Major interaction on record — check this product against your medications before combining. Based on 6 of 11 ingredients. Check your meds →
Dietary supplement

NOXygen Gummy Bear Ingredients & Drug Interactions

by Purus Labs

NOXygen Gummy Bear label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NOXygen Gummy Bear against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

NOXygen Gummy Bear is a dietary supplement by Purus Labs with 11 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 927 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous, Huperzia serrata extract, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NOXygen Gummy Bear by Purus Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with NOXygen Gummy Bear by Purus Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NOXygen Gummy Bear by Purus Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NOXygen Gummy Bear contains 11 active ingredients. Caffeine anhydrous is a stimulant for mental alertness and physical performance.

Sodium is an essential electrolyte. L-tyrosine is an amino acid your body uses to make neurotransmitters and thyroid hormones.

Beta-alanine is an amino acid that may support athletic performance. Choline supports brain function and comes in two forms here: regular choline and VitaCholine.

Citrulline nitrate supports blood vessel function and nitric oxide production. Huperzia serrata extract contains huperzine A, which affects brain chemistry.

Betaine nitrate also supports nitric oxide pathways. ZumXR is a caffeine compound (so this product contains two caffeine sources).

Hydromax EZ Flow is a hydration ingredient. The product also contains inactive ingredients including malic acid, natural and artificial flavor, silica, sodium bicarbonate, pink Himalayan sea salt, sucralose, and acesulfame potassium.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: athletic performance and muscle pump support.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle breakdown, Exercise-induced muscle soreness, endurance, muscle fatigue — and 1 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance, Physical performance.
  • Also on file: Choline is rated "Possibly Ineffective" for Athletic performance.

The caffeine in this product is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance. L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory.

Beta-alanine is possibly effective for athletic performance and physical performance. Choline's effectiveness is not well established in our data for most uses.

Huperzia serrata extract has no effectiveness ratings in our data. Overall, the product appears positioned mainly for athletic performance and mental alertness, where caffeine and beta-alanine show the strongest evidence.

The evidence, ingredient by ingredient Caffeine Sodium Tyrosine Beta-alanine Choline Toothed Clubmoss

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate amounts is generally well tolerated in healthy adults, but high doses can cause anxiety, insomnia, jitteriness, headache, nausea, tremors, and rarely stroke. Sodium is fine at normal dietary levels but too much is linked to high blood pressure and heart problems.

L-tyrosine is generally well tolerated; common mild side effects include fatigue, headache, heartburn, and nausea. Beta-alanine commonly causes harmless tingling and flushing of the skin, usually starting on the scalp within 20 minutes and lasting about an hour.

Choline is generally safe at normal food amounts but can cause fishy body odor, and at very high doses (9+ grams daily) can cause nausea, vomiting, and diarrhea. Huperzia serrata extract can cause dizziness, nausea, and sweating, and product quality varies widely.

For pregnancy, caffeine is rated possibly safe but also possibly unsafe — talk to your doctor about safe limits. L-tyrosine, beta-alanine, and the toothed clubmoss extract lack sufficient safety data in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Caffeine Sodium Tyrosine Beta-alanine Choline Toothed Clubmoss

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Toothed Clubmoss, Choline, Caffeine, Tyrosine, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 927 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NOXygen Gummy Bear, check with your doctor or pharmacist if you take any of these: stimulants like ephedrine (Major risk), blood pressure or heart medications, seizure medications, antipsychotics, stomach acid reducers, fluoroquinolone antibiotics, sedatives, Parkinson's medication, thyroid hormone, lithium, steroid medications, or anticholinergic or cholinergic drugs. No interactions are documented for the ingredients we could not check, but that absence doesn't guarantee safety.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a stimulant-focused workout and mental performance supplement with caffeine, beta-alanine, and several circulation-supporting ingredients. It's not right for you if you take heart medications, seizure drugs, antipsychotics, sedatives, or blood pressure medications without checking first.

Pregnant or breastfeeding individuals and anyone taking prescription medications should talk with their doctor or pharmacist before starting, since the caffeine and other ingredients may interact or carry safety questions in your particular situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NOXygen Gummy Bear, straight from the product label.

Brand Purus Labs
Barcode (UPC) 850008259197
Net contents 348 Gram(s); 12.3 Ounce(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 292653
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), No Allergies
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NOXygen Gummy Bear by Purus Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
11.6 Gram(s)
Maximum serving Sizes:
11.6 Gram(s)
Servings per container
30
UPC/BARCODE
850008259197
IngredientAmount% DV
Caffeine Anhydrous200 mg--
Calories10 Calorie(s)--
Sodium160 mg7%
Total Carbohydrates2 Gram(s)1%
L-Tyrosine500 mg--
Beta Alanine3200 mg--
Choline300 mg50%
VitaCholine750 mg--
Citrulline Nitrate1000 mg--
Huperzia serrata extract10 mg--
Betaine Nitrate1000 mg--
ZumXR67 mg--
Hydromax EZ Flow1500 mg--

Other ingredients: Malic Acid, Natural and Artificial flavor, Silica, Sodium Bicarbonate, pink Himalayan Sea Salt, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Pump up your performance Purus Labs NOXygen has remained unmatched since its inception in 2013 as a category-defining pre-workout pump additive.

Instant volumization Hydration Clean energy Focus Pump Performance Endurance Unparalleled pump Bloodflow & O2 amplifier

Allergen: none

Formula

N03-T Citrulline Nitrate combined with HydroMax powered glycerol-the cornerstones of NOXygen - are now combined with full does of beta alanine, Vitacholine natural choline bitartrate, and unique and blend of caffeine anhydrous and zumXR extended-release caffeine or smooth, sustained energy release. Rounded out by l-tyrsone and Huperiza serra for focus and pink Himalayan sea salt for hydration NOXygen Preworkout is the formula finally worthy of the NOXyen name.

Gummy bear Natural and artificial flavor

Dietary Supplement with hydromax and no3-T nitrates

NO3T Nitrate Technology Powered by ZumXR VitaCholine

Suggested/Recommended/Usage/Directions

How to use: Mix 1 serving with 8-10 fl. oz. of cold water and consume 20-30 minutes prior to training.

Precautions

NOXygen is intended only for healthy adults above the age of 18.

Do not use this product if you have been diagnosed with or have a family history of (including, but not limited to): heart disease, thyroid disease, liver disease, cancer, Barrett's Esophagus, gastroesophageal reflux, diabetes, hypoglycemia, hypo/hypertension, asthma, any psychiatric condition including depression or seizure disorder, or if you are using any other dietary supplement, prescription drug, or over-the-counter drug intended to promote vasodilation, in particular those intended for erectile dysfunction. The combined use of vasodilatory supplements or drugs and NOXygen could cause an unsafe drop in blood pressure. Do not use if you are currently pregnant or nursing.

Keep out of reach of children.

Warning: Consuming this product can expose you to chemicals including lead which are known to the State of California to cause caner and birth defects or other productive harm. For more information go to www.P65Warnings.cagov/food.

Contains 245mg of caffeine

All individuals should consult a licensed healthcare practitioner before using this product. Discontinue use and contact a medical doctor immediately if you experience an irregular or rapid heart beat, chest pain, shortness of breath, dizziness, lightheadedness, fainting or presyncope, tremors, headache, nausea, or other similar symptoms. If you are a performance athlete and/or subject to drug testing, please ensure compliance with your regulatory body prior to use.

Storage

Store in a cool, dry area away from direct sunlight

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Follow us Facebook.com/Puruslabs Twitter @puruslabs Instagram @puruslabs

30 true servings Nutritional information

Call us at 855.629.6328 or visit us at puruslabs.com

Seals/Symbols

Proudly and safely made in the USA with components and ingredients of domestic and international origin.

FDA Statement of Identity

Dietary Supplement with hydromax and no3-T nitrates

Brand IP Statement(s)

NO3-T is a registered trademark of ThermoLife International, LLC. This mark covers the use of one or more patents listed at http://www.NO3-T.com/patents zumXR is a trademark of Nano Pharmaceuticals Laboratories, LLC. Patents and patents pending. VitaCholine is a trademark of Balchem Corporation.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NOXygen Gummy Bear by Purus Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NOXygen Gummy Bear label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NOXygen Gummy Bear by Purus Labs

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size11.6 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Caffeine Anhydrous

Interacts with
655 drugs
200 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Anhydrous monograph & interactions

Sodium

Interacts with
205 drugs
160 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

L-Tyrosine

Interacts with
21 drugs
500 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Beta Alanine

No known
interactions
3200 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta Alanine monograph & interactions

Choline

Interacts with
16 drugs
300 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

VitaCholine

Interacts with
16 drugs
750 mg per serving Form: Choline L(+) Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

VitaCholine monograph & interactions

Citrulline Nitrate

1000 mg per serving Form: NO3-T

Huperzia serrata extract

Interacts with
219 drugs
10 mg per serving Form: Huperzine A

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. S...

Huperzia serrata extract monograph & interactions

Betaine Nitrate

1000 mg per serving Form: NO3-T

ZumXR

Interacts with
655 drugs
67 mg per serving Form: extended release Caffeine

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

ZumXR monograph & interactions

Hydromax EZ Flow

1500 mg per serving Form: Glycerol, Powder

Other (inactive) ingredients: Malic Acid, Natural and Artificial flavor, Silica, Sodium Bicarbonate, Pink Himalayan Sea Salt, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

NOXygen Gummy Bear by Purus Labs Drug Interactions

Want to check YOUR meds against NOXygen Gummy Bear?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
927Drugs
8 Major 773 Moderate 146 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655
Huperzia serrata extract 219
Sodium 205
L-Tyrosine 21
Choline 16

Individual Drug Interactions

The ingredients in NOXygen Gummy Bear interact with 927 drugs. Click any drug to see the details.

5 of the 11 ingredients in NOXygen Gummy Bear interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous Huperzia serrata extract Sodium L-Tyrosine Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in NOXygen Gummy Bear with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

Huperzia serrata extract2 drug types · 219 drugs

Anticholinergic Drugs

In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine. Theoretically, concurrent use of anticholinergic drugs and toothed clubmoss might decrease the effectiveness of toothed clubmoss or the anticholinergic drug.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Cholinergic Drugs

Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties. Theoretically, concurrent use of toothed clubmoss with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Huperzia serrata extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NOXygen Gummy Bear, from the product label.

Purus Labs

See all Purus Labs products
Name
Purus Labs
Street Address
55 Chastain Rd. NW, Ste. 110
City
Kennesaw
State
GA
ZipCode
30144
Phone Number
855.629.6328
Web Address
Puruslabs.com
Pharmacist Counseling Corner

NOXygen Gummy Bear by Purus Labs: Common Questions

Does NOXygen Gummy Bear by Purus Labs interact with any medications?
Yes. Based on its ingredients, NOXygen Gummy Bear has a known interaction with 927 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NOXygen Gummy Bear contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have a lot of caffeine?
Yes — NOXygen Gummy Bear contains caffeine anhydrous and also ZumXR, which is another caffeine source. The product is designed as a stimulant for athletic performance and mental alertness, so if you're sensitive to caffeine or limit your intake for any reason, you should check the label for the exact dose and talk to your doctor or pharmacist first.
What's beta-alanine and why is it in here?
Beta-alanine is an amino acid that research suggests may support athletic performance and physical performance. A common harmless side effect is a tingling or flushing sensation in your skin, usually on the scalp, that starts within 20 minutes and lasts about an hour.
Can I take this while pregnant or breastfeeding?
The safety data isn't clear enough for most of the ingredients in this product during pregnancy and breastfeeding. Caffeine is rated both possibly safe and possibly unsafe — so talk to your doctor about whether it's okay for you and what safe limits might be. For L-tyrosine, beta-alanine, and the toothed clubmoss extract, there isn't enough safety information, so you'd need your doctor's guidance.
What's the toothed clubmoss extract for?
Huperzia serrata extract contains huperzine A, which affects how your brain uses a chemical messenger called acetylcholine. The product may support cognitive function, but we don't have effectiveness data on file for it. It can cause dizziness, nausea, and sweating, and product quality varies, so quality matters here.
Why is there so much sodium in this?
Sodium is an electrolyte that helps with hydration during athletic performance. However, high sodium intake can raise blood pressure and interfere with certain medications, especially blood pressure drugs and lithium. If you take any of those or have high blood pressure, check with your doctor before using this.
Is there anything in this I should avoid if I have a heart condition?
Yes — the caffeine content and the stimulant nature of this product make it risky if you have heart or blood pressure issues. Talk to your doctor or pharmacist before taking it, especially if you're on heart medications or blood pressure drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NOXygen Gummy Bear label
Go deeper

The Full Monographs Behind NOXygen Gummy Bear’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

Read the full Toothed Clubmoss monograph →
Sources

Sources & How We Checked

NOXygen Gummy Bear's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 308 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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Sodium 38 references
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See these in context on the Sodium monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
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See these in context on the Tyrosine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
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See these in context on the Beta-alanine monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
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  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
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  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Toothed Clubmoss 3 references
  1. Budavari S, ed. The Merck Index. 12th ed. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
  2. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
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See these in context on the Toothed Clubmoss monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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