Interactions on record — worth a quick check against your medications. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

P6 Extreme Ingredients & Drug Interactions

by Cellucor

P6 Extreme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking P6 Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

P6 Extreme is a dietary supplement by Cellucor with 9 active ingredients. Its ingredients are commonly taken for hot flashes and night sweats, other menopause symptoms, mood changes during menopause.Based on those ingredients, 872 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Cohosh root extract, Tribulus alatus extract, Stinging Nettle root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against P6 Extreme by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with P6 Extreme by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of P6 Extreme by Cellucor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “P6 Extreme Blend” is a proprietary blend — the label gives one combined amount (947 mg) without saying how much of each component you get.

P6 Extreme is a 9-ingredient capsule. Its active ingredients are black cohosh root extract, beta-sitosterol, myricetin, stinging nettle root extract, ovine placenta powder, agaricus bisporus extract, wild yam root extract, sclareolide, and tribulus alatus extract.

The product also contains inactive ingredients: capsule shell, microcrystalline cellulose, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Natural testosterone booster for athletic performance.
  • We looked for evidence on: Athletic performance, Male infertility, Erectile dysfunction (ED), Sexual dysfunction, Exercise-induced muscle damage, Muscle strength — and 2 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Male infertility, Exercise-induced muscle damage.

Black cohosh is possibly effective for menopausal symptoms, but evidence is insufficient to rate it for acne, sexual dysfunction, anxiety, or breast cancer-related hot flashes. Beta-sitosterol is likely effective for benign prostatic hyperplasia (enlarged prostate) and possibly effective for familial hypercholesterolemia and coronary heart disease.

Stinging nettle is possibly effective for diabetes but has insufficient evidence for allergic rhinitis, anemia, asthma, benign prostatic hyperplasia, or gingivitis. Tribulus is possibly effective for sexual dysfunction but appears possibly ineffective for athletic performance, with insufficient evidence for benign prostatic hyperplasia.

Wild yam appears possibly ineffective for menopausal symptoms, with insufficient evidence for gallbladder disease, sexual dysfunction, dysmenorrhea, or infertility. We hold no effectiveness data for myricetin, ovine placenta powder, agaricus bisporus extract, or sclareolide.

The evidence, ingredient by ingredient Black Cohosh Beta-sitosterol Stinging Nettle Agaricus Mushroom Wild Yam Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black cohosh is generally well tolerated short-term at typical doses, but liver concerns are rare and medical guidance is wise. Common side effects include breast tenderness, dizziness, gastrointestinal upset, headache, irritability, rash, and tiredness.

Rare serious effects include endometrial hyperplasia and liver damage. Beta-sitosterol is generally well tolerated and commonly causes constipation, diarrhea, gas, indigestion, or nausea; it can worsen acne and rarely has been associated with pancreatitis.

Stinging nettle is generally well tolerated and may cause constipation or diarrhea; one case of liver disease has been reported. Wild yam is generally well tolerated short-term, with common effects including fever, headache, upset stomach, and vomiting; anaphylaxis is rare.

Tribulus is often well tolerated short-term, though rare serious effects include liver and kidney injury, seizures, and painful erection; gastrointestinal complaints are possible. For pregnancy and breastfeeding: black cohosh, stinging nettle, wild yam, and tribulus all lack sufficient safety data and should be avoided during pregnancy and breastfeeding — talk to your doctor before use if you are pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Black Cohosh Beta-sitosterol Stinging Nettle Agaricus Mushroom Wild Yam Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Tribulus, Stinging Nettle, Black Cohosh, Wild Yam, Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 873 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking P6 Extreme, check with your pharmacist if you take serotonergic drugs like antidepressants or duloxetine (risk of serotonin syndrome — Major severity). Also double-check if you use antidiabetes drugs, antihypertensive drugs, warfarin, lithium, hepatotoxic drugs, atorvastatin, cisplatin, estrogen therapy, or any drug metabolized by CYP2D6 — all Moderate severity.

We could not check myricetin, ovine placenta powder, agaricus bisporus extract, or sclareolide against medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

P6 Extreme is a multi-ingredient product marketed for sexual function and related concerns. If you take any blood sugar medication, blood pressure medication, warfarin, lithium, antidepressants, estrogen therapy, or any CYP2D6 substrate drug (ask your pharmacist), you need to check your exact medications before starting this product.

