No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Pancreas 8xtra Ingredients & Drug Interactions

by Priority One Nutritional Supplements

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Pancreas 8xtra is a dietary supplement by Priority One Nutritional Supplements with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Pancreas 8xtra by Priority One Nutritional Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (1,600 mg) without saying how much of each component you get.

Pancreas 8xtra contains 3 active ingredients: amylase, protease, and lipase. These are digestive enzymes that break down carbohydrates, proteins, and fats in food, respectively.

The product also contains inactive ingredients — silicon dioxide, gelatin, and purified water — which serve as flow agents and the capsule shell.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Pancreatic enzyme support and digestion.
  • We looked for evidence on: Dyspepsia, Pancreatic insufficiency, Fat malabsorption, Enzyme deficiency.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence we hold for these enzymes is limited. Lipase has been studied for inflammatory bowel disease and dyspepsia (indigestion), but the data is insufficient to rate how well it works for either condition.

Amylase and protease effectiveness ratings are not on file in our data. If you're considering this for a specific digestive condition, talk with your pharmacist or doctor about what the research actually supports for your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated in supplement form for most adults. Some people report digestive upset or, rarely, allergic reactions.

Protease can occasionally trigger allergic reactions in people sensitive to occupational or environmental enzyme exposure; lipase has not been thoroughly evaluated for safety. For pregnancy: safety data is limited for both protease and lipase — use only if your doctor advises it.

For breastfeeding: there is little safety data for either ingredient, so check with your healthcare provider first. We hold no pregnancy or breastfeeding data for amylase.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented for the ingredients we could check. We cannot verify amylase for interactions.

If you take any medications — especially those that affect blood clotting, blood sugar, or digestion — check them with the tool below before adding this product.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This product may help if you're looking for digestive enzyme support, but the evidence for specific conditions is thin. If you're pregnant, breastfeeding, or have a serious digestive condition, talk with your pharmacist or doctor before starting.

Run your medications through the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pancreas 8xtra, straight from the product label.

Brand Priority One Nutritional Supplements
Barcode (UPC) 815354021072
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 310771
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pancreas 8xtra by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
815354021072
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Pancreatin1600 mg--

Other ingredients: Silicon Dioxide, Gelatin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Recommendations: Take two (2) capsules before meals or as directed by your physician.

Storage

Keep container tightly closed, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Contains no preservatives. Bisphenol-A (BPA) & Phthalate free

Supports healthy digestion.

Non-GMO

For professional use only.

Seals/Symbols

GMP Certified

Brand IP Statement(s)

Priority One Nutritional Supplements Inc. Since 1998

FDA Statement of Identity

A Dietary Supplement

See for yourself

Pancreas 8xtra by Priority One Nutritional Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pancreas 8xtra by Priority One Nutritional Supplements

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pancreatin

1600 mg per serving

Other (inactive) ingredients: Silicon Dioxide, Gelatin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pancreas 8xtra by Priority One Nutritional Supplements Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Pancreas 8xtra. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Pancreas 8xtra, from the product label.

Priority One Nutritional Supplements

See all Priority One Nutritional Supplements products
Name
Priority One Nutritional Supplements, Inc.
Web Address
www.priorityonevitamins.com
Pharmacist Counseling Corner

Pancreas 8xtra by Priority One Nutritional Supplements: Common Questions

Does Pancreas 8xtra by Priority One Nutritional Supplements interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Pancreas 8xtra. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Pancreas 8xtra contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do these enzymes actually do?
Amylase breaks down carbohydrates, protease breaks down proteins, and lipase breaks down fats. Together they help your digestive system work through a meal.
Can I take this while pregnant?
Safety data is limited for both protease and lipase in pregnancy. Only use it if your doctor says it's okay. We don't have pregnancy data for amylase.
What if I'm breastfeeding?
There's very little safety data for protease or lipase while breastfeeding. Check with your healthcare provider first before using this product.
Are there any side effects I should know about?
Most people tolerate these enzymes well, but some experience digestive upset. Rarely, allergic reactions can occur, especially in people sensitive to enzyme dust from occupational or environmental exposure.
Does this work for IBS or other digestive conditions?
The evidence for lipase in indigestion and inflammatory bowel disease is insufficient to say how well it works. If you have a serious digestive condition, talk with your doctor before trying this.
What are the inactive ingredients?
The capsule contains silicon dioxide, gelatin, and purified water. These are fillers and binders that help form the capsule — they're not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pancreas 8xtra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pancreas 8xtra label
Sources

Sources & How We Checked

Pancreas 8xtra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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