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Dietary supplement

Bioflavonoids 500 mg Ingredients & Drug Interactions

by Nature's Life

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bioflavonoids 500 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bioflavonoids 500 mg by Nature's Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This tablet contains 3 active ingredients: hesperidin complex, rutin complex, and lemon bioflavonoid complex. Hesperidin and rutin are naturally occurring plant compounds (bioflavonoids) that may support various aspects of health, while lemon bioflavonoid adds another source of these plant compounds.

The product also contains several inactive ingredients — cellulose, rose hips, acerola juice powder, green pepper, stearic acid, and silica — which serve as fillers, binders, and flow agents to hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: capillary health and vitamin C absorption.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins, Postoperative swelling, Lymphedema, Fragile capillaries — and 3 related terms.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Lymphedema, Varicose veins, Postoperative swelling.
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI), Hemorrhoids, Lymphedema.

The evidence for hesperidin and rutin is limited. For hesperidin, the data we hold shows it's possibly ineffective for obesity and high cholesterol, and there isn't enough reliable evidence to rate it for fatty liver disease.

Rutin shows insufficient evidence for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-related respiratory infections, and hemorrhoids — meaning the evidence simply isn't established enough to say whether it works for these uses. Lemon bioflavonoid likewise has insufficient evidence for hay fever, anxiety, respiratory infections, high blood pressure, and kidney stones.

If you're considering this product for a specific health concern, talk with your doctor or pharmacist about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Hesperidin Rutin Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin and rutin are generally well tolerated in food amounts and short-term use, but long-term safety data at supplement doses is limited. Adverse effects are uncommon: hesperidin has one reported case of allergic skin rash in a person who applied it topically, while rutin may cause headache, flushing, or rash in some people.

Lemon bioflavonoid is well tolerated in food amounts; larger medicinal doses may cause heartburn and stomach discomfort — one trial found gastrointestinal upset in 37% of people taking lemon juice at higher doses, compared to 8% on placebo. For pregnancy, hesperidin and rutin have conflicting or limited data — one rating says likely safe, another says possibly safe or insufficient information, so talk with your doctor before taking this during pregnancy.

For breastfeeding, hesperidin and lemon have insufficient safety data at supplement doses, and rutin safety while breastfeeding is unknown — your doctor or pharmacist can help you decide whether it's right for you.

Side effects, ingredient by ingredient Hesperidin Rutin Lemon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Rutin, Lemon, Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 783 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use blood thinners or antiplatelet drugs (moderate risk of increased bleeding), blood pressure medications, sedatives or sleep aids, verapamil, diltiazem, celiprolol, diabetes medications, or the antifungal itraconazole. All of these have documented interactions with one or more ingredients in this product.

Your doctor or pharmacist can tell you whether it's safe to take together or if timing matters.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This bioflavonoid blend is generally well tolerated at supplement doses in the short term, though long-term safety data is sparse. If you take blood thinners, blood pressure medications, heart drugs like verapamil or diltiazem, diabetes medications, or the antifungal itraconazole, you'll need to check with your doctor or pharmacist before starting it — the interactions are documented in animal or lab research, not yet in people, but they're worth confirming.

If you're pregnant or breastfeeding, talk with your healthcare provider first. Use the medication checker on this page to see if any of your drugs are on the interaction list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bioflavonoids 500 mg, straight from the product label.

Brand Nature's Life
Barcode (UPC) 040647001510
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60616
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bioflavonoids 500 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
040647001510
IngredientAmount% DV
Hesperidin Complex75 mg--
Rutin Complex75 mg--
Lemon Bioflavonoid Complex500 mg--

Other ingredients: Cellulose, Rose Hips, Acerola juice powder, Green Pepper, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Sun Food Energy

This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.

Formula

Lemon Bioflavonoids Hesperidin & Rutin

Suggested/Recommended/Usage/Directions

1 Daily

Directions: Take one (1) tablet up to two times daily with food.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING

General Statements

Discussion: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C.

Quality You Can Trust.

@MMVI

Formulation

Nature's Life guarantees that NO ingredients other than those listed on this label have been added to this product.

Suitable For Vegetarians

General

102378 1206

See for yourself

Bioflavonoids 500 mg by Nature's Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bioflavonoids 500 mg by Nature's Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hesperidin Complex

Interacts with
702 drugs
75 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Complex monograph & interactions

Rutin Complex

Interacts with
86 drugs
75 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin Complex monograph & interactions

Lemon Bioflavonoid Complex

Interacts with
1 drug
500 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Lemon Bioflavonoid Complex monograph & interactions

Other (inactive) ingredients: Cellulose, Rose Hips, Acerola juice powder, Green Pepper, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bioflavonoids 500 mg by Nature's Life Drug Interactions

Want to check YOUR meds against Bioflavonoids 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
783Drugs
783 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Bioflavonoids 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin Complex7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D

Rutin Complex1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D

Lemon Bioflavonoid Complex1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Bioflavonoids 500 mg, from the product label.

Nature's Life

See all Nature's Life products
Phone Number
800-247-6997
Web Address
WWW.NATURESLIFE.COM
Pharmacist Counseling Corner

Bioflavonoids 500 mg by Nature's Life: Common Questions

Does Bioflavonoids 500 mg by Nature's Life interact with any medications?
Yes. Based on its ingredients, Bioflavonoids 500 mg has a known interaction with 783 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bioflavonoids 500 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Hesperidin in this product may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs, based on animal studies. This effect hasn't been seen in people yet, but it's important enough to check with your doctor or pharmacist before starting — they can help you decide if it's safe for you or if you need to space it out differently from your medication.
What are bioflavonoids and why are they in this product?
Bioflavonoids are plant compounds found naturally in fruits, vegetables, and herbs. Hesperidin comes from citrus, rutin from buckwheat and other plants, and lemon bioflavonoid from lemon. They're included because some research suggests they may support health, though for most uses the evidence we hold is limited or not yet established.
Will this lower my blood sugar if I take diabetes medication?
Rutin, one of the three ingredients, may theoretically lower blood sugar based on animal studies. If you take diabetes medication, there's a theoretical risk of low blood sugar (hypoglycemia) — talk with your doctor or pharmacist before taking this product to see if it's safe to combine.
What are the most common side effects?
Rutin may cause headache, flushing, or rash in some people. Lemon bioflavonoid may cause heartburn or stomach discomfort, especially at higher doses — one trial found that about 37% of people taking larger amounts of lemon juice experienced some stomach upset. Hesperidin is well tolerated but rarely may trigger allergic skin reactions in sensitive individuals.
Is it safe to take this while I'm pregnant?
The safety data for hesperidin and rutin during pregnancy is limited and contradictory — one says possibly safe, another says insufficient information. Lemon bioflavonoid data is also incomplete. Because the evidence isn't clear, it's best to talk with your doctor or pharmacist before taking this product during pregnancy to get personalized advice.
Can I take this if I'm breastfeeding?
Safety data for hesperidin and lemon bioflavonoid while breastfeeding is not well established, and rutin safety is unknown. The facts advise against it or recommend caution — talk with your doctor or pharmacist to decide whether it's right for you, since they know your full health picture.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bioflavonoids 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bioflavonoids 500 mg label
Sources

Sources & How We Checked

Bioflavonoids 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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