Major interaction on record — check this product against your medications before combining. Based on 6 of 10 ingredients. Check your meds →
Dietary supplement

Poly-MVA Palladium Lipoic Complex Ingredients & Drug Interactions

by AMARC Enterprises

Poly-MVA Palladium Lipoic Complex label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Poly-MVA Palladium Lipoic Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Poly-MVA Palladium Lipoic Complex is a dietary supplement by AMARC Enterprises with 10 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 454 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl Cysteine, Alpha Lipoic Acid, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Poly-MVA Palladium Lipoic Complex by AMARC Enterprises

Ask about any prescription or over-the-counter medication and we check it for interactions with Poly-MVA Palladium Lipoic Complex by AMARC Enterprises — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Poly-MVA Palladium Lipoic Complex by AMARC Enterprises

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 10 active ingredients.
  • “Proprietary Blend (Combination)” is a proprietary blend — the label gives one combined amount (32 mg) without saying how much of each component you get.

Poly-MVA contains 10 active ingredients, including alpha-lipoic acid, vitamin B12, thiamine (vitamin B1), riboflavin (vitamin B2), and molybdenum—all vitamins and minerals with roles in energy production and nerve function. It also contains N-acetyl cysteine, a compound that supports respiratory health and acts as a free radical scavenger.

Three other ingredients—palladium, ruthenium, and rhodium—are metals we don't have monograph data for, and formyl methionine is an amino acid derivative. There is also a proprietary blend component.

Inactive ingredients include distilled water, purified water, thiamine hydrochloride, and vitamin B12.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support cellular energy production and overall health.
  • We looked for evidence on: nutritional depletion, chemotherapy recovery, radiation recovery.
  • The closest evidence on file: N-acetyl Cysteine (nac) is rated "Possibly Ineffective" for Postoperative recovery (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy, Radiation exposure.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy.

Evidence for this product's active ingredients is mixed. Alpha-lipoic acid is possibly effective for diabetic nerve damage, high cholesterol, and weight management.

Vitamin B12 is effective for B12 deficiency and likely effective for cyanide poisoning, and possibly effective for canker sores and a nerve pain condition called postherpetic neuralgia. Thiamine is effective for thiamine deficiency and Wernicke-Korsakoff syndrome (a serious brain condition from severe thiamine lack) and possibly effective for menstrual cramps.

Riboflavin's effectiveness for any condition isn't established in our data. Molybdenum is likely effective for molybdenum deficiency, but evidence for acne, anemia, asthma, osteoporosis, or cancer prevention is insufficient.

N-acetyl cysteine is effective for acetaminophen poisoning and certain respiratory and airway conditions, and possibly effective for bronchitis.

The evidence, ingredient by ingredient Vitamin B12 Thiamine Riboflavin Alpha-lipoic Acid Molybdenum N-acetyl Cysteine (nac)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and is best used under medical guidance. It carries safety concerns in pregnancy and breastfeeding—there isn't enough reliable data, so the safety facts advise against it.

Common side effects include headache, heartburn, nausea, and vomiting; rare serious concerns include a condition called insulin autoimmune syndrome. Vitamin B12 is very safe and has no upper limit; it's considered safe during pregnancy and breastfeeding at normal amounts.

Thiamine is generally very safe but is needed during pregnancy and breastfeeding—use only supplement doses your provider advises. Riboflavin is very safe; excess is removed in urine.

It's safe during pregnancy and breastfeeding at recommended amounts. Molybdenum is safe from food and prenatal vitamins but high-dose supplements may cause problems and should be avoided unless your doctor advises otherwise.

N-acetyl cysteine is generally well tolerated at typical doses but discuss it with your doctor before use; its safety in pregnancy hasn't been well studied, and caution is advised while breastfeeding. Common side effects include diarrhea, dry mouth, nausea, and vomiting.

Side effects, ingredient by ingredient Vitamin B12 Thiamine Riboflavin Alpha-lipoic Acid Molybdenum N-acetyl Cysteine (nac)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Alpha-lipoic Acid, Vitamin B12, Riboflavin, Thiamine, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 454 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor about nitroglycerin (especially intravenous or transdermal patches—a Major interaction), blood thinners and antiplatelet drugs, blood pressure medications, chemotherapy drugs (alkylating agents and antitumor antibiotics), thyroid hormone medications, diabetes medications, tetracycline antibiotics, trimethoprim, metformin, the antimalarial chloroquine, and activated charcoal. These interactions range from Major to Minor in severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in B vitamins, antioxidant support, or respiratory health—particularly if you have diabetic nerve pain or a B12 deficiency. However, it carries a serious Major interaction with nitroglycerin and several Moderate interactions with common medications including blood thinners, blood pressure drugs, and chemotherapy.

If you take any prescription medications, especially heart medications, blood thinners, diabetes drugs, or chemotherapy, check with your pharmacist or doctor before starting this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Poly-MVA Palladium Lipoic Complex, straight from the product label.

