Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Probiotic Acidophilus With Citrus Pectin Ingredients & Drug Interactions

by Rexall Naturalist

Probiotic Acidophilus With Citrus Pectin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Acidophilus With Citrus Pectin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Probiotic Acidophilus With Citrus Pectin is a dietary supplement by Rexall Naturalist with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 316 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L. acidophilus, B. bifidum, L. bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Proprietary Blend of Cultures” is a proprietary blend — the label gives one combined amount (79 mg) without saying how much of each component you get.

This product contains 6 active ingredients: calcium, citrus pectin, and a proprietary blend of four live probiotic cultures (L. acidophilus, B. bifidum, L. salivarius, and L. bulgaricus). The inactive ingredients are gelatin, maltodextrin, vegetable magnesium stearate, and calcium silicate—common capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports intestinal health and microflora balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

Calcium in this product is effective for kidney failure, dyspepsia (indigestion), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and likely effective for osteoporosis. Citrus pectin is possibly effective for high cholesterol, though evidence is limited; for prediabetes and radiation exposure, we don't hold enough data to rate it.

The probiotic cultures are possibly effective for irritable bowel syndrome, H. pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis (L. acidophilus); for IBS and respiratory tract infections (B. bifidum); and for antibiotic-associated diarrhea (L. bulgaricus). For most other conditions listed in the data, evidence is too limited or the cultures are ineffective.

The evidence, ingredient by ingredient Calcium Pectin Lactobacillus Acidophilus Bifidobacterium Bifidum Lactobacillus Delbrueckii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems—most commonly belching, constipation, diarrhea, flatulence, or stomach upset. Rare serious concerns include kidney stones and calciphylaxis.

Very high calcium intake (over 1500–2000 mg/day) may be linked to increased prostate cancer risk and possibly cardiovascular disease, though results are debated. Citrus pectin from food and typical supplement amounts is generally well tolerated; common side effects are diarrhea, gas, loose stools, and mild cramps.

Allergic reactions (rarely anaphylaxis) can occur in sensitive people. The probiotic cultures are generally well tolerated in healthy adults but may cause bloating, flatulence, abdominal pain, or diarrhea; rare serious infections have been reported only in critically ill or immunocompromised patients.

In pregnancy, adequate calcium is important—stay within recommended amounts unless your doctor advises otherwise. Citrus pectin in food amounts is fine, but concentrated supplement safety in pregnancy hasn't been well studied; check with