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Dietary supplement

Bioflavonoids 1,000 mg Ingredients & Drug Interactions

by Nature's Life

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bioflavonoids 1,000 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bioflavonoids 1,000 mg by Nature's Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains three active bioflavonoid ingredients. Hesperidin Complex and Rutin Complex are plant-derived compounds studied for their potential effects on blood sugar, cholesterol, and circulation.

Lemon Bioflavonoid Complex is derived from lemon and adds another set of bioflavonoids to the mix. The product also includes several inactive ingredients—cellulose, stearic acid, silica, green pepper, rose hips, and acerola cherry—which serve as fillers, binders, and flow agents in the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: nutritive support for healthy capillaries and vitamin C absorption.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins, Postoperative swelling, Capillary fragility, Easy bruising — and 1 related terms.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Varicose veins, Postoperative swelling.
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins.

The evidence supporting these ingredients is limited. Hesperidin Complex rates as possibly ineffective for obesity and high cholesterol, and there's insufficient evidence to know whether it helps with fatty liver disease.

Rutin Complex has insufficient evidence for most of its studied uses, including diabetes, inflammatory bowel disease, hemorrhoids, and exercise-related respiratory infections. Lemon Bioflavonoid Complex similarly shows insufficient evidence for allergies, anxiety, high blood pressure, respiratory infections, and kidney stones.

In short, we don't have solid data showing these ingredients work for their commonly marketed purposes.

The evidence, ingredient by ingredient Hesperidin Rutin Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three ingredients are generally well tolerated when used as food or in short-term supplements, though high-quality long-term safety data are limited for each. Hesperidin and Rutin can occasionally cause side effects—a case of allergic skin reaction was reported with topical hesperidin, and Rutin may cause headache, flushing, or rashes in some people.

Lemon taken in large amounts can cause heartburn and stomach upset; in one trial, 37% of people consuming fresh lemon juice reported gastrointestinal disturbance compared to 8% on placebo. For pregnancy, the safety data is mixed and incomplete.

Hesperidin carries two conflicting ratings (Likely Safe and Possibly Safe), and the product's safety notes advise against it in pregnancy due to insufficient information. Rutin is rated Likely Safe in pregnancy but the notes say to avoid supplement doses unless your doctor advises otherwise.

Lemon has no pregnancy rating on file. For breastfeeding, Hesperidin and Rutin safety data advise against use unless your doctor approves.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Hesperidin Rutin Lemon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Rutin, Lemon, Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 783 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take any blood pressure medications (Moderate risk), blood thinners or antiplatelet drugs like warfarin (Moderate risk), diabetes medications (Moderate risk), heart medications such as verapamil or diltiazem (Moderate risk), any sedating drugs or opioids (Moderate risk), or itraconazole for fungal infections (Minor risk). No interactions are documented for the ingredients we could not check, but that doesn't mean none exist—your own healthcare provider is the best resource to confirm your specific medications are safe to combine with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This bioflavonoid product is best suited for someone interested in general antioxidant support who isn't on blood pressure, heart, diabetes, anticoagulant, or sedating medications—and who's discussed it with their own doctor or pharmacist first. If you take any prescription medications, especially for blood pressure, heart rhythm, bleeding, diabetes, or sleep, check your specific drugs against the interaction tool on this page before starting.

The evidence for what these ingredients actually do is thin, so set realistic expectations. Talk it over with your doctor or pharmacist to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bioflavonoids 1,000 mg, straight from the product label.

Brand Nature's Life
Barcode (UPC) 040647001541
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Dec 22, 2017
DSLD ID 81937
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bioflavonoids 1,000 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
040647001541
IngredientAmount% DV
Hesperidin Complex100 mg--
Rutin Complex100 mg--
Lemon Bioflavonoid Complex1000 mg--

Other ingredients: Cellulose, Stearic Acid, Silica, Green Pepper, Rose Hips, Acerola Cherry

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Sun Food Energy

This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.

Formula

Lemon bioflavonoids Hesperidin & rutin

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 daily

Directions: Take one (1) tablet up to two times daily with food.

Storage

Store in a cool, dry place.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing

General Statements

Discussion: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C. Nature's Life guarantees that no ingredients other than those listed on this label have been added to his product.

Quality you can trust.

Formulation

Suitable for vegetarians

See for yourself

Bioflavonoids 1,000 mg by Nature's Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bioflavonoids 1,000 mg by Nature's Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hesperidin Complex

Interacts with
702 drugs
100 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Complex monograph & interactions

Rutin Complex

Interacts with
86 drugs
100 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin Complex monograph & interactions

Lemon Bioflavonoid Complex

Interacts with
1 drug
1000 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Lemon Bioflavonoid Complex monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Silica, Green Pepper, Rose Hips, Acerola Cherry. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bioflavonoids 1,000 mg by Nature's Life Drug Interactions

Want to check YOUR meds against Bioflavonoids 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
783Drugs
783 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Bioflavonoids 1,000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin Complex7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D

Rutin Complex1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D

Lemon Bioflavonoid Complex1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Bioflavonoids 1,000 mg, from the product label.

Nature's Life

See all Nature's Life products
Phone Number
800-247-6997
Web Address
WWW.NATURESLIFE.COM
Pharmacist Counseling Corner

Bioflavonoids 1,000 mg by Nature's Life: Common Questions

Does Bioflavonoids 1,000 mg by Nature's Life interact with any medications?
Yes. Based on its ingredients, Bioflavonoids 1,000 mg has a known interaction with 783 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bioflavonoids 1,000 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while I'm pregnant?
The data on file is mixed and incomplete. There isn't enough information to say it's definitely safe, so supplements should be avoided during pregnancy unless your doctor specifically advises otherwise. Talk with your doctor or pharmacist about your individual situation.
Can I take this if I'm breastfeeding?
Safety information is not enough to recommend it. The data advise against supplement doses while breastfeeding. Check with your doctor or pharmacist before using it.
What are the side effects I should watch for?
These ingredients are generally well tolerated, but some people report headache, flushing, or rashes from Rutin. Hesperidin rarely triggered an allergic skin reaction in one reported case. Taking it in large amounts—especially the lemon component—can cause heartburn and stomach upset. Stop and contact your doctor if you notice any unusual reactions.
Does this actually work for high cholesterol or weight loss?
The evidence doesn't support it. Hesperidin Complex rates as possibly ineffective for both cholesterol and obesity. There's no solid proof these ingredients will help with those goals.
Why do the inactive ingredients include rose hips and acerola cherry?
They're used as fillers and binders to form and stabilize the tablet. They're not active therapeutic ingredients in this product.
Is there anything special about taking this with food?
The facts on file don't specify timing or food interactions. Your pharmacist can advise you on the best way to take it with your meals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bioflavonoids 1,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bioflavonoids 1,000 mg label
Sources

Sources & How We Checked

Bioflavonoids 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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