Organic Lithium (Orotate) Ingredients & Drug Interactions
by Priority One Nutritional Supplements
What is this page for?
First and foremost: checking Organic Lithium (Orotate) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Lithium (Orotate) is a dietary supplement by Priority One Nutritional Supplements with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Lithium (Orotate) by Priority One Nutritional Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lithium (Orotate) by Priority One Nutritional Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Lithium (Orotate) by Priority One Nutritional Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: lithium, delivered as lithium orotate. The inactive ingredients are rice chelate, carbonate, and a vegetarian capsule.
Lithium is a mineral that's been studied for various uses, though evidence in the data we hold is insufficient to rate it for the conditions listed (alcohol use disorder, Alzheimer disease, ALS, and anorexia nervosa, among others).
Does it work?
Couldn't assess
The evidence we hold on this product is insufficient to rate its effectiveness for any of the conditions studied — these include alcohol use disorder, Alzheimer disease, ALS, anorexia nervosa, and asthma. If you're considering lithium supplementation for a specific reason, talk with your doctor or pharmacist about what the current evidence shows for your situation.
How safe is it?
Well-documented data
Prescription lithium requires blood monitoring because it has a narrow safety margin — the difference between an effective dose and a toxic one is small. Supplement forms aren't as well studied, so it's unclear how lower doses might affect your risk of side effects.
When prescription lithium is used as directed, it's generally well tolerated, though common effects include tremor, fatigue, muscle weakness, weight gain, increased thirst and urination, swelling, and gastrointestinal symptoms. Skin problems like acne and psoriasis can occur or worsen, and rarely, serious reactions like Stevens-Johnson syndrome have been reported.
Lithium is not recommended in pregnancy — it may cross the placenta and has been linked to birth defects. In breastfeeding, lithium passes into milk and may affect the infant.
If you're pregnant, planning pregnancy, or breastfeeding, do not use this product unless your doctor directs and monitors you. If you're taking prescription lithium and thinking of stopping it, taper gradually over at least 14 days — stopping abruptly can trigger a return of bipolar symptoms.
Meds to double-check
Major interaction found
Check with your own doctor or pharmacist before taking this product if you use serotonergic antidepressants (like SSRIs), water pills or diuretics, muscle relaxants, NSAIDs, antipsychotics, ACE inhibitors, calcium channel blockers, or anticonvulsants. These represent the most serious interaction concerns, and some could raise lithium levels dangerously or increase neurological risks.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product carries serious interactions with common medications, especially blood pressure drugs and antidepressants, and lithium itself requires careful monitoring because its safety margin is narrow. The evidence for its effectiveness on the conditions listed is insufficient, and it's not recommended in pregnancy or while breastfeeding.
Before taking it, discuss it with your own doctor or pharmacist — they'll know your complete medication and health picture and can advise whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Lithium (Orotate), straight from the product label.
| Brand | Priority One Nutritional Supplements |
|---|---|
| Barcode (UPC) | 815354020891 |
| Net contents | 250 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2020 |
| DSLD ID | 236794 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Lithium (Orotate) by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lithium | 5 mg | -- |
Other ingredients: Rice Chelate, Carbonate, Vegetarian Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: Do not take if you are pregnant or breast feeding.
Consult your physician before using this product.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Recommendations: Take one (1) capsule three times daily, or as directed by your physician.
Storage
Keep container tightly closed, store in a cool, dry place.
Formulation
Contains no preservatives.
Vegetarian formulation
Non-GMO
General Statements
Bisphenol-A (BPA) & Phthalate Free
Priority One Nutritional Supplements Inc since 1988
For professional use only.
Seals/Symbols
GMP Certified
FDA Statement of Identity
A Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Lithium (Orotate) by Priority One Nutritional Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Lithium (Orotate) by Priority One Nutritional Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
Lithium
Interacts with515 drugs
Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...
Lithium monograph & interactionsOther (inactive) ingredients: Rice Chelate, Carbonate, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.
Organic Lithium (Orotate) by Priority One Nutritional Supplements Drug Interactions
HelloPharmacist Interaction Report
Organic Lithium (Orotate) by Priority One Nutritional Supplements has documented interactions with a large number of medications.
Through its lithium content, this product interacts with serotonergic drugs (like SSRIs), diuretics, muscle relaxants, NSAIDs, antipsychotics, ACE inhibitors, calcium channel blockers, and anticonvulsants. The most serious interactions are with serotonergic drugs and diuretics, both rated Major — serotonergic drugs carry a theoretical risk of serotonin syndrome, while diuretics may increase lithium levels and adverse effects.
Read the full breakdown — every affected drug type, severity by severity
Moderate-severity interactions affect skeletal muscle relaxants (risk of prolonged neuromuscular blockade), NSAIDs (may increase lithium levels), antipsychotics (risk of encephalopathic syndrome with weakness, confusion, and fever), ACE inhibitors (may raise lithium levels), calcium channel blockers (may alter lithium levels and neurological effects), and anticonvulsants (risk of nerve damage). Altogether, these interactions span 515 individual medications.
Lithium has a narrow safety window, and supplement doses aren't well studied the way prescription forms are — it's unclear whether the smaller amounts in this product would cause clinically significant problems. Before you start, check your exact medications with the search tool on this page and confirm with your own doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Lithium (Orotate)?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Lithium (Orotate) interact with 515 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Lithium (Orotate) interact with drugs. Each result below shows which ingredient is responsible. Lithium
Amitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs, Phenothiazines +1 Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline, Perphenazine interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Ammonium Chloride interactionAmoxapineAsendin
How Amoxapine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs, Antipsychotic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumAntipsychotic Drugs, Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Read the full Lithium + Aripiprazole Lauroxil interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumNonsteroidal Anti-inflammatory Drugs (nsaids), Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
Read the full Lithium + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Atenolol, Chlorthalidone interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl SalicylateUrinary Antiseptic 2, Urised
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Meperidine interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Azilsartan, Chlorthalidone interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumAce Inhibitors (aceis), Diuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Read the full Lithium + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Benzhydrocodone, Acetaminophen interactionBenzocaine, DextromethorphanTetra-Formula
How Benzocaine, Dextromethorphan interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Benzocaine, Dextromethorphan interactionBenzthiazideExna
How Benzthiazide interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Benzthiazide interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bisoprolol, Hydrochlorothiazide interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumAntipsychotic Drugs, Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Read the full Lithium + Brexpiprazole interactionBrompheniramine, Dextromethorphan, PhenylephrineDimetapp DM
How Brompheniramine, Dextromethorphan, Phenylephrine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Brompheniramine, Dextromethorphan, Phenylephrine interactionBumetanideBurinex
How Bumetanide interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bumetanide, Potassium interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Buprenorphine interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Organic Lithium (Orotate) — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Buproprion, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Lithium (Orotate) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lithium
Diuretic Drugs
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Serotonergic Drugs
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Ace Inhibitors (Aceis)
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Anticonvulsants
Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Antipsychotic Drugs
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Calcium Channel Blockers
Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Methyldopa (Aldomet)
Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Methylxanthines
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Phenothiazines
Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Skeletal Muscle Relaxants
Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Brand information
Manufacturer and brand details for Organic Lithium (Orotate), from the product label.
Priority One Nutritional Supplements
See all Priority One Nutritional Supplements products- Name
- Priority One Nutritional Supplements, Inc.
Organic Lithium (Orotate) by Priority One Nutritional Supplements: Common Questions
Does Organic Lithium (Orotate) by Priority One Nutritional Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is lithium orotate safe to take if I'm pregnant or breastfeeding?
What are the most common side effects of lithium supplements?
Do I need to have my blood levels checked if I take this lithium supplement?
Can I stop taking lithium supplements whenever I want?
Does this product really work for depression or bipolar disorder?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Lithium (Orotate) is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Lithium (Orotate)’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Organic Lithium (Orotate)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lithium 26 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
- Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9.. PubMed
- Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131. PubMed
- Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079. PubMed
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
- Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92. DOI
- Rauf A, Gul S, Nasir M, Arif U, Oyenuga M. A Rare Case of Lithium-induced Partial Nephrogenic Diabetes Insipidus. Cureus. 2020;12(4):e7877. PubMed
- Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118. PubMed
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