Pancreatin 10X Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking Pancreatin 10X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pancreatin 10X is a dietary supplement by SuperSmart with 3 active ingredients. Its ingredients are commonly taken for swelling and inflammation after injury or surgery, wound healing, cataract surgery (intracapsular).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Pancreatin 10X by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Pancreatin 10X contains three active ingredients: chymotrypsin, trypsin, and porcine pancreatin. These are digestive enzymes—proteins that break down food into smaller pieces your body can absorb.
Chymotrypsin and trypsin are proteases (enzymes that split proteins), and porcine pancreatin is a blend of pancreatic enzymes from pigs. All three are derived from animal sources.
The product also contains inactive ingredients—hypromellose, acacia gum, and white rice flour—which are fillers and binders that help form the capsule.
Does it work?
Strong evidence
Chymotrypsin is rated effective for cataracts. For burns, fractures, and chronic obstructive parotitis, the evidence isn't strong enough to rate it reliably.
Trypsin has been studied for sprains, osteoarthritis, radiation dermatitis, wound healing, exercise-induced muscle soreness, and multiple sclerosis, but in each case the evidence is insufficient to rate it. The data we hold doesn't establish that either enzyme works well for most conditions they're used for.
How safe is it?
Well-documented data
Both chymotrypsin and trypsin are generally tolerated for short-term use, but quality evidence is limited and some people may react to these animal-derived enzymes. Rare but serious reactions to chymotrypsin include anaphylaxis—sudden breathing trouble, hives, swelling, shock, and collapse that can be life-threatening.
Trypsin taken by mouth with other enzymes can cause mild-to-moderate stomach upset: nausea, heartburn, and stomach pain. When applied to skin, trypsin may cause localized pain and brief burning.
Chymotrypsin injected into the eye has caused increased eye pressure, swelling of the cornea, and inflammation inside the eye, though oral use (as in this product) carries different risks. During pregnancy, the safety data advises against chymotrypsin and trypsin.
Breastfeeding safety is not established for either ingredient. Data on porcine pancreatin during pregnancy and breastfeeding is not on file.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we don't hold interaction data for porcine pancreatin.
Because digestive enzymes can influence how some drugs are absorbed, ask your pharmacist to review your full medication list before you start, especially if you take blood thinners or other narrow-margin drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
This product is a digestive enzyme blend from animal sources. If you're looking for help with cataracts, chymotrypsin has a solid evidence base.
For other uses—sprains, arthritis, wound healing—the evidence is thin. Anyone with a known enzyme allergy or a history of allergic reactions should be cautious.
If you're pregnant, breastfeeding, or taking medications, talk with your pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pancreatin 10X, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003827016 |
| Net contents | 120 Gastro-Resistant Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 332720 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pancreatin 10X by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chymotrypsin | 4 mg | -- |
| Trypsin | 10 mg | -- |
| Porcine Pancreatin | 400 mg | -- |
Other ingredients: Hypromellose, Acacia Gum, White Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Formulation
Guarantees: Non-GMO, gluten free, soy free, dairy free. No coloring, preservatives, or flavorings.
FDA Registered Lab, Good Manufacturing Practice, Made in USA.
Suggested/Recommended/Usage/Directions
Directions: Adults. As a supplement, take 2 capsules two times daily or as directed by the practitioner.
Storage
Cautions: Better kept refrigerated. Store in a cool, dry place.
Precautions
Keep out of reach of children.
Consult a healthcare provider before using this product if pregnant, breastfeeding, or having health concerns.
Tamper evident: Do not use if seal under cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pancreatin 10X by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pancreatin 10X by SuperSmart
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Chymotrypsin
No knowninteractions
Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelli...
Chymotrypsin monograph & interactionsTrypsin
No knowninteractions
Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chym...
Trypsin monograph & interactionsPorcine Pancreatin
Other (inactive) ingredients: Hypromellose, Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.
Pancreatin 10X by SuperSmart Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Pancreatin 10X. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Pancreatin 10X, from the product label.
SuperSmart
See all SuperSmart products- Name
- SuperSmart USA LLC
- City
- Miami
- State
- FL
- ZipCode
- 33130
- Phone Number
- +1 (786) 522-3907
- Web Address
- us.SuperSmart.com
Pancreatin 10X by SuperSmart: Common Questions
Does Pancreatin 10X by SuperSmart interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What exactly is porcine pancreatin?
Is this safe to take if I'm pregnant or breastfeeding?
What are the side effects I should watch for?
Does this actually work for what I want to use it for?
Why can't you check interactions for porcine pancreatin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pancreatin 10X is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pancreatin 10X’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Chymotrypsin
Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelling and support healing after injury or s...
Read the full Chymotrypsin monograph → Herb & supplement monographTrypsin
Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chymotrypsin and bromelain) for swelling and...
Read the full Trypsin monograph →Sources & How We Checked
Pancreatin 10X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 23 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chymotrypsin 6 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.
- Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
- Shaw PC. The use of a trypsin-chymotrypsin formulation in fractures of the hand. Br J Clin Pract 1969;23:25-6. DOI
- McCue FC, Webster TM, Gieck J. Clinical effects of proteolytic enzymes after reconstructive hand surgery. Int Surg 1972;57:479-82.
- Sun HJ, Xiao JQ, Qiao QH, et al. Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. Int J Oral Maxillofac Surg 2017;46(7):877-82. doi: 10.1016/j.ijom.2017.02.1267. PubMed
Trypsin 17 references
- Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
- Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. PubMed
- Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
- Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp
- Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. PubMed
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. PubMed
- Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. PubMed
- US Department of Justice. U.S. Files Complaint Against Texas-Based Healthpoint Ltd. Under the False Claims Act. https://www.justice.gov/opa/pr/us-files-complaint-against-texas-based-healthpoint-ltd-under-false-claims-act. (Accessed June 19, 2019).
- Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. PubMed
- Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. PubMed
- Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47 Suppl:S23-8. PubMed
- Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. PubMed
- Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. PubMed
- Popiela T, Kulig J, Klek S, Wachol D, Bock PR, Hanisch J. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek. 2000;57 Suppl 5:142.
- Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac S PubMed
- Comparison of Chronic Wound Care Products. Pharmacist's Letter/Prescriber's Letter 2008;12(3):1203.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC