No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

PhosphaLine Ingredients & Drug Interactions

by XYMOGEN

PhosphaLine label
See full label image
Softgel Capsule Category: Fat/fatty Acid
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PhosphaLine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

PhosphaLine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of PhosphaLine by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PhosphaLine contains 3 active ingredients: phosphatidylcholine, polyunsaturated fat, and monounsaturated fat. Phosphatidylcholine is a natural compound found in cell membranes that supports liver health and brain function.

The product also includes gelatin and ethanol as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Phosphatidylcholine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and brain support.
  • We looked for evidence on: Memory, Dementia, Alzheimer disease, cognitive function, acetylcholine synthesis.
  • The closest evidence on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Memory, Dementia.

Phosphatidylcholine is possibly effective for ulcerative colitis (inflammatory bowel condition). For nonalcoholic fatty liver disease (fatty buildup in the liver not from alcohol), alcohol-related liver disease, Alzheimer disease, and anxiety, the evidence available isn't solid enough yet to rate how well it works.

The evidence, ingredient by ingredient Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylcholine is generally well tolerated. The most common side effects when taken by mouth are altered taste, bloating, diarrhea, itching, nausea, sweating, and vomiting — especially at high doses like 30 grams daily.

Choline (a component of phosphatidylcholine) is needed during pregnancy, but supplement safety beyond what you'd get from food hasn't been well studied; talk with your doctor before taking it while pregnant. There isn't enough reliable data on this supplement during breastfeeding — check with your healthcare provider first.

Side effects, ingredient by ingredient Phosphatidylcholine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Polyunsaturated fat and monounsaturated fat have no interaction data on file.

Talk with your pharmacist before combining this product with any medications you take.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

PhosphaLine may be worth considering if you have ulcerative colitis or are interested in liver support, since phosphatidylcholine shows some promise there. If you're pregnant, breastfeeding, or have a sensitive stomach, talk it over with your doctor or pharmacist first.

No medication interactions are documented for the ingredients we checked, but verify your exact medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PhosphaLine, straight from the product label.

Brand XYMOGEN
Net contents 300 Softgel(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5960
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PhosphaLine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
300
IngredientAmount% DV
Calories9 {Calories}--
Calories from Fat8 {Calories}--
Total Fat0.8 g1%
Saturated Fat0.06 g1%
Polyunsaturated Fat0.19 g--
Monounsaturated Fat0.59 g--
Phosphatidylcholine900 mg--

Other ingredients: Gelatin, Ethanol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2-3 capsules per day or as directed by your healthcare practitioner.

Precautions

CAUTION: Keep out of reach of children.

• Pharmaceutical Grade • Professional Use Only

TAMPER RESISTANT: Do not use if safety seal is broken or missing.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORAGE: Keep tightly closed in a dry place at controlled room temperature 15(0)-30(0)C (59(0)-86(0)F).

General Statements

100% Pure Phosphatidylcholine Concentrate

Each softgel contains: 900 mg Pure Polyenylphosphatidylcholine (PPC). PPC contains no other phospholipids that may compete for absorption. Studies show PPC ingestion increases choline levels in the blood and brain and supports acetylcholine synthesis for proper neuronal and cell function. Daily supplementation of PPC may support and maintain healthy brain and liver function, healthy cholesterol levels, and gastric mucosal protection. As a daily membrane therapeutic, PPC is widely used as an anti-aging supplement.*

Made in Germany

This package is completely recyclable (recycle)

EXCLUSIVE PROFESSIONAL FORMULAS

Brand IP Statement(s)

XYMOGEN 2009

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, dairy products, artificial colors, sweeteners or preservatives.

General

REV. 090909

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PhosphaLine by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PhosphaLine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PhosphaLine by XYMOGEN

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container300 Amounts shown are per serving.

Phosphatidylcholine

No known
interactions
900 mg per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Other (inactive) ingredients: Gelatin, Ethanol. These complete the product’s ingredient list but are not active constituents.

Interaction report

PhosphaLine by XYMOGEN Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in PhosphaLine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for PhosphaLine, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
725 S. Kirkman Rd.
City
Orlando
State
FL
ZipCode
32811
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

PhosphaLine by XYMOGEN: Common Questions

Does PhosphaLine by XYMOGEN interact with any medications?
We do not currently list a known interaction for the mapped ingredients in PhosphaLine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
PhosphaLine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylcholine, and what does it do?
Phosphatidylcholine is a natural compound found in cell membranes throughout your body. It plays a role in liver health and brain function. In this product, it's studied mainly for ulcerative colitis and fatty liver conditions.
Can I take PhosphaLine while pregnant?
Choline, a component of phosphatidylcholine, is needed during pregnancy. However, supplement safety beyond what you get from food sources hasn't been well studied in pregnancy. Talk with your doctor before starting this product.
Can I take PhosphaLine while breastfeeding?
There isn't enough reliable data on this supplement during breastfeeding. Speak with your healthcare provider first to make sure it's right for you.
What side effects might I experience?
The most common side effects when taken by mouth are altered taste, bloating, diarrhea, itching, nausea, sweating, and vomiting — especially at high doses. These are usually mild, but if you have digestive upset, lower your dose or talk with your pharmacist.
Is PhosphaLine effective for Alzheimer disease or anxiety?
The evidence for phosphatidylcholine in Alzheimer disease and anxiety isn't solid enough yet to say how well it works. More research is needed.
Does this product interact with my medications?
No interactions are documented in our data for phosphatidylcholine, the ingredient we could check. But run your exact medications through the search tool on this page, and ask your pharmacist if you have questions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PhosphaLine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PhosphaLine label
Go deeper

The Full Monographs Behind PhosphaLine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph →
Sources

Sources & How We Checked

PhosphaLine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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