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Dietary supplement

Oregon Leaf Ingredients & Drug Interactions

by Gaia Herbs

Oregon Leaf label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Oregon Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Oregon Leaf is a dietary supplement by Gaia Herbs with 1 active ingredient. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Oregano leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Oregon Leaf by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Oregon Leaf by Gaia Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Oregon Leaf by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Oregon Leaf contains one active ingredient: organic oregano leaf extract. This liquid form also includes organic alcohol and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold doesn't establish that oregano works for acne, bronchitis, asthma, headache, or upper respiratory tract infections — each is rated as having insufficient reliable evidence to rate. If you're considering oregano for one of these reasons, you'd be using it without proven benefit from the data we have.

The evidence, ingredient by ingredient Oregano

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oregano from food amounts is generally well tolerated. The main side effect in trials is mild stomach upset.

Rare serious reactions — including allergic reactions and anaphylaxis — have been reported in people sensitive to oregano or other herbs in its plant family (mint family). Concentrated oregano oil supplements are stronger and less studied than food oregano, so caution is wise.

The safety data advises against medicinal amounts during pregnancy; food amounts are likely fine. For breastfeeding, there isn't enough data to know either way — talk with your doctor or pharmacist about whether to use it.

Side effects, ingredient by ingredient Oregano

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oregano.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this supplement before you start if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — oregano may increase bleeding risk. Also check it with your doctor or pharmacist if you're on diabetes medications, because oregano might lower blood sugar and increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Oregon Leaf is best for people who aren't taking blood thinners, antiplatelet drugs, or diabetes medications. If you use any of those, check with your own doctor or pharmacist first — the interaction risk is real, though it's based partly on lab findings rather than human trials.

If you have a history of allergies to mint-family plants, be cautious. The evidence for its effectiveness in the conditions listed isn't established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oregon Leaf, straight from the product label.

Brand Gaia Herbs
Barcode (UPC) 751063376303
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 212092
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oregon Leaf by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1.33 mL
Servings per container
23
UPC/BARCODE
751063376303
IngredientAmount% DV
organic Oregano leaf extract1.33 mL--

Other ingredients: organic Alcohol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enter ID# at meetyourherbs.com

Facebook Instagram @gaiaherbs

Suggested/Recommended/Usage/Directions

Suggested use Adults take 30-40 drops of extract in a small amount of water 3 times daily between meals. Shake well before use.

Precautions

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed at neck of bottle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

USDA Organic

Formulation

Immune support Traditionally for healthy immune defenses.

Certified Organic by Oregon Tilth.

FDA Statement of Identity

Herbal supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Oregon Leaf by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Oregon Leaf label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Oregon Leaf by Gaia Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Organic Oregano leaf extract

Interacts with
208 drugs
1.33 mL per serving

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...

Organic Oregano leaf extract monograph & interactions

Other (inactive) ingredients: Organic Alcohol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Oregon Leaf by Gaia Herbs Drug Interactions

Want to check YOUR meds against Oregon Leaf?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

organic Oregano leaf extract 208

Individual Drug Interactions

The ingredients in Oregon Leaf interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Oregon Leaf interact with drugs. Each result below shows which ingredient is responsible. organic Oregano leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Oregon Leaf with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Oregano leaf extract2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
organic Oregano leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Oregon Leaf, from the product label.

Gaia Herbs

See all Gaia Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Web Address
www.gaiaherbs.com
Pharmacist Counseling Corner

Oregon Leaf by Gaia Herbs: Common Questions

Does Oregon Leaf by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, Oregon Leaf has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oregon Leaf contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Oregon Leaf help my cough or bronchitis?
The evidence we have doesn't establish that oregano works for bronchitis, asthma, cough, or upper respiratory infections. Each is rated insufficient reliable evidence, so we can't say whether it'll help.
Is oregano safe during pregnancy?
The safety data advises against medicinal or supplement amounts during pregnancy — though food amounts (like seasoning) are likely fine. Talk with your doctor or pharmacist about what's right for your situation.
What are the side effects?
In food amounts, oregano is well tolerated. The most common side effect is mild stomach upset. Rarely, people sensitive to oregano or mint-family plants may have allergic reactions, including anaphylaxis.
Is it safe to breastfeed while taking this?
There isn't enough data to know whether oregano supplements are safe while breastfeeding. Stick to food amounts and talk with your doctor or pharmacist for personalized advice.
Can I take this if I'm on aspirin?
Oregano may increase bleeding risk when combined with aspirin or other blood-thinning drugs. Check with your own doctor or pharmacist before starting — don't skip this step.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Oregon Leaf is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oregon Leaf label
Go deeper

The Full Monographs Behind Oregon Leaf’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph →
Sources

Sources & How We Checked

Oregon Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  5. Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
  6. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  7. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
  8. Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
  9. McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
  10. Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
  11. Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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