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Dietary supplement

Papaya Enzyme Chewable Ingredients & Drug Interactions

by Ron Teeguarden Nutraceuticals

Papaya Enzyme Chewable label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Enzyme Chewable against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Enzyme Chewable is a dietary supplement by Ron Teeguarden Nutraceuticals with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: protease, alpha amylase, and papain. Protease and alpha amylase are enzymes that help break down proteins and starches respectively during digestion.

Papain is an enzyme extracted from papaya that's added for similar digestive support. The tablet also contains inactive ingredients including fructose, calcium carbonate, papaya flavor, stearin, corn starch, and magnesium stearate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive support and enzyme supplementation.
  • We looked for evidence on: Exercise-induced muscle soreness, Wound healing, Inflammation, Bloating, Post-surgical recovery.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence for papain in treating the conditions this product might be used for — cancer, dental cavities, radiation skin damage, exercise soreness, shingles, and intestinal parasites — is rated as insufficient. That means the data we have doesn't establish whether it works for any of these.

Protease and alpha amylase are not rated in our data for effectiveness.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food, but the supplement form may irritate your digestive tract or trigger allergic reactions in sensitive people. Protease is generally well tolerated in most adults, though it can occasionally cause digestive upset or allergic reactions.

Occupational exposure to airborne protease or papain dust has caused respiratory symptoms like sneezing, cough, and wheezing in some people, though this is rare with oral supplements. High oral doses of papain may be unsafe and have caused severe stomach inflammation and, in rare cases, esophageal perforation.

For pregnancy, concentrated papain and unripe papaya products are not recommended due to safety concerns. During breastfeeding, there isn't enough reliable safety data for papain, so medical advice is needed before use.

Protease also has not had safety established in pregnancy, so it should be avoided unless prescribed, and there is little safety data during breastfeeding without medical advice.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Warfarin (Coumadin) and other blood thinners (anticoagulants) — papain may increase their effect and raise bleeding risk. If you take any blood thinner or anticoagulant, confirm with your doctor or pharmacist before using this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is digestive enzyme support that uses papain, protease, and alpha amylase. If you take warfarin or any blood thinner, you need to check with your doctor or pharmacist before starting this — the papain may increase blood-thinning effects.

If you're pregnant or breastfeeding, talk it over with your healthcare provider first, as safety data is limited. For anyone else considering it, run your complete medication list through the interaction tool on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Enzyme Chewable, straight from the product label.

Brand Ron Teeguarden Nutraceuticals
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 316702
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
IngredientAmount% DV
Protease2 mg--
Alpha Amylase2 mg--
Papain15 mg--

Other ingredients: Fructose, Calcium Carbonate, Papaya flavor, Stearin, Corn Starch, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no salt, dairy, yeast, wheat, gluten, soy, preservatives or artificial colors.

Vegetarian formula

Quality & potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults chew one (1) tablet with meals, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Enzyme Chewable label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
2 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Alpha Amylase

2 mg per serving

Papain

Interacts with
2 drugs
15 mg per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Fructose, Calcium Carbonate, Papaya flavor, Stearin, Corn Starch, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals Drug Interactions

Want to check YOUR meds against Papaya Enzyme Chewable?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Papaya Enzyme Chewable interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in Papaya Enzyme Chewable interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Enzyme Chewable with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Enzyme Chewable, from the product label.

Ron Teeguarden Nutraceuticals

See all Ron Teeguarden Nutraceuticals products
Name
Ron Teeguarden's Nutraceuticals
Pharmacist Counseling Corner

Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals: Common Questions

Does Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals interact with any medications?
Yes. Based on its ingredients, Papaya Enzyme Chewable has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Enzyme Chewable contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without checking first. Papain in this product may increase warfarin's blood-thinning effect, which could raise your bleeding risk. A case report documented one person whose blood thickness went dangerously high after taking a papaya supplement. Talk to your doctor or pharmacist before adding this.
Is papain safe during pregnancy?
No. Concentrated papain and unripe papaya products are not recommended in pregnancy due to safety concerns. If you're pregnant or planning to be, ask your doctor before using any product with papain.
What are the most common side effects?
Allergic reactions in sensitive people — itchy watery eyes, runny nose, sneezing, abdominal cramps, or diarrhea. Protease may cause digestive upset. Serious side effects like severe stomach inflammation or esophageal perforation are rare but can happen at high doses.
Does this product have fillers?
Yes. Beyond the three active enzymes, it contains fructose, calcium carbonate, papaya flavor, stearin, corn starch, and magnesium stearate as inactive ingredients.
Can I use this while breastfeeding?
There isn't enough reliable safety data for papain or protease during breastfeeding. It's best to avoid supplemental papain and protease without medical advice. Talk to your doctor or pharmacist about whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Enzyme Chewable label
Go deeper

The Full Monographs Behind Papaya Enzyme Chewable’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papaya Enzyme Chewable's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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