Plantizyme Ingredients & Drug Interactions
by Thorne
What is this page for?
First and foremost: checking Plantizyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Plantizyme is a dietary supplement by Thorne with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Plantizyme by Thorne
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Plantizyme contains five active ingredients, all digestive enzymes: amylase (which we couldn't fully check), protease, lipase, lactase, and cellulase. These enzymes are designed to break down different components of food — proteins, fats, carbohydrates, and plant fiber — to support digestion.
The product also contains inactive ingredients: hypromellose, leucine, and silicon dioxide, which are capsule materials and flow agents.
Does it work?
Strong evidence
The evidence on these enzymes is mixed. Lactase is effective for lactose intolerance — if you can't digest milk sugar, lactase can help.
For the others — protease, lipase, and cellulase — the evidence isn't established in our data. For inflammatory bowel disease and general dyspepsia (indigestion), the research is too sparse to draw a solid conclusion.
Amylase and cellulase effectiveness ratings aren't in our data either.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated in supplement form, though some people report digestive upset. Rare cases of allergic reactions to protease have been documented in occupational settings with airborne exposure; if you have a known enzyme sensitivity, mention it to your pharmacist.
During pregnancy, protease safety hasn't been established and is best avoided unless prescribed; lipase has limited pregnancy data, so check with your doctor; lactase is likely safe but confirm first. For breastfeeding, protease and lipase both have little safety data — talk to your healthcare provider before regular use.
Lipase can cause serious digestive effects in premature infants when added to formula or breast milk, but this product is a standard adult supplement.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Run your medications through the tool on this page to be sure, and if you're ever unsure, ask your pharmacist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
Plantizyme is a straightforward digestive enzyme blend suited for anyone looking to support their digestion — particularly if you struggle with lactose. No medications are known to interact with it based on our data.
If you're pregnant, breastfeeding, or have a serious digestive condition, confirm with your doctor or pharmacist that it's right for you before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Plantizyme, straight from the product label.
| Brand | Thorne |
|---|---|
| Barcode (UPC) | 693749403029 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 306248 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Plantizyme by Thorne, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 850 mg | -- |
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
Other ingredients: Hypromellose, Leucine, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
GI support
Gluten-free
Suggested/Recommended/Usage/Directions
Suggested use: Take 1-2 capsules with each meal or as recommended by your health-care practitioner.
Precautions
Tamper evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Do not take this product out of the capsule.
Storage
Store tightly sealed in a cool, dry place.
Seals/Symbols
Manufactured in the USA using US & imported ingredients
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Plant-based enzymes
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Plantizyme by Thorne label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Plantizyme by Thorne
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Hypromellose, Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Plantizyme by Thorne Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Plantizyme. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Plantizyme, from the product label.
Plantizyme by Thorne: Common Questions
Does Plantizyme by Thorne interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will Plantizyme help my lactose intolerance?
Is it safe to take during pregnancy?
Can I breastfeed while taking this?
What are the inactive ingredients?
Can I be allergic to these enzymes?
What if I have a serious digestive condition?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Plantizyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Plantizyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Plantizyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC