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Dietary supplement

Noni Supreme Ingredients & Drug Interactions

by Puritan's Pride

Noni Supreme label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Noni Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Noni Supreme is a dietary supplement by Puritan's Pride with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, weight loss, energy and vitality.Based on those ingredients, 614 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Noni (Morinda citrifolia) fruit powder and juice concentrate, Acai. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Noni Supreme by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Noni Supreme by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Noni Supreme by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Noni Supreme is a liquid supplement with 2 active ingredients: acai and noni fruit powder and juice concentrate. Acai is a berry concentrate, and noni is a tropical fruit in both powder and juice form.

The product also contains inactive ingredients—purified water, fructose, natural flavors, citric acid, xanthan gum (a thickener), black carrot and black currant concentrates for color, and potassium sorbate and potassium benzoate as preservatives.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for both ingredients in this product is not established. Acai has been studied for aging skin, athletic performance, erectile dysfunction, and high cholesterol, but we don't hold sufficient reliable evidence to rate it for any of these uses.

Noni has been studied for asthma, atherosclerosis, athletic performance, burns, cancer, and heart disease, but the evidence is similarly insufficient to rate its effectiveness for any of them.

The evidence, ingredient by ingredient Acai Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni carries the more serious safety concerns here. It is generally well tolerated in moderate amounts, but rare liver injury has been reported—some patients developed liver damage after consuming noni juice or noni-containing products, with symptoms appearing within 2 to 4 weeks.

Noni should be avoided during pregnancy, as it has been traditionally used to cause abortion. During breastfeeding, there isn't enough safety information, so it's best avoided then too.

Acai as a food is generally well tolerated, but high-dose supplements haven't been well studied in pregnancy or breastfeeding, so caution is advised for both. The most common side effects of noni are abdominal discomfort and nausea.

Side effects, ingredient by ingredient Acai Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Noni, Acai.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 615 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Noni Supreme, check with your doctor or pharmacist if you take ACE inhibitors, ARBs, or potassium-sparing diuretics (blood pressure and heart drugs that raise potassium). Also clear it if you're on warfarin or other blood thinners, seizure medications like phenytoin, diabetes drugs, blood pressure medications in general, or hepatotoxic drugs (medications that can stress the liver).

Ranitidine users should know this product may increase ranitidine levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is intended for general wellness, but the noni content carries real medication interactions—especially with blood pressure drugs, blood thinners, and seizure medications—and a rare risk of liver injury. If you take any prescription medications, especially for high blood pressure, blood clotting, seizures, or diabetes, check with your doctor or pharmacist before starting.

Pregnant and breastfeeding individuals should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Noni Supreme, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077136902
Net contents 32 fl. Oz.; 946 mL
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250800
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Noni Supreme by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capful(s)
Maximum serving Sizes:
1 Capful(s)
Servings per container
32
UPC/BARCODE
025077136902
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Acai1000 mg--
Noni (Morinda citrifolia) fruit powder and juice concentrate9000 mg--

Other ingredients: purified Water, Fructose, Natural flavors, Citric Acid, Xanthan Gum, Black Carrot concentrate, Black Currant concentrate, Potassium Sorbate, Potassium Benzoate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

To reorder item #13690 www.puritan.com 1-800-645-1030

{Traditional fruits of Tahiti & Brazil}

Delicious flavor!

Brand IP Statement(s)

Copyright 2017 Puritan’s Pride, Inc.

Seals/Symbols

QA Quality Assured

Formulation

Triple strength A supreme gift of nature

Vegetarian Dietary Supplement

No artificial flavor, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish.

Puritan’s Pride supplements are produced from the finest raw materials under stringent quality control standards.

State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

Discover healthful gifts from paradise in the goodness of Noni Supreme.

Miles above other noni products, Noni Supreme offers you a health-supporting blend that brings paradise to your door.

Color, texture and taste may vary.

Formula

With acai

Dynamic health blend of noni & acai

This exotic supplement contains noni, which is sourced from Tahiti, Hawaii and India. Noni is a tropical fruit that’s rich in beneficial phytochemicals to support overall health. We also include the Brazilian super fruit acai, a natural source of antioxidants.

FDA Statement of Identity

Vegetarian Dietary Supplement

Suggested/Recommended/Usage/Directions

Shake well!

Directions: For adults, take one (1) capful (1 fl. oz.) (30 mL) daily, preferably before meals.

Shake well before use.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store unopened container at room temperature.

Refrigerate after opening.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Noni Supreme by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Noni Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Noni Supreme by Puritan's Pride

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capful(s) Dosage formLiquid Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acai

Interacts with
86 drugs
1000 mg per serving

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacki...

Acai monograph & interactions

Noni (Morinda citrifolia) fruit powder and juice concentrate

Interacts with
542 drugs
9000 mg per serving

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Noni (Morinda citrifolia) fruit powder and juice concentrate monograph & interactions

Other (inactive) ingredients: Purified Water, Fructose, Natural flavors, Citric Acid, Xanthan Gum, Black Carrot concentrate, Black Currant concentrate, Potassium Sorbate, Potassium Benzoate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Noni Supreme by Puritan's Pride Drug Interactions

Want to check YOUR meds against Noni Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
614Drugs
613 Moderate 1 Minor

Ingredients driving the most interactions

Noni (Morinda citrifolia) fruit powder and juice concentrate 542
Acai 86

Individual Drug Interactions

The ingredients in Noni Supreme interact with 614 drugs. Click any drug to see the details.

2 of the 2 ingredients in Noni Supreme interact with drugs. Each result below shows which ingredient is responsible. Noni (Morinda citrifolia) fruit powder and juice concentrate Acai

Each ingredient & the kinds of drugs it affects

For each ingredient in Noni Supreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Noni (Morinda citrifolia) fruit powder and juice concentrate8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Noni (Morinda citrifolia) fruit powder and juice concentrate full monograph & interactions

Acai1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.

Likelihood Possible Evidence D
Acai full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Noni Supreme, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Noni Supreme by Puritan's Pride: Common Questions

Does Noni Supreme by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Noni Supreme has a known interaction with 614 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Noni Supreme contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is noni safe during pregnancy?
No. Noni should be avoided during pregnancy—it has been traditionally used to cause abortion. The safety data advises against it. Talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to become pregnant.
Can I take this if I'm breastfeeding?
There isn't enough safety information on noni or acai during breastfeeding. The data advises caution or avoidance. Check with your doctor or pharmacist to decide what's right for your situation.
What are the side effects of noni?
The most common side effects are abdominal discomfort and nausea. Rarely, noni has been linked to liver injury, with symptoms appearing as early as 2 to 4 weeks. If you develop upper right abdominal pain, yellowing of skin or eyes, or dark urine, stop and contact your doctor right away.
Does acai actually work for weight loss or cholesterol?
The evidence isn't established. We don't hold sufficient reliable evidence to rate acai for obesity, high cholesterol, or any other use. While it's studied for these purposes, the data we have isn't strong enough to say whether it works.
Why is noni high in potassium a problem?
Noni juice contains significant amounts of potassium. If you take blood pressure or heart medications that also raise potassium—like ACE inhibitors, ARBs, or potassium-sparing diuretics—combining them with noni could push your potassium levels too high, a condition called hyperkalemia that can affect your heart rhythm and be dangerous.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Noni Supreme label
Go deeper

The Full Monographs Behind Noni Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acai

Interacts with 86 drugs

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often atta...

Read the full Acai monograph → Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Noni Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acai 2 references
  1. Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

See these in context on the Acai monograph →

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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