Bioflavonoids 1,000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bioflavonoids 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bioflavonoids 1,000 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bioflavonoids 1,000 mg by Nature's Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Bioflavonoids 1,000 mg by Nature's Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Bioflavonoids 1,000 mg by Nature's Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains three active bioflavonoid ingredients. Hesperidin Complex and Rutin Complex are plant-derived compounds studied for their potential effects on blood sugar, cholesterol, and circulation.
Lemon Bioflavonoid Complex is derived from lemon and adds another set of bioflavonoids to the mix. The product also includes several inactive ingredients—cellulose, stearic acid, silica, green pepper, rose hips, and acerola cherry—which serve as fillers, binders, and flow agents in the tablet.
Does it work?
Not established
The evidence supporting these ingredients is limited. Hesperidin Complex rates as possibly ineffective for obesity and high cholesterol, and there's insufficient evidence to know whether it helps with fatty liver disease.
Rutin Complex has insufficient evidence for most of its studied uses, including diabetes, inflammatory bowel disease, hemorrhoids, and exercise-related respiratory infections. Lemon Bioflavonoid Complex similarly shows insufficient evidence for allergies, anxiety, high blood pressure, respiratory infections, and kidney stones.
In short, we don't have solid data showing these ingredients work for their commonly marketed purposes.
How safe is it?
Well-documented data
All three ingredients are generally well tolerated when used as food or in short-term supplements, though high-quality long-term safety data are limited for each. Hesperidin and Rutin can occasionally cause side effects—a case of allergic skin reaction was reported with topical hesperidin, and Rutin may cause headache, flushing, or rashes in some people.
Lemon taken in large amounts can cause heartburn and stomach upset; in one trial, 37% of people consuming fresh lemon juice reported gastrointestinal disturbance compared to 8% on placebo. For pregnancy, the safety data is mixed and incomplete.
Hesperidin carries two conflicting ratings (Likely Safe and Possibly Safe), and the product's safety notes advise against it in pregnancy due to insufficient information. Rutin is rated Likely Safe in pregnancy but the notes say to avoid supplement doses unless your doctor advises otherwise.
Lemon has no pregnancy rating on file. For breastfeeding, Hesperidin and Rutin safety data advise against use unless your doctor approves.
Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you start, double-check with your doctor or pharmacist if you take any blood pressure medications (Moderate risk), blood thinners or antiplatelet drugs like warfarin (Moderate risk), diabetes medications (Moderate risk), heart medications such as verapamil or diltiazem (Moderate risk), any sedating drugs or opioids (Moderate risk), or itraconazole for fungal infections (Minor risk). No interactions are documented for the ingredients we could not check, but that doesn't mean none exist—your own healthcare provider is the best resource to confirm your specific medications are safe to combine with this product.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This bioflavonoid product is best suited for someone interested in general antioxidant support who isn't on blood pressure, heart, diabetes, anticoagulant, or sedating medications—and who's discussed it with their own doctor or pharmacist first. If you take any prescription medications, especially for blood pressure, heart rhythm, bleeding, diabetes, or sleep, check your specific drugs against the interaction tool on this page before starting.
The evidence for what these ingredients actually do is thin, so set realistic expectations. Talk it over with your doctor or pharmacist to make sure it fits your health picture.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bioflavonoids 1,000 mg, straight from the product label.
| Brand | Nature's Life |
|---|---|
| Barcode (UPC) | 040647001541 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2017 |
| DSLD ID | 81937 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bioflavonoids 1,000 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hesperidin Complex | 100 mg | -- |
| Rutin Complex | 100 mg | -- |
| Lemon Bioflavonoid Complex | 1000 mg | -- |
Other ingredients: Cellulose, Stearic Acid, Silica, Green Pepper, Rose Hips, Acerola Cherry
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Sun Food Energy
This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.
Formula
Lemon bioflavonoids Hesperidin & rutin
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
1 daily
Directions: Take one (1) tablet up to two times daily with food.
Storage
Store in a cool, dry place.
Precautions
Keep out of the reach of children.
Do not use if safety seal is broken or missing
General Statements
Discussion: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C. Nature's Life guarantees that no ingredients other than those listed on this label have been added to his product.
Quality you can trust.
Formulation
Suitable for vegetarians
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bioflavonoids 1,000 mg by Nature's Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bioflavonoids 1,000 mg by Nature's Life
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hesperidin Complex
Interacts with702 drugs
Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...
Hesperidin Complex monograph & interactionsRutin Complex
Interacts with86 drugs
Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...
Rutin Complex monograph & interactionsLemon Bioflavonoid Complex
Interacts with1 drug
Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...
Lemon Bioflavonoid Complex monograph & interactionsOther (inactive) ingredients: Cellulose, Stearic Acid, Silica, Green Pepper, Rose Hips, Acerola Cherry. These complete the product’s ingredient list but are not active constituents.
Bioflavonoids 1,000 mg by Nature's Life Drug Interactions
HelloPharmacist Interaction Report
Bioflavonoids 1,000 mg by Nature's Life contains three active ingredients—Hesperidin Complex, Rutin Complex, and Lemon Bioflavonoid Complex—that together carry documented interactions with medications.
The most serious concern is Hesperidin Complex, which theoretically can increase sedation when combined with CNS depressants (sedating drugs, opioids, alcohol) due to its own sedative effects shown in animal research, though this hasn't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Hesperidin Complex also raises Moderate concerns with blood pressure-lowering drugs (antihypertensive drugs), blood thinners and antiplatelet medications, and several heart medications. It may lower your blood pressure further if you're already on blood pressure medication, increase bleeding risk if you take warfarin or similar drugs, or boost the levels of verapamil, diltiazem, or certain other heart drugs—potentially causing stronger effects than intended.
It can also theoretically interfere with a broad category of drugs called P-glycoprotein substrates, which includes many common medications.
Rutin Complex carries a Moderate interaction with diabetes medications—it may theoretically increase the risk of low blood sugar (hypoglycemia) based on animal evidence. Lemon Bioflavonoid Complex has one documented Minor interaction: it may raise itraconazole levels if you take that antifungal medication as a capsule or tablet.
Altogether, these interactions span 783 individual medications. Run your exact prescriptions through the interaction checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bioflavonoids 1,000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bioflavonoids 1,000 mg interact with 783 drugs. Click any drug to see the details.
3 of the 3 ingredients in Bioflavonoids 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Hesperidin Complex Rutin Complex Lemon Bioflavonoid Complex
AbciximabReoPro
How Abciximab interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
Read the full Hesperidin Complex + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Rutin ComplexAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin Complex + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Read the full Hesperidin Complex + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Bioflavonoids 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Meperidine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bioflavonoids 1,000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Hesperidin Complex
Anticoagulant/Antiplatelet Drugs
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.
Antihypertensive Drugs
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.
Celiprolol (Celicard)
Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.
Cns Depressants
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.
Diltiazem (Cardizem, Others)
Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.
P-Glycoprotein Substrates
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.
Verapamil (Calan, Others)
Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans
Rutin Complex
Antidiabetes Drugs
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.
Lemon Bioflavonoid Complex
Itraconazole (Sporanox)
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.
Brand information
Manufacturer and brand details for Bioflavonoids 1,000 mg, from the product label.
Nature's Life
See all Nature's Life products- Phone Number
- 800-247-6997
- Web Address
- WWW.NATURESLIFE.COM
Bioflavonoids 1,000 mg by Nature's Life: Common Questions
Does Bioflavonoids 1,000 mg by Nature's Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take this while I'm pregnant?
Can I take this if I'm breastfeeding?
What are the side effects I should watch for?
Does this actually work for high cholesterol or weight loss?
Why do the inactive ingredients include rose hips and acerola cherry?
Is there anything special about taking this with food?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bioflavonoids 1,000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bioflavonoids 1,000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hesperidin
Interacts with 702 drugsHesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...
Read the full Hesperidin monograph → Herb & supplement monographRutin
Interacts with 86 drugsRutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...
Read the full Rutin monograph → Herb & supplement monographLemon
Interacts with 1 drugLemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...
Read the full Lemon monograph →Sources & How We Checked
Bioflavonoids 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hesperidin 14 references
- Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
- Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
- Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
- Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
- El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
- Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
- Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
- Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
- Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
- Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
- Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
- Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
- Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
- Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed
Rutin 2 references
- Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
- Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.
Lemon 2 references
- Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
- Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC