No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Phosphatidyl Choline Ingredients & Drug Interactions

by Thorne

Phosphatidyl Choline label
See full label image
Softgel Capsule Category: Fat/fatty Acid
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidyl Choline against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Phosphatidyl Choline is a dietary supplement by Thorne with 1 active ingredient. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Phosphatidyl Choline by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylcholine, a compound found naturally in cell membranes and in foods like eggs and soybeans. The capsule also contains bovine gelatin, purified water, and glycerin as inactive ingredients to hold everything together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: liver and detox support.
  • We looked for evidence on: Alcohol-related liver disease, Hepatic encephalopathy, Hepatitis A, Hepatitis B, Hepatitis C, Nonalcoholic fatty liver disease (NAFLD) — and 3 related terms.
  • The closest evidence on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alcohol-related liver disease (Natural Medicines).
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Hepatic encephalopathy, Hepatitis C, Hepatitis A, Hepatitis B, and more.

Phosphatidylcholine is possibly effective for ulcerative colitis — an inflammatory bowel condition. For nonalcoholic fatty liver disease (NAFLD), alcohol-related liver disease, Alzheimer disease, and anxiety, the evidence we hold is insufficient to rate whether it works.

If you're considering it for any of these conditions, your doctor can help you weigh what the research shows so far.

The evidence, ingredient by ingredient Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylcholine is generally well tolerated when taken by mouth. At high doses — especially 30 grams per day — it may cause digestive upset and diarrhea; smaller doses have also triggered bloating, diarrhea, altered taste, nausea, vomiting, sweating, and itching in some people.

Choline is needed during pregnancy, but safety data for supplement use beyond food sources is limited — check with your doctor before taking this while pregnant. There isn't enough reliable data on supplement use while breastfeeding; talk with your healthcare provider first.

Side effects, ingredient by ingredient Phosphatidylcholine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we checked. Still, it's always smart to confirm with your doctor or pharmacist that it's right for you alongside your other medications.

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Phosphatidyl Choline may be worth considering if you have ulcerative colitis and want to explore supportive options alongside your doctor's care. No medication interactions are documented, but it can cause digestive side effects at higher doses.

If you're pregnant or breastfeeding, or if you're taking any medications, discuss this with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidyl Choline, straight from the product label.

Brand Thorne
Barcode (UPC) 693749605010
Net contents 60 Gelcap(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306276
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidyl Choline by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gelcap(s)
Maximum serving Sizes:
1 Gelcap(s)
Servings per container
60
UPC/BARCODE
693749605010
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat1 Gram(s)1%
Phosphatidylcholine420 mg--

Other ingredients: Bovine Gelatin, Water, Purified, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Foundational Liver/Detox

Gluten free

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 gelcap two to three times daily or as recommended by your healthcare practitioner.

Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Contains ingredient derived from soy.

Storage

Store tightly sealed in a cool, dry place.

Seals/Symbols

Manufactured in the USA using US & imported ingredients

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidyl Choline by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidyl Choline label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidyl Choline by Thorne

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gelcap(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Phosphatidylcholine

No known
interactions
420 mg per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Water, Purified, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidyl Choline by Thorne Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Phosphatidyl Choline. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Phosphatidyl Choline, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

Phosphatidyl Choline by Thorne: Common Questions

Does Phosphatidyl Choline by Thorne interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Phosphatidyl Choline. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Phosphatidyl Choline contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Choline is needed during pregnancy, but we don't have enough safety data on supplement doses beyond what you'd get from food. Talk with your doctor before taking this while pregnant — they can give you personalized advice based on your situation.
Is it safe to take while breastfeeding?
There isn't enough reliable data on supplement use while breastfeeding. Speak with your healthcare provider first to decide what's best for you and your baby.
What side effects might I notice?
Most people tolerate it well, but you might experience altered taste, bloating, diarrhea, nausea, or sweating — especially at higher doses. Very high doses (30 grams a day) are more likely to cause digestive upset.
Does it actually work for ulcerative colitis?
The evidence suggests it's possibly effective for ulcerative colitis. For other conditions listed here — like fatty liver disease, Alzheimer disease, or anxiety — we don't have enough reliable data to know whether it helps.
What is phosphatidylcholine?
It's a natural compound found in cell membranes and in foods like eggs and soybeans. Your body uses it as a building block for healthy cells and nerve function.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidyl Choline is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidyl Choline label
Go deeper

The Full Monographs Behind Phosphatidyl Choline’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph →
Sources

Sources & How We Checked

Phosphatidyl Choline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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