Papaya Enzyme Chewable Ingredients & Drug Interactions
by Ron Teeguarden Nutraceuticals
What is this page for?
First and foremost: checking Papaya Enzyme Chewable against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Papaya Enzyme Chewable is a dietary supplement by Ron Teeguarden Nutraceuticals with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals
Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Papaya Enzyme Chewable has 3 active ingredients: protease, alpha amylase, and papain. These are digestive enzymes — proteases break down proteins, amylase breaks down starches, and papain is derived from papaya fruit and also breaks down protein.
Together they're meant to help with protein digestion.
Does it work?
Not established
The evidence we have for papain doesn't establish that it works for the purposes it's sometimes marketed for — cancer, dental cavities, radiation skin damage, muscle soreness after exercise, shingles, or intestinal parasites all show insufficient reliable evidence. The supplement facts don't include effectiveness ratings for the protease or amylase ingredients.
How safe is it?
Well-documented data
Protease and papain are generally well tolerated when used short-term at normal doses, though both can trigger allergic reactions in sensitive people — itching, watery eyes, sneezing, stomach cramps, or diarrhea. High doses of papain may be unsafe and could cause severe stomach inflammation or, rarely, esophageal perforation.
Occupational exposure to airborne enzyme dust can cause respiratory allergies including wheezing and asthma, though that's less of a concern with a chewable tablet. During pregnancy, concentrated papain and unripe papaya products are best avoided due to safety concerns.
For protease, safety data during pregnancy is too limited — it's best avoided unless your doctor prescribes it. While breastfeeding, neither protease nor papain has enough safety data; use isn't recommended without medical advice.
Meds to double-check
Moderate interaction found
Blood thinners like warfarin (Coumadin) — papain may boost their effects and raise your bleeding risk. Before you take this product, use the medication checker below to search your exact prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This chewable is an enzyme blend for digestive support. If you take warfarin or any blood thinner, check with your pharmacist before starting.
If you have a known allergy to papaya or enzymes, skip this one. Otherwise, talk to your pharmacist if you're pregnant, breastfeeding, or on any regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Papaya Enzyme Chewable, straight from the product label.
| Brand | Ron Teeguarden Nutraceuticals |
|---|---|
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 316702 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Protease | 2 mg | -- |
| Alpha Amylase | 2 mg | -- |
| Papain | 15 mg | -- |
Other ingredients: Fructose, Calcium Carbonate, Papaya flavor, Stearin, Corn Starch, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contains no salt, dairy, yeast, wheat, gluten, soy, preservatives or artificial colors.
Vegetarian formula
Quality & potency guaranteed
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, adults chew one (1) tablet with meals, or as directed by a health care professional.
Storage
Store in a cool, dry place and away from direct light.
Precautions
Keep out of reach of children.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsAlpha Amylase
Papain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsOther (inactive) ingredients: Fructose, Calcium Carbonate, Papaya flavor, Stearin, Corn Starch, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals Drug Interactions
HelloPharmacist Interaction Report
Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals contains papain, which has documented interactions with blood thinners.
The main concern is warfarin (Coumadin) — papain may increase its effects and side effects, raising your bleeding risk. In one case report, a patient stable on warfarin developed dangerously high INR levels after taking a papain-containing supplement.
Read the full breakdown — every affected drug type, severity by severity
Protease, another ingredient here, was checked and has no known interactions documented in our data. Alpha Amylase could not be checked — we hold no interaction data for it.
Although we've identified interactions with these medications, that's not a complete safety guarantee. Run your exact medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Papaya Enzyme Chewable?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Papaya Enzyme Chewable interact with 2 drugs. Click any drug to see the details.
1 of the 3 ingredients in Papaya Enzyme Chewable interact with drugs. Each result below shows which ingredient is responsible. Papain
WarfarinWarfarin
How Warfarin interacts with Papaya Enzyme Chewable — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Papaya Enzyme Chewable — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Papaya Enzyme Chewable with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Papaya Enzyme Chewable, from the product label.
Ron Teeguarden Nutraceuticals
See all Ron Teeguarden Nutraceuticals products- Name
- Ron Teeguarden's Nutraceuticals
Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals: Common Questions
Does Papaya Enzyme Chewable by Ron Teeguarden Nutraceuticals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What are the digestive enzymes supposed to do?
Can I have an allergic reaction to this?
Does papain really help with wound healing or muscle soreness?
Are there fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Papaya Enzyme Chewable is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Papaya Enzyme Chewable’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographPapain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph →Sources & How We Checked
Papaya Enzyme Chewable's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC