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Dietary supplement

Potassium Ingredients & Drug Interactions

by Rexall Naturalist

Potassium label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium is a dietary supplement by Rexall Naturalist with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium by Rexall Naturalist

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium by Rexall Naturalist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium by Rexall Naturalist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Potassium” is listed as a grouped ingredient — the label gives one combined amount (99 mg) without saying how much of each component you get.

This product contains 6 active potassium ingredients: potassium bicarbonate, potassium gluconate, potassium chloride, potassium citrate, potassium sulfate, and potassium bitartrate. These are different chemical forms of potassium designed to be absorbed and used by your body.

The supplement also has several inactive ingredients — cellulose, calcium silicate, croscarmellose, and vegetable magnesium stearate — which are fillers and binders that help hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports muscle and nerve health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts don't include effectiveness ratings for potassium. That said, potassium is an essential mineral your body needs for heart rhythm, muscle function, and nerve signaling.

Whether you need a supplement depends on your individual potassium levels and diet — something your doctor can assess with a blood test.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is generally safe, but supplements can cause dangerously high blood levels in some people, especially those with kidney disease or taking certain medications. The most common side effects from oral potassium are stomach upset — abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting.

Serious but rare effects of very high potassium include irregular heartbeats, heart block, low blood pressure, and confusion. If you're pregnant, dietary potassium is fine, but use supplements only under medical guidance.

Same goes for breastfeeding — check with your doctor first before using a potassium supplement.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Rexall Naturalist Potassium, double-check your medications with your doctor or pharmacist if you take potassium-sparing diuretics (water pills that retain potassium), ACE inhibitors, or ARBs. All three types carry a Moderate risk of high blood potassium when combined with this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Potassium supplements are generally well tolerated but carry real risks if you take certain blood pressure or water pills, or if you have kidney problems. If you're on any heart or blood pressure medication, or if kidney disease is a concern, talk with your doctor or pharmacist before starting this supplement.

They can check your blood potassium level and advise whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium, straight from the product label.

Brand Rexall Naturalist
Barcode (UPC) 030768681470
Net contents 150 Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71755
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium by Rexall Naturalist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
030768681470
IngredientAmount% DV
Potassium99 mg3%
Potassium Bicarbonate0 NP--
Potassium Gluconate0 NP--
Potassium Chloride0 NP--
Potassium Citrate0 NP--
Potassium Sulfate0 NP--
Potassium Bitartrate0 NP--

Other ingredients: Cellulose, Calcium Silicate, Croscarmellose, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Value size

Multi-source

100% satisfaction guaranteed Supports muscle and nerve health

Important facts you should know Potassium is a vital electrolyte which helps regulate nerve signals from the brain and spinal cord to muscles. In addition to supporting muscle activity, Potassium works with sodium to regulate fluid balance in the body. Potassium also aids in the mineral balance of the blood, and helps maintain healthy cell function.

Actual size

Brand IP Statement(s)

Since 1903 Rexall

2016

Formula

Provides 99 mg or elemental Potassium

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal and a full glass of water.

Formulation

No yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium.

Vegetarian formula

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Storage

Store at room temperature and avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod. No. 68147 A0981 00A B52881

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium by Rexall Naturalist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium by Rexall Naturalist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Potassium

Interacts with
62 drugs
99 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Cellulose, Calcium Silicate, Croscarmellose, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium by Rexall Naturalist Drug Interactions

Want to check YOUR meds against Potassium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium, from the product label.

Rexall Naturalist

See all Rexall Naturalist products
Name
Dolgencorp, LLC
Street Address
100 Mission Ridge
City
Goodlettsville
State
TN
ZipCode
37072
Phone Number
1-866-473-9255
Web Address
Rexall.com
Pharmacist Counseling Corner

Potassium by Rexall Naturalist: Common Questions

Does Potassium by Rexall Naturalist interact with any medications?
Yes. Based on its ingredients, Potassium has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are all the different potassium forms in this product?
This tablet contains six potassium compounds: potassium bicarbonate, gluconate, chloride, citrate, sulfate, and bitartrate. They're different chemical forms that your body can absorb and use, though the facts don't explain why one form might be chosen over another.
Can I take this while pregnant or breastfeeding?
Potassium from your normal diet is fine during pregnancy and breastfeeding. The facts say supplements are likely safe, but you should use them only under medical guidance during pregnancy and check with your doctor before using them while breastfeeding.
What are the most common side effects?
Most people who take oral potassium experience stomach upset — things like belly pain, belching, diarrhea, bloating, nausea, or vomiting. These are the usual complaints, though more serious effects like irregular heartbeats are rare and tied to dangerously high blood potassium levels.
Who shouldn't take this supplement?
The facts highlight that potassium supplements can cause dangerously high blood levels in people with kidney disease. If you have kidney problems or take water pills, blood pressure meds, or heart medications, your doctor or pharmacist needs to clear this first.
Does it matter that there are six different potassium forms in one tablet?
The product facts don't explain the reasoning behind including multiple potassium compounds. From a safety and interaction standpoint, they all carry the same risks with blood pressure and water pills.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium label
Go deeper

The Full Monographs Behind Potassium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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