Bioflavonoids 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bioflavonoids 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bioflavonoids 500 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bioflavonoids 500 mg by Nature's Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Bioflavonoids 500 mg by Nature's Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bioflavonoids 500 mg by Nature's Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This tablet contains 3 active ingredients: hesperidin complex, rutin complex, and lemon bioflavonoid complex. Hesperidin and rutin are naturally occurring plant compounds (bioflavonoids) that may support various aspects of health, while lemon bioflavonoid adds another source of these plant compounds.
The product also contains several inactive ingredients — cellulose, rose hips, acerola juice powder, green pepper, stearic acid, and silica — which serve as fillers, binders, and flow agents to hold the tablet together.
Does it work?
Not established
The evidence for hesperidin and rutin is limited. For hesperidin, the data we hold shows it's possibly ineffective for obesity and high cholesterol, and there isn't enough reliable evidence to rate it for fatty liver disease.
Rutin shows insufficient evidence for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-related respiratory infections, and hemorrhoids — meaning the evidence simply isn't established enough to say whether it works for these uses. Lemon bioflavonoid likewise has insufficient evidence for hay fever, anxiety, respiratory infections, high blood pressure, and kidney stones.
If you're considering this product for a specific health concern, talk with your doctor or pharmacist about whether the evidence supports its use for your situation.
How safe is it?
Well-documented data
Hesperidin and rutin are generally well tolerated in food amounts and short-term use, but long-term safety data at supplement doses is limited. Adverse effects are uncommon: hesperidin has one reported case of allergic skin rash in a person who applied it topically, while rutin may cause headache, flushing, or rash in some people.
Lemon bioflavonoid is well tolerated in food amounts; larger medicinal doses may cause heartburn and stomach discomfort — one trial found gastrointestinal upset in 37% of people taking lemon juice at higher doses, compared to 8% on placebo. For pregnancy, hesperidin and rutin have conflicting or limited data — one rating says likely safe, another says possibly safe or insufficient information, so talk with your doctor before taking this during pregnancy.
For breastfeeding, hesperidin and lemon have insufficient safety data at supplement doses, and rutin safety while breastfeeding is unknown — your doctor or pharmacist can help you decide whether it's right for you.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you use blood thinners or antiplatelet drugs (moderate risk of increased bleeding), blood pressure medications, sedatives or sleep aids, verapamil, diltiazem, celiprolol, diabetes medications, or the antifungal itraconazole. All of these have documented interactions with one or more ingredients in this product.
Your doctor or pharmacist can tell you whether it's safe to take together or if timing matters.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This bioflavonoid blend is generally well tolerated at supplement doses in the short term, though long-term safety data is sparse. If you take blood thinners, blood pressure medications, heart drugs like verapamil or diltiazem, diabetes medications, or the antifungal itraconazole, you'll need to check with your doctor or pharmacist before starting it — the interactions are documented in animal or lab research, not yet in people, but they're worth confirming.
If you're pregnant or breastfeeding, talk with your healthcare provider first. Use the medication checker on this page to see if any of your drugs are on the interaction list.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bioflavonoids 500 mg, straight from the product label.
| Brand | Nature's Life |
|---|---|
| Barcode (UPC) | 040647001510 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2016 |
| DSLD ID | 60616 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bioflavonoids 500 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hesperidin Complex | 75 mg | -- |
| Rutin Complex | 75 mg | -- |
| Lemon Bioflavonoid Complex | 500 mg | -- |
Other ingredients: Cellulose, Rose Hips, Acerola juice powder, Green Pepper, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Sun Food Energy
This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.
Formula
Lemon Bioflavonoids Hesperidin & Rutin
Suggested/Recommended/Usage/Directions
1 Daily
Directions: Take one (1) tablet up to two times daily with food.
FDA Statement of Identity
Dietary Supplement
Storage
Store in a cool, dry place.
Precautions
Keep out of reach of children.
DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING
General Statements
Discussion: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C.
Quality You Can Trust.
@MMVI
Formulation
Nature's Life guarantees that NO ingredients other than those listed on this label have been added to this product.
Suitable For Vegetarians
General
102378 1206
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bioflavonoids 500 mg by Nature's Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bioflavonoids 500 mg by Nature's Life
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hesperidin Complex
Interacts with702 drugs
Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...
Hesperidin Complex monograph & interactionsRutin Complex
Interacts with86 drugs
Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...
Rutin Complex monograph & interactionsLemon Bioflavonoid Complex
Interacts with1 drug
Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...
Lemon Bioflavonoid Complex monograph & interactionsOther (inactive) ingredients: Cellulose, Rose Hips, Acerola juice powder, Green Pepper, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
Bioflavonoids 500 mg by Nature's Life Drug Interactions
HelloPharmacist Interaction Report
Bioflavonoids 500 mg by Nature's Life contains three active ingredients, and hesperidin (the main one) has documented moderate interactions with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs — hesperidin may theoretically increase bleeding risk based on animal data showing antiplatelet activity, though this hasn't been reported in people.
Read the full breakdown — every affected drug type, severity by severity
Hesperidin also interacts moderately with blood pressure medications (antihypertensives), sedatives and sleep aids (CNS depressants), and two specific heart medications: verapamil and diltiazem, where it may raise their levels in your blood. It can also affect how your body processes certain medications through P-glycoprotein, a protein that normally clears drugs out of your cells.
Additionally, hesperidin may lower the effectiveness of celiprolol, a beta-blocker used for heart rhythm and blood pressure.
Rutin, the second ingredient, has a moderate interaction with diabetes medications — animal studies suggest it can lower blood sugar, which could increase the risk of low blood sugar (hypoglycemia) if combined with antidiabetes drugs. Lemon bioflavonoid complex has a minor interaction with itraconazole, an antifungal medication, where lemon may raise its levels.
Altogether, these interactions span 783 individual medications. Before you start this product, check your exact medications with the tool on this page, then talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bioflavonoids 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bioflavonoids 500 mg interact with 783 drugs. Click any drug to see the details.
3 of the 3 ingredients in Bioflavonoids 500 mg interact with drugs. Each result below shows which ingredient is responsible. Hesperidin Complex Rutin Complex Lemon Bioflavonoid Complex
AbciximabReoPro
How Abciximab interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
Read the full Hesperidin Complex + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Rutin ComplexAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin Complex + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Read the full Hesperidin Complex + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Meperidine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bioflavonoids 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Hesperidin Complex
Anticoagulant/Antiplatelet Drugs
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.
Antihypertensive Drugs
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.
Celiprolol (Celicard)
Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.
Cns Depressants
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.
Diltiazem (Cardizem, Others)
Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.
P-Glycoprotein Substrates
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.
Verapamil (Calan, Others)
Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans
Rutin Complex
Antidiabetes Drugs
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.
Lemon Bioflavonoid Complex
Itraconazole (Sporanox)
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.
Brand information
Manufacturer and brand details for Bioflavonoids 500 mg, from the product label.
Nature's Life
See all Nature's Life products- Phone Number
- 800-247-6997
- Web Address
- WWW.NATURESLIFE.COM
Bioflavonoids 500 mg by Nature's Life: Common Questions
Does Bioflavonoids 500 mg by Nature's Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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What are bioflavonoids and why are they in this product?
Will this lower my blood sugar if I take diabetes medication?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bioflavonoids 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bioflavonoids 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hesperidin
Interacts with 702 drugsHesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...
Read the full Hesperidin monograph → Herb & supplement monographRutin
Interacts with 86 drugsRutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...
Read the full Rutin monograph → Herb & supplement monographLemon
Interacts with 1 drugLemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...
Read the full Lemon monograph →Sources & How We Checked
Bioflavonoids 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hesperidin 14 references
- Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
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Rutin 2 references
- Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
- Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.
Lemon 2 references
- Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
- Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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