No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Pan 5X Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Pan 5X is a dietary supplement by Progressive Professional from Progressive Laboratories with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Pan 5X by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.

Pan 5X contains 4 active ingredients, all digestive enzymes designed to help break down food. Protease breaks down proteins, lipase handles fats, amylase tackles carbohydrates, and pancreatin is a combination enzyme blend from the pancreas.

The capsule also contains rice flour, gelatin, and vegetable lubricant as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Pancreatic insufficiency, Fat malabsorption, Indigestion.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence on these enzymes is limited. For protease and lipase, we have insufficient reliable evidence to rate their effectiveness for inflammatory bowel disease (a chronic gut condition), indigestion, or premature infants.

The product facts don't provide effectiveness ratings for amylase or pancreatin, so we can't speak to how well they work.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated by most adults, though some people report digestive upset or allergic reactions. Protease can rarely trigger allergic responses similar to those seen with occupational enzyme exposure.

For pregnancy, protease safety hasn't been established and is best avoided unless prescribed; lipase has little safety data in pregnancy, so use only if your doctor advises it. During breastfeeding, both enzymes have limited safety data — check with your healthcare provider before using.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, we hold no interaction data for amylase and pancreatin.

If you take any medications, it's still smart to run them through the interaction checker on this page, or ask your pharmacist.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

Pan 5X is a digestive enzyme blend that may help with food breakdown, though solid evidence for specific conditions is thin. If you have serious digestive problems, use it only under medical guidance.

Most adults tolerate it well, but pregnant or breastfeeding women should talk with their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pan 5X, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821009643
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 323751
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pan 5X by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
351821009643
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Pancreatin175 mg--

Other ingredients: Rice Flour, Gelatin, Vegetable Lubricant

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule with each meal, or more, as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health care professional.

Pregnant and/or lactating women should consult their physician prior to use.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of reach of children.

Formula

The porcine glandular material in this product is prepared by a special process which does not exceed physiological temperature (37 degrees C).

Raw Pancreas Enzyme concentrate

Formulation

Guaranteed to be free of chemical pesticides and synthetic hormones. This product is made without sugar, salt, wheat, corn, yeast or soy derivatives.

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Seals/Symbols

Certified GMP Complaint GMP Good Manufacturing Practices 21 CFR 111

FDA Statement of Identity

Dietary Supplement

See for yourself

Pan 5X by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pan 5X by Progressive Professional from Progressive Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Pancreatin

175 mg per serving Form: Porcine

Other (inactive) ingredients: Rice Flour, Gelatin, Vegetable Lubricant. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pan 5X by Progressive Professional from Progressive Laboratories Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Pan 5X. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Pan 5X, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Pan 5X by Progressive Professional from Progressive Laboratories: Common Questions

Does Pan 5X by Progressive Professional from Progressive Laboratories interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Pan 5X. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Pan 5X contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does each enzyme in Pan 5X do?
Amylase breaks down carbohydrates, protease breaks down proteins, and lipase breaks down fats. Pancreatin is a blend of all three from the pancreas. Together they're meant to help your body digest food more completely.
Is Pan 5X safe during pregnancy?
Protease is best avoided in pregnancy unless your doctor prescribes it. Lipase has limited safety data in pregnancy, so use it only if your doctor advises it. We don't have safety information on file for amylase and pancreatin during pregnancy — talk with your doctor for personalized advice.
Can I take Pan 5X while breastfeeding?
There isn't enough safety data on protease or lipase during breastfeeding to recommend them without medical advice. Check with your healthcare provider before using. We have no safety data on file for amylase and pancreatin while breastfeeding.
What side effects might Pan 5X cause?
Most people tolerate the enzymes well. Digestive upset is possible with protease or lipase. Rarely, protease can cause allergic reactions, including respiratory symptoms in people sensitive to occupational enzyme exposure.
Does Pan 5X really work for indigestion and inflammatory bowel disease?
We have insufficient reliable evidence to rate these enzymes for either indigestion or inflammatory bowel disease, so we can't say whether they work for those conditions. Talk with your doctor about whether they're right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pan 5X is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pan 5X label
Sources

Sources & How We Checked

Pan 5X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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