Brand AMARC Enterprises
Net contents 8 fl. Oz.; 236 mL
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5559
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Poly-MVA Palladium Lipoic Complex by AMARC Enterprises, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 tsp
Maximum serving Sizes:
0.5 tsp
Servings per container
96
IngredientAmount% DV
Alpha Lipoic Acid0 NP--
Vitamin B12460 mcg7666%
Thiamine23 mg1533%
Riboflavin0.45 mg26%
Molybdenum0 NP--
Proprietary Blend (Combination)32 mg--
Palladium0 NP--
Ruthenium0 NP--
N-Acetyl Cysteine0 NP--
Rhodium0 NP--
Formyl Methionine0 NP--

Other ingredients: distilled Water, purified Water, Thiamine Hydrochloride, Vitamin B12

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement for adults take one-half teaspoon daily. For maximum support take up to eight teaspoons daily or as directed by your health care professional. Shake well before using. May mix with water or juice to reduce taste.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in cool dry place or refrigerate after opening.

General Statements

A Mineral, Vitamin and Amino Acid

A portion of the proceeds from the sales of Poly-MVA are used to support clinical research.

LEADING THE WAY TO OPTIMUM HEALTH

Poly-MVA is a uniquely formulated combination of Minerals, Vitamins and Amino acids designed to support cellular energy production and promote overall health by restoring certain nutrients that may be depleted during chemotherapy and radiation.*

Precautions

CAUTION: As with any dietary supplement, seek advice from a health care practitioner prior to use if you are pregnant, nursing or have any medical complications.

The use of nicotine will reduce the effectiveness of this product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Poly-MVA Palladium Lipoic Complex by AMARC Enterprises label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Poly-MVA Palladium Lipoic Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Poly-MVA Palladium Lipoic Complex by AMARC Enterprises

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 tsp Dosage formLiquid Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
460 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Thiamine

Interacts with
3 drugs
23 mg per serving Form: Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Riboflavin

Interacts with
20 drugs
0.45 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Proprietary Blend (Combination)

32 mg per serving

Other (inactive) ingredients: Distilled Water, Purified Water, Thiamine Hydrochloride, Vitamin B12. These complete the product’s ingredient list but are not active constituents.

Interaction report

Poly-MVA Palladium Lipoic Complex by AMARC Enterprises Drug Interactions

Want to check YOUR meds against Poly-MVA Palladium Lipoic Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
454Drugs
1 Major 364 Moderate 89 Minor

Ingredients driving the most interactions

N-Acetyl Cysteine 294
Alpha Lipoic Acid 263
Vitamin B12 20
Riboflavin 20
Thiamine 3

Individual Drug Interactions

The ingredients in Poly-MVA Palladium Lipoic Complex interact with 454 drugs. Click any drug to see the details.

5 of the 10 ingredients in Poly-MVA Palladium Lipoic Complex interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl Cysteine Alpha Lipoic Acid Vitamin B12 Riboflavin Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Poly-MVA Palladium Lipoic Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl Cysteine full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Poly-MVA Palladium Lipoic Complex, from the product label.

AMARC Enterprises

See all AMARC Enterprises products
Name
AMARC Enterprises
City
San Diego
State
CA
ZipCode
91977
Phone Number
(800) 960-6760
Web Address
www.polymva.com
Pharmacist Counseling Corner

Poly-MVA Palladium Lipoic Complex by AMARC Enterprises: Common Questions

Does Poly-MVA Palladium Lipoic Complex by AMARC Enterprises interact with any medications?
Yes. Based on its ingredients, Poly-MVA Palladium Lipoic Complex has a known interaction with 454 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Poly-MVA Palladium Lipoic Complex contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Alpha-lipoic acid—one of the main ingredients—isn't recommended in pregnancy or breastfeeding due to insufficient safety data. The other vitamins and minerals in the product are generally considered safe at normal amounts during pregnancy and breastfeeding, but check with your doctor or midwife before starting any supplement, especially during pregnancy, to get personalized guidance for your situation.
Will this lower my blood sugar?
Alpha-lipoic acid may theoretically increase the risk of low blood sugar if you're already taking diabetes medications, though larger studies haven't shown a meaningful effect on blood glucose on its own. Because it can lower blood sugar, it's best used under medical guidance if you have diabetes or take diabetes drugs.
What are the most common side effects?
The main ingredients are generally well tolerated, but alpha-lipoic acid may cause headache, heartburn, nausea, or vomiting, and N-acetyl cysteine may cause diarrhea, dry mouth, nausea, or vomiting. Most side effects occur at typical doses, and excess from vitamins like B12 and riboflavin is simply removed in your urine.
Is this product effective for nerve damage?
Alpha-lipoic acid is possibly effective for diabetic nerve damage (neuropathy). The other B vitamins and N-acetyl cysteine support nerve and respiratory function, and vitamin B12 is possibly effective for postherpetic neuralgia (nerve pain after shingles), but evidence for the product as a whole for nerve conditions isn't established.
Can I take this with my heart medication?
This depends on which heart medication you take. If you use nitroglycerin (especially as an IV or patch), this product poses a serious risk and should not be combined. For other heart or blood pressure medications, check with your pharmacist or doctor first—several ingredients may interact with blood pressure drugs.
What are the inactive ingredients?
The inactive ingredients are distilled water, purified water, thiamine hydrochloride, and vitamin B12. The product contains no added fillers or binders beyond what's listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Poly-MVA Palladium Lipoic Complex label
Go deeper

The Full Monographs Behind Poly-MVA Palladium Lipoic Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Molybdenum

Molybdenum is an essential trace mineral your body needs in tiny amounts to help certain enzymes work. Most people get enough from a normal diet, so supplements are rarely needed unless a do...

Read the full Molybdenum monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph →
Sources

Sources & How We Checked

Poly-MVA Palladium Lipoic Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 184 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
  22. Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):
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