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Dietary supplement

Papaya Supreme Ingredients & Drug Interactions

by Swanson Premium Brand

Papaya Supreme label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Supreme is a dietary supplement by Swanson Premium Brand with 1 active ingredient. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papaya Supreme by Swanson Premium Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Supreme by Swanson Premium Brand — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Supreme by Swanson Premium Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Papaya Supreme contains one active ingredient: papain, an enzyme derived from papaya fruit that's been used traditionally to support digestion and tissue health. The product also contains inactive ingredients — calcium carbonate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, hydroxymethyl cellulose, and maltodextrin — which are fillers and binders that give the tablet its form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Papain product and its label doesn't state a use — see Papain's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for papain is insufficient to establish whether it works for the conditions it's marketed for — cancer support, dental caries, radiation dermatitis, exercise-induced muscle soreness, herpes zoster (shingles), and intestinal parasites. The data we hold doesn't show reliable proof it's effective for any of these uses.

If you're considering it for a specific health concern, talk it over with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated when you take it at standard doses for short periods. But it may irritate your digestive tract or trigger allergic reactions in sensitive people — symptoms can include an itchy runny nose, sneezing, abdominal cramps, watery eyes, sweating, and diarrhea.

High oral doses may be unsafe and could cause severe stomach inflammation or even a tear in the esophagus, though these are rare. Concentrated papain and unripe papaya products are not advised in pregnancy because of safety concerns.

There isn't enough data to know whether supplemental papain is safe while breastfeeding, so it's best to avoid it then. If you're pregnant or nursing and want to use this product, talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any other blood thinner, check with your doctor or pharmacist before starting this product — papain may increase bleeding risk by strengthening the thinner's effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Papain is generally well tolerated as a food, but as a concentrated supplement it may upset your stomach or cause allergic reactions in sensitive people. The big caution is if you take warfarin or other blood thinners — papain can strengthen their effects and increase bleeding risk, so check with your doctor or pharmacist first.

Avoid it in pregnancy, and don't use it while breastfeeding unless your healthcare provider says it's okay. The evidence for what it claims to do isn't established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Supreme, straight from the product label.

Brand Swanson Premium Brand
Barcode (UPC) 087614012797
Net contents 300 Tablet(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 184388
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Supreme by Swanson Premium Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
150
UPC/BARCODE
087614012797
IngredientAmount% DV
Papain100 mg--

Other ingredients: Calcium Carbonate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Hydroxymethyl Cellulose, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bringing wellness to the world since 1969

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Warning: Do not take this product if you are pregnant or nursing.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two tablets with water immediately before or after each meal.

General

SW279 Rev 0 07 11 17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Supreme by Swanson Premium Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Supreme by Swanson Premium Brand

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container150 Amounts shown are per serving.

Papain

Interacts with
2 drugs
100 mg per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Calcium Carbonate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Hydroxymethyl Cellulose, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Supreme by Swanson Premium Brand Drug Interactions

Want to check YOUR meds against Papaya Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Papaya Supreme interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Papaya Supreme interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Supreme, from the product label.

Swanson Premium Brand

See all Swanson Premium Brand products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Papaya Supreme by Swanson Premium Brand: Common Questions

Does Papaya Supreme by Swanson Premium Brand interact with any medications?
Yes. Based on its ingredients, Papaya Supreme has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Supreme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Papaya Supreme if I'm on warfarin?
Not without checking first. Papain may boost warfarin's blood-thinning effects and raise your bleeding risk. One case report shows a patient's blood levels spiked dangerously after taking papaya supplements. Talk with your doctor or pharmacist before combining them.
Does papain actually help with digestion?
The evidence isn't established enough for us to say it works. While it's used traditionally for digestion, the data we hold doesn't show reliable proof it's effective for any of the conditions listed — including muscle soreness, shingles, parasites, or cancer support.
Is papain safe to use long-term?
It's generally well tolerated at normal doses for short periods. High doses may be unsafe and could cause serious stomach damage. Allergic reactions and digestive upset can happen, especially in sensitive people.
Can I take this while pregnant?
No — concentrated papain and unripe papaya products are not advised in pregnancy due to safety concerns. If you're pregnant and want to use papaya, talk with your doctor or pharmacist about what's safe for you.
Is it safe while breastfeeding?
There isn't enough data to know either way. It's best to avoid supplemental papain while nursing unless your doctor or pharmacist tells you it's okay for your situation.
What are the common side effects?
In sensitive people, papain can cause allergic reactions — itchy watery eyes, sneezing, runny nose, abdominal cramps, sweating, and diarrhea. It may also irritate the digestive tract. Serious effects like severe stomach inflammation are rare but possible at high doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papaya Supreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Supreme label
Go deeper

The Full Monographs Behind Papaya Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papaya Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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