PancreMax Ingredients & Drug Interactions
by Karuna
What is this page for?
First and foremost: checking PancreMax against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PancreMax is a dietary supplement by Karuna with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PancreMax by Karuna
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
PancreMax has 5 active ingredients — all digestive enzymes. Protease breaks down protein, lipase handles fat, and amylase works on carbohydrates.
You're also getting pancreatin concentrate and a second lipase concentrate, both derived from dried pancreatic tissue, to give you a fuller range of enzyme activity. Gelatin is the inactive ingredient that makes up the capsule itself.
Does it work?
Not established
The evidence on lipase and protease for conditions like inflammatory bowel disease (IBD) and indigestion (dyspepsia) is insufficient — we don't have reliable data yet on how well they work for those uses. If you're considering this for a specific digestive condition, talk with your pharmacist or doctor about what the science actually supports.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated for most adults, though some people report mild digestive upset or allergic reactions. If you have a serious digestive condition, use only under medical guidance.
For pregnancy: there isn't enough safety data for either ingredient — check with your doctor first. During breastfeeding, the data is also limited — ask your healthcare provider before using.
One rare note: recombinant lipase in premature infants has been linked to serious gut complications, but this product isn't formulated for that population.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we were able to check in PancreMax. Still, check your exact medications with the search tool below before you begin.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
PancreMax is a blend of digestive enzymes that's generally well tolerated in adults. If you have a chronic gut condition or you're pregnant or breastfeeding, run it by your doctor or pharmacist first.
No medication interactions are documented for the ingredients we checked, but verify your specific drugs on this page before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PancreMax, straight from the product label.
| Brand | Karuna |
|---|---|
| Barcode (UPC) | 018647031073 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2025 |
| DSLD ID | 327122 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PancreMax by Karuna, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Pancreatin Concentrate, Pan Dried, Pure | 500 mg | -- |
| Lipase Concentrate, Pan Dried | 31 mg | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Higher potency pancreatic enzymes
Brand IP Statement(s)
Karuna Responsible Nutrition
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use for adults: 1-2 capsules per meal, or as directed by your health care practitioner.
Precautions
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
Formulation
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.
Storage
Keep in a cool, dry place, tightly capped.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PancreMax by Karuna label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PancreMax by Karuna
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsPancreatin Concentrate, Pan Dried, Pure
Lipase Concentrate, Pan Dried
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase Concentrate, Pan Dried monograph & interactionsOther (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
PancreMax by Karuna Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PancreMax. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PancreMax, from the product label.
Karuna
See all Karuna products- Name
- Karuna Corporation
- Street Address
- 42 Digital Drive #7
- City
- Novato
- State
- CA
- ZipCode
- 94949
- Phone Number
- 800-826-7225
PancreMax by Karuna: Common Questions
Does PancreMax by Karuna interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is PancreMax safe to take if I'm pregnant?
Can I use this while breastfeeding?
What does protease do?
Are there any side effects I should know about?
Does this product actually work for IBS or indigestion?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PancreMax is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PancreMax’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
PancreMax's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC