Passionflower Ingredients & Drug Interactions
by Herb Pharm
What is this page for?
First and foremost: checking Passionflower against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Passionflower is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passionflower Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Passionflower by Herb Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Passionflower by Herb Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Passionflower by Herb Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: passionflower aerial parts extract. The liquid comes suspended in cane alcohol and distilled water.
Does it work?
Moderate evidence
Passionflower is rated possibly effective for two uses: calming nerves before a medical procedure (pre-procedural anxiety) and helping with sleep (insomnia). For ADHD and benzodiazepine withdrawal, the evidence isn't established enough in the data we hold to rate how well it works.
How safe is it?
Well-documented data
Passionflower is generally well tolerated when used short-term, though drowsiness is a common side effect — you may also notice dizziness, confusion, or heightened sensitivity. A small number of trial participants reported allergy-like symptoms including sinus irritation; one case report described a severe reaction (rash and blood vessel inflammation), though it's unclear if passionflower alone was responsible.
There's also a rare case of someone experiencing severe nausea, vomiting, and heart rhythm changes at very high doses, all of which resolved once the supplement was stopped. The safety data advises against passionflower during pregnancy due to lack of safety data and possible effects on the uterus.
There isn't enough safety information to know whether it's okay while breastfeeding — talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
If you take sedatives, anti-anxiety medications, or other central nervous system depressants, double-check with your doctor or pharmacist before starting passionflower — it can make their drowsy effects stronger (Moderate concern). Also confirm with your pharmacist if you take drugs that rely on the OATP transporter system or those broken down by the CYP3A4 enzyme, as passionflower may affect how well they work (Minor concern).
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're looking for help with sleep or pre-procedure jitters, passionflower may be worth trying — the evidence suggests it can help. The main catch is that it makes you drowsy, so don't drive or operate machinery after taking it.
If you take sedatives, blood pressure drugs, heart medications, or anything that your liver processes heavily, check your exact medications with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Passionflower, straight from the product label.
| Brand | Herb Pharm |
|---|---|
| Barcode (UPC) | 090800000041 |
| Net contents | 1 Fluid Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 307810 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Passionflower by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Passionflower Aerial Parts Extract | 619 mg | -- |
Other ingredients: Cane Alcohol, Water, Distilled
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use Shake well before using Adults: Add 1 squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 5 times per day. Best taken between meals.
Precautions
Keep out of the reach of children
Storage
Store away from heat & light
Formula
Passiflora incarnata
Passionflower liquid extract
Formulation
Nervous system Calming & relaxing
Gluten-free
Certified organic by Organic Certifiers
Seals/Symbols
USDA Organic
FDA Statement of Identity
Herbal Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Passionflower by Herb Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Passionflower by Herb Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.
Passionflower Aerial Parts Extract
Interacts with836 drugs
Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...
Passionflower Aerial Parts Extract monograph & interactionsOther (inactive) ingredients: Cane Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.
Passionflower by Herb Pharm Drug Interactions
HelloPharmacist Interaction Report
Herb Pharm's Passionflower can interact with medications, primarily through its single active ingredient, passionflower aerial parts extract.
The most serious interaction is with central nervous system (CNS) depressants — drugs that calm the brain and nervous system, like sedatives and anti-anxiety medications. Taking passionflower with these can add up, meaning you may feel more drowsy, sedated, or impaired than either one alone.
Read the full breakdown — every affected drug type, severity by severity
Passionflower may also affect how your body processes certain other medications. It can theoretically reduce levels of drugs that rely on OATP transporters (a cellular delivery system) — a Minor concern — and may decrease the effects of drugs that are broken down by the CYP3A4 enzyme, though the effect is thought to be small.
Additionally, if you take any prescription or over-the-counter medication, run it through the checker on this page to see if it's one of the ones affected. Altogether, these interactions span 837 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Passionflower?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Passionflower interact with 836 drugs. Click any drug to see the details.
1 of the 1 ingredient in Passionflower interact with drugs. Each result below shows which ingredient is responsible. Passionflower Aerial Parts Extract
AmitriptylineElavil
How Amitriptyline interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Amitriptyline, Perphenazine interactionAmobarbitalAmytal
How Amobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Amobarbital, Secobarbital interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aprobarbital, Butabarbital, Phenobarbital interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Aripiprazole Lauroxil interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Hydrocodone interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Aspirin, Pentazocine interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Atropine, Morphine Sulfate interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Passionflower — through 1 ingredient. Tap an ingredient for the detail:
Passionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladona Extract, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Passionflower with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Passionflower Aerial Parts Extract
Cns Depressants
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.
Brand information
Manufacturer and brand details for Passionflower, from the product label.
Herb Pharm
See all Herb Pharm products- Name
- Herb Pharm
- City
- Williams
- State
- OR
- ZipCode
- 97544
- Phone Number
- 800-348-4372
- Web Address
- www.herb-pharm.com
Passionflower by Herb Pharm: Common Questions
Does Passionflower by Herb Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will passionflower make me drowsy?
Is it safe to take while pregnant or breastfeeding?
Can passionflower help me sleep?
What's in this liquid?
Can I take it before a medical procedure to calm my nerves?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Passionflower is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Passionflower’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Passionflower's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 19 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Passion Flower 19 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
- Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
- Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
- Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
- Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
- Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
- Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
- Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
- Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
- Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
- Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
- Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
- Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
- Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
- da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
- Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
- Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC