Perimine Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking Perimine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Perimine is a dietary supplement by Metagenics with 1 active ingredient. Its ingredients are commonly taken for seasonal and food allergies, asthma and airway inflammation, atopic dermatitis (eczema).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Perimine by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Perimine contains a single active ingredient: perilla seed extract. Perilla is a plant used traditionally in Asian cuisines and herbal practice.
The product also includes inactive ingredients — microcrystalline cellulose, stearic acid, sodium starch glycolate, silica, and magnesium stearate — which are common tablet binders and fillers.
Does it work?
Not established
The evidence for perilla seed extract is still developing. Our data shows insufficient reliable evidence to rate its effectiveness for age-related cognitive decline, allergic rhinitis (hay fever), asthma, osteoporosis, cancer, and headache.
That means research so far hasn't established whether it works for these uses — not that it doesn't work, just that we don't have solid proof yet.
How safe is it?
Well-documented data
Orally, perilla seed extract is generally well tolerated as a food, but supplement-strength products haven't been studied extensively. A rare but serious concern is anaphylaxis (a severe allergic reaction) — many cases have been reported in adults and children who consumed perilla seeds, and some research points to a compound called oleosin as the likely culprit.
Topically, dermatitis (skin irritation) has been reported. Additionally, breathing in smoke from roasted perilla seeds can trigger occupational asthma in some people.
The safety data advises against taking medicinal amounts during pregnancy or while breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for the perilla seed extract in Perimine. That said, check your exact medications using the search tool on this page before you start, and talk with your doctor or pharmacist if you have any concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Perimine is a single-ingredient supplement with no documented drug interactions. However, perilla hasn't been well studied at supplement doses, and anaphylaxis — though rare — is a documented risk if you're allergic to it.
If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist first, especially if you have a known seed allergy.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Perimine, straight from the product label.
| Brand | Metagenics |
|---|---|
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 267291 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Perimine by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Perilla Seed Extract | 100 mg | -- |
Other ingredients: Microcrystalline Cellulose, Stearic Acid, Sodium Starch Glyconate, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Perimine features a patented extract of perilla seed (Perilla frutescens), a unique herb traditionally used to promote healthy respiratory and immune function. Perilla seed extract features a concentrated blend of biologically active flavonoids, including luteolin and rosmarinic acid.
Suggested/Recommended/Usage/Directions
Directions: Take one tablet twice daily with food or as directed by your healthcare practitioner.
Formulation
This product is non-GMO, gluten-free, and vegetarian. GF Certified Gluten-free
This product is non-GMO, gluten-free, and vegetarian.
Traditional support for respiratory health
Precautions
Caution: If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.
Keep out of the reach of children.
Practitioner exclusive
Storage
Storage: Keep tightly closed in a cool, dry place.
Seals/Symbols
GF Certified Gluten-free
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
U.S. Patent #6,217,875
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Perimine by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Perimine by Metagenics
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Perilla Seed Extract
No knowninteractions
Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human ev...
Perilla Seed Extract monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Sodium Starch Glyconate, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Perimine by Metagenics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Perimine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Perimine, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Gig Harbor
- State
- WA
- ZipCode
- 98332
- Phone Number
- 800 692 9400
Perimine by Metagenics: Common Questions
Does Perimine by Metagenics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Perimine if I'm pregnant or breastfeeding?
What are the side effects I should watch for?
Does Perimine actually work for hay fever, asthma, or cognitive decline?
Is perilla seed extract safe at supplement doses?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Perimine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Perimine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Perimine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Perilla 4 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
- Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
- Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC