Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

OregaUltra Ingredients & Drug Interactions

by North American Herb & Spice

OregaUltra label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OregaUltra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OregaUltra is a dietary supplement by North American Herb & Spice with 3 active ingredients. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.Based on those ingredients, 912 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against OregaUltra by North American Herb & Spice

Ask about any prescription or over-the-counter medication and we check it for interactions with OregaUltra by North American Herb & Spice — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OregaUltra by North American Herb & Spice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

OregaUltra is a 3-ingredient liquid formula. It contains a proprietary blend (a mixed formula where individual ingredient amounts aren't disclosed), extra virgin olive oil, and black seed oil.

The proprietary blend is the main active component, though the specific herbs or concentrations inside it aren't listed on the label—you'd need to contact the manufacturer for that breakdown.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune and pain support.
  • We looked for evidence on: Stress, Immune function, Inflammation, General wellness.
  • The closest evidence on file: Black Seed is rated "Insufficient Reliable Evidence To Rate" for Stress (Natural Medicines).

Black seed oil in this product is rated possibly effective for acne, hay fever, asthma, Helicobacter pylori infection, and diabetes based on clinical evidence we have on file. Extra virgin olive oil's effectiveness for the conditions we evaluated (osteoporosis, indigestion, exercise-induced respiratory infections, shingles, flu, and osteoarthritis) is rated insufficient reliable evidence—meaning the research so far isn't solid enough to say whether it works.

We don't hold effectiveness data for the proprietary blend component itself.

The evidence, ingredient by ingredient Olive Black Seed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black seed oil is likely unsafe in pregnancy at supplement doses, so you should avoid this product if you're pregnant. The safety data advises against it.

For breastfeeding, there isn't enough reliable safety information available. Black seed is generally well tolerated at typical doses, though gastrointestinal side effects like constipation, stomach discomfort, nausea, and vomiting do occur in some people—in one trial, about one in five participants reported gastrointestinal complaints.

Extra virgin olive oil as a food is very safe, but concentrated supplements are less well studied long-term. One person reported acne after using olive leaf extract in a trial, and olive tree pollen can trigger seasonal respiratory allergies in sensitive individuals.

Side effects, ingredient by ingredient Olive Black Seed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Black Seed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 912 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking OregaUltra, check with your doctor or pharmacist if you use blood pressure medications, blood thinners or antiplatelet drugs, CNS depressants (sedatives, sleep aids, anti-anxiety drugs), antidiabetes drugs, serotonergic antidepressants or migraine medications, immunosuppressants, diuretics, or cyclosporine. All carry moderate-severity interactions with black seed oil in this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is worth discussing with your doctor or pharmacist before you start, especially if you take blood pressure medications, blood thinners, diabetes drugs, sedatives, or antidepressants. The black seed oil here interacts with a broad range of common medications.

If you're pregnant, the safety data advises against it. Your own healthcare provider can help you decide whether this product fits your medications and health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OregaUltra, straight from the product label.

Brand North American Herb & Spice
Barcode (UPC) 635824006961
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 307894
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OregaUltra by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Drop(s)
Maximum serving Sizes:
2 Drop(s)
Servings per container
432
UPC/BARCODE
635824006961
IngredientAmount% DV
Proprietary Blend50 mg--
Extra Virgin Olive Oil0 NP--
Black Seed Oil0 NP--
OregaUltra0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two drops daily. Rub topically to support skin health. Due to heat sensation, keep away from genitals, eyes, and children.

Precautions

Due to heat sensation, keep away from genitals, eyes, and children.

Due to heat sensation, keep away from genitals, eyes, and children.

Beware of cheap imitations from farm-raised, standardized, or adulterated oregano oil.

Formula

OregaUltra is the only truly wild-source, high-carvacrol oregano oil available. The wild oregano in OregaUltra is from extremely high elevations, up to 12,000 feet. 84% carvacrol oregano oil is a powerful cell response formula.

Oil of wild oregano P73 Wild 84% carvacrol

CRC Kosher 748

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Powerful cell response formula Healthy immune & pain support

Non-GMO

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

CRC Kosher 748

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OregaUltra by North American Herb & Spice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OregaUltra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OregaUltra by North American Herb & Spice

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Drop(s) Dosage formLiquid Servings per container432 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

50 mg per serving
Interaction report

OregaUltra by North American Herb & Spice Drug Interactions

Want to check YOUR meds against OregaUltra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
912Drugs
912 Moderate

Ingredients driving the most interactions

Black Seed Oil 912

Individual Drug Interactions

The ingredients in OregaUltra interact with 912 drugs. Click any drug to see the details.

1 of the 3 ingredients in OregaUltra interact with drugs. Each result below shows which ingredient is responsible. Black Seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in OregaUltra with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Seed Oil14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Black Seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OregaUltra, from the product label.

North American Herb & Spice

See all North American Herb & Spice products
Name
NAHS
Street Address
13900 W Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-243-5242
Web Address
www.oreganol.com
Pharmacist Counseling Corner

OregaUltra by North American Herb & Spice: Common Questions

Does OregaUltra by North American Herb & Spice interact with any medications?
Yes. Based on its ingredients, OregaUltra has a known interaction with 912 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OregaUltra contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take OregaUltra if I'm pregnant?
No. Black seed oil, a main ingredient, is rated likely unsafe at supplement doses during pregnancy. If you're thinking about pregnancy or are pregnant, talk with your doctor or pharmacist before using this product.
Is OregaUltra safe while breastfeeding?
There isn't enough reliable safety information on black seed oil during breastfeeding to know either way. Talk with your doctor or pharmacist to decide whether it's right for you.
What are the most common side effects?
Black seed oil can cause gastrointestinal side effects like constipation, stomach discomfort, nausea, and vomiting. In one trial, about one in five people reported some gastrointestinal complaint. Extra virgin olive oil may cause headache or stomach discomfort, and olive tree pollen can trigger seasonal allergies in sensitive people.
Will OregaUltra help with [a specific condition]?
Black seed oil is possibly effective for acne, hay fever, asthma, a stomach infection caused by Helicobacter pylori, and diabetes based on clinical evidence. For other uses, the data we have isn't strong enough to say. Talk with your doctor about whether this product is right for your specific situation.
Why can't I see the exact amounts of ingredients?
The formula contains a proprietary blend, which means the manufacturer doesn't disclose the individual ingredient amounts on the label—it's a mixed formula kept as a trade secret. You can contact North American Herb & Spice directly if you need that breakdown.
Is this product safe long-term?
Black seed oil is likely safe at typical supplement doses short-term but isn't as well studied long-term at higher medicinal amounts. Extra virgin olive oil as a food is very safe, but concentrated supplements are less studied long-term. For long-term use, check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OregaUltra label
Go deeper

The Full Monographs Behind OregaUltra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Black Seed

Interacts with 912 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph →
Sources

Sources & How We Checked

OregaUltra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 62 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Black Seed 60 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
  4. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
  5. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
  6. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
  7. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
  8. Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
  9. Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
  10. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  11. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
  12. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
  13. Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
  14. Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
  15. Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed
  16. El Obeid, A., Al Harbi, S., Al Jomah, N., and Hassib, A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006;13(5):324-333.
  17. Abbas, A. T., Abdel-Aziz, M. M., Zalata, K. R., and Tel, Abd Al-Galel. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Im
  18. Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., and Bano, B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp.Biol. 2006;44(9):745-748.
  19. Hawsawi, Z. A., Ali, B. A., and Bamosa, A. O. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann.Saudi Med 2001;21(3-4):242-244.
  20. Massadeh, A. M., Al Safi, S. A., Momani, I. F., Al Mahmoud, M., and Alkofahi, A. S. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. B PubMed
  21. Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):CR555-CR559.
  22. Meddah, B., Ducroc, R., El Abbes, Faouzi M., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L. C., Cherrah, Y., and Haddad, P. S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. PubMed
  23. Najmi, A., Nasiruddin, M., Khan, R. A., and Haque, S. F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev.Ctries. 2008;28(1):11-14.
  24. al Sheikh, O. A. and Gad el-Rab, M. O. Allergic contact dermatitis: clinical features and profile of sensitizing allergens in Riyadh, Saudi Arabia. Int J Dermatol. 1996;35(7):493-497.
  25. Steinmann, A., Schatzle, M., Agathos, M., and Breit, R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997;36(5):268-269.
  26. Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, et al. Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics. Biomed Res Int 2013;2013:953520.
  27. Arslan E, Sayin S, Demirbas S, et al. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med 2013;11:64-6. PubMed
  28. Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54:344-54.
  29. Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
  30. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
  31. Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One 2015;10:e0113486. PubMed
  32. Mohtashami R, Huseini HF, Heydari M, et al. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol 2015;175:147-52. PubMed
  33. Perveen T, Haider S, Zuberi NA, et al. Increased 5-HT levels following repeated administration of Nigella sativa L. (Black Seed) oil produce antidepressant effects in rats. Sci Pharm 2013;82:161-70. PubMed
  34. Sahebkar A, Soranna D, Liu X, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34:2127-35. PubMed
  35. Shawki M, El Wakeel L, Shatla R, et al. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. Epileptic Disord 2013;15:295-301. PubMed
  36. Muneera KE, Majeed A, Naveed AK. Comparative evaluation of nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. Pak J Pharm Sci. 2015 Mar;28(2):493-8.
  37. Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct. 2015;6(6):2041-8. PubMed
  38. Fallah Huseini H, Amini M, Mohtashami R, et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013;27(12):1849-53.
  39. Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019 Mar;80(3):176-177.
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See these in context on the Black Seed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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