Pregnant women, those planning pregnancy, and breastfeeding women should avoid it. Talk to your pharmacist or doctor — especially if you have liver concerns or are on any regular medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about P6 Extreme, straight from the product label.

Brand Cellucor
Barcode (UPC) 632964301703
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3682
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for P6 Extreme by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
632964301703
IngredientAmount% DV
Black Cohosh root extract0 NP--
Beta-Sitosterol0 NP--
Myricetin0 NP--
Stinging Nettle root extract0 NP--
P6 Extreme Blend947 mg--
Ovine Placenta powder0 NP--
Agaricus bisporus extract0 NP--
Wild Yam root extract0 NP--
Sclareolide0 NP--
Tribulus alatus extract250 mg--

Other ingredients: Capsule Shell, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement for adults, use for up to 8 weeks in a cycle then discontinue use for 4 weeks before beginning a new cycle. In the morning: Take 2 capsules with or without food. In the evening before bed: Take 2 capsules with or without food. Athlete Disclosure: Due to the unique restrictions of amateur and professional sports organizations (WADA, NCAA, NFL, MLB, NBA, UIL, etc.) It is recommended that you consult with the appropriate governing body before taking this or any other dietary supplement.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose treat, cure or prevent any disease.

Formula

May Contain Soy

General Statements

30 DAY SUPPLY

ADVANCED ANABOLIC STACK

Chrome Series 3RD GENERATION

GMP CERTIFIED

NATURAL TESTOSTERONE BOOSTER*

PLEASE RECYCLE

STRENGTH* LEAN MUSCLE* LIBIDO* STAMINA*

General

v3.2

Precautions

WARNING: Contains black cohosh which is not to be used while pregnant or nursing.

NOTE: Do not exceed recommended daily intake. Use only as directed.

This product is not intended for use by those with a serious medical condition. Consult a physician before use. Do not use if you have hormone sensitive cancer, diabetes, kidney disease, renal disorders, allergies to Asteraceae/Compositae family, or if you are using any other dietary supplement, prescription drug including but not limited to anticoagulants, anti-diabetes drugs, antihypertensive drugs, CNS depressants, oral contraceptive hormone therapy drugs. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Exceeding recommended dosage may cause serious adverse health effects, including but not limited to acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

P6 Extreme by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

P6 Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in P6 Extreme by Cellucor

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

P6 Extreme Blend

947 mg per serving

Tribulus alatus extract

Interacts with
259 drugs
250 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus alatus extract monograph & interactions

Other (inactive) ingredients: Capsule Shell, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

P6 Extreme by Cellucor Drug Interactions

Want to check YOUR meds against P6 Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
872Drugs
858 Moderate 14 Minor

Ingredients driving the most interactions

Black Cohosh root extract 652
Tribulus alatus extract 259
Stinging Nettle root extract 164
Agaricus bisporus extract 86
Wild Yam root extract 41

Individual Drug Interactions

The ingredients in P6 Extreme interact with 872 drugs. Click any drug to see the details.

5 of the 9 ingredients in P6 Extreme interact with drugs. Each result below shows which ingredient is responsible. Black Cohosh root extract Tribulus alatus extract Stinging Nettle root extract Agaricus bisporus extract Wild Yam root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in P6 Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Cohosh root extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh root extract full monograph & interactions

Tribulus alatus extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus alatus extract full monograph & interactions

Stinging Nettle root extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle root extract full monograph & interactions

Agaricus bisporus extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus bisporus extract full monograph & interactions

Wild Yam root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for P6 Extreme, from the product label.

Cellucor

See all Cellucor products
Name
Woodbolt(TM) INTERNATIONAL
Street Address
715 N. Main Street
City
Bryan
State
TX
ZipCode
77803
Web Address
www.cellucor.com
Pharmacist Counseling Corner

P6 Extreme by Cellucor: Common Questions

Does P6 Extreme by Cellucor interact with any medications?
Yes. Based on its ingredients, P6 Extreme has a known interaction with 872 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
P6 Extreme contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take P6 Extreme if I'm pregnant or breastfeeding?
No. Black cohosh, stinging nettle, wild yam, and tribulus in this product all lack enough safety data during pregnancy and breastfeeding. Avoid it and talk to your doctor before taking any new supplement if you're pregnant, planning pregnancy, or nursing.
What is black cohosh used for in this product?
Black cohosh root extract is possibly effective for menopausal symptoms. It may help with hot flashes and related discomfort, though evidence for other uses like sexual dysfunction and anxiety is insufficient.
Does beta-sitosterol really help with prostate health?
Yes — beta-sitosterol is likely effective for benign prostatic hyperplasia (enlarged prostate). It's also possibly effective for high cholesterol and heart disease, though it's one of several ingredients in this product.
What side effects might I experience?
Black cohosh commonly causes breast tenderness, dizziness, headache, or gastrointestinal upset. Beta-sitosterol often causes constipation, diarrhea, or indigestion. Stinging nettle and wild yam may cause constipation or diarrhea. Most side effects are mild, but rare serious liver effects have been reported with black cohosh and stinging nettle.
Why does this product have so many interactions with medications?
P6 Extreme contains multiple botanical ingredients — black cohosh, stinging nettle, tribulus, and wild yam — each of which can interact with different drug types. Black cohosh alone affects drugs processed by your liver, blood sugar medications, blood thinners, and antidepressants. That's why checking your exact medications is important.
Is it safe to take P6 Extreme long-term?
Black cohosh is generally well tolerated short-term, but long-term safety isn't well studied and there are rare liver concerns — medical guidance is wise. Beta-sitosterol is generally well tolerated, but long-term data for the other ingredients are limited. Talk to your pharmacist about how long to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

P6 Extreme label
Go deeper

The Full Monographs Behind P6 Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph → Herb & supplement monograph

Beta-sitosterol

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...

Read the full Beta-sitosterol monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

P6 Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Cohosh 68 references
  1. McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16. PubMed
  2. Whiting PW, Clouston A, Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2002;177:440-3. PubMed
  3. Pepping J. Black cohosh: Cimicifuga racemosa. Am J Health Syst Pharm 1999;56:1400-2. PubMed
  4. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther 1998;15:45-53.
  5. Kruse SO, Lohning A, Pauli GF, et al. Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid. Planta Med 1999;65:763-4.
  6. Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001;19:2739-45. PubMed
  7. Gunn TR, Wright IM. The use of black and blue cohosh in labour. N Z Med J 1996;109:410-1.
  8. Baillie N, Rasmussen P. Black and blue cohosh in labour. N Z Med J 1997;110:20-1.
  9. Lontos S, Jones RM, Angus PW, Gow PJ. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2003;179:390-1.. DOI
  10. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003;44:S67-77. PubMed
  11. Huntley A, Ernst E. A systematic review of the safety of black cohosh. Menopause 2003;10:58-64.. DOI
  12. Cohen SM, O'Connor AM, Hart J, et al. Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause 2004;11:575-7. PubMed
  13. Vitetta L, Thomsen M, Sali A. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2003;178:411-2.. PubMed
  14. Thomsen M, Vitetta L, Schmidt M, Sali A. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2004;180:598-600.. DOI
  15. Cohen B, Schardt D. Center for Science in the Public Interest. Letter to Food and Drug Administration. Commissioner Mark McClellan, MD, PhD. March 4, 2004.
  16. Seidlova-Wuttke D, Hesse O, Jarry H, et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol 2003;149:351-62. PubMed
  17. Rockwell S, Liu Y, Higgins SA. Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh. Breast Cancer Res Treat 2005;90:233-9. PubMed
  18. Levitsky J, Alli TA, Wisecarver J, Sorrell MF. Fulminant liver failure associated with the use of black cohosh. Dig Dis Sci 2005;50:538-9. PubMed
  19. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  20. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005;20:30-5.
  21. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
  22. Minciullo PL, Saija A, Patafi M, et al. Muscle damage induced by black cohosh (Cimicifuga racemosa). Phytomedicine 2006;13:115-8. PubMed
  23. Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Men PubMed
  24. MHRA. Black cohosh (Cimicifuga racemosa) - risk of liver problems. Herbal Safety News July 2006. Available at: http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary= true&ssDocName=CON2024131&ssTargetNodeId=663.
  25. Dugoua JJ, Seely D, Perri D, et al. Safety and efficacy of black cohosh (cimicifuga racemosa) during pregnancy and lactation. Can J Clin Pharmacol 2006;13:e257-61.
  26. Raus K, Brucker C, Gorkow C, Wuttke W. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause 2006;13:678-91. PubMed
  27. Lynch CR, Folkers ME, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl 2006;12:989-92. PubMed
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