver-stressing medications, or ranitidine for heartburn. Noni interacts with all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Natural Noni may appeal to you if you're interested in traditional herbal remedies, but the evidence for its effectiveness just isn't there yet. More importantly, if you take any blood pressure medication, heart drug, blood thinner, seizure medication, or potassium-affecting diuretic, you need to check this product with your own doctor or pharmacist before starting—the interaction risks are real.

The potential for liver injury, though rare, is another reason to talk it over first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Noni 500 mg, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131928847
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 73332
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Noni 500 mg by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
681131928847
IngredientAmount% DV
Organic Noni500 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, yellow Beeswax, Soy Lecithin, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

GN 2874.72049 Item No. 35371 B36781W 04D

General Statements

Vitamin #1 brand

General wellness

Noni is produced fromfully sun-ripened organic Noni fruits. All the benefits of Noni fruit without the unpleasant taste.

Quality assurance guarantee Produced under strict quality guidelines. Verified by an independent, ISO 9001:2000 certified laboratory. Unconditionally guaranteed by refund or replacement

Formula

Natural Noni 500 mg per serving

FDA Statement of Identity

Dietary Supplement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

No gluten, no yeast, no wheat, no milk or milk derivatives, no lactose, no sugar, no preservatives, no artificial flavor, no sodium (less than 5 mg per serving)

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take two softgels once daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of the reach of children.

For your protection, do not use if seal under cap is broken or missing.

Storage

Store at room temperature. Keep bottle tightly closed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Noni 500 mg by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Noni 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Noni 500 mg by Spring Valley

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Organic Noni

Interacts with
542 drugs
500 mg per serving

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Organic Noni monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Yellow Beeswax, Soy Lecithin, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Noni 500 mg by Spring Valley Drug Interactions

Want to check YOUR meds against Natural Noni 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
542Drugs
541 Moderate 1 Minor

Ingredients driving the most interactions

Organic Noni 542

Individual Drug Interactions

The ingredients in Natural Noni 500 mg interact with 542 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Noni 500 mg interact with drugs. Each result below shows which ingredient is responsible. Organic Noni

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Noni 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Organic Noni8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Organic Noni full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Noni 500 mg, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-866-251-1662
Pharmacist Counseling Corner

Natural Noni 500 mg by Spring Valley: Common Questions

Does Natural Noni 500 mg by Spring Valley interact with any medications?
Yes. Based on its ingredients, Natural Noni 500 mg has a known interaction with 542 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Noni 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take noni if I'm pregnant or breastfeeding?
No. Noni has traditionally been used to cause abortion, so the safety data advises against it during pregnancy. There also isn't enough safety information for breastfeeding, so it's best avoided. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before considering any herbal supplement.
What are the side effects of noni?
The most common ones are abdominal discomfort and nausea. Rare but serious cases of liver injury and liver failure have been reported with noni products, though it's not always clear whether noni itself or contaminants caused the damage. If you develop nausea, belly pain, or signs of liver problems (yellowing skin or eyes, dark urine, unusual tiredness), stop and talk to your doctor right away.
Does noni actually work for what it claims?
We don't have enough reliable evidence to say. Our data rates noni as insufficient evidence for asthma, heart disease, athletic performance, burns, cancer, and other conditions commonly claimed. That doesn't mean it doesn't work—it means the studies just aren't there yet.
Is noni high in potassium?
Yes. Noni juice contains significant potassium, about 6 mEq per 100 mL. That's why it can raise your potassium to unsafe levels if you're on medications like potassium-sparing diuretics, ACE inhibitors, or ARBs. If you have kidney disease or take any of these drugs, this is an important concern to discuss with your doctor.
Why does noni interact with so many blood pressure and heart drugs?
Noni may lower blood pressure on its own, so combining it with blood pressure medications could drop your pressure too far. It's also high in potassium, which can be dangerous if you're on drugs that already raise potassium levels. Your doctor needs to know you're taking it so they can monitor you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Noni 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Noni 500 mg label
Go deeper

The Full Monographs Behind Natural Noni 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Natural Noni 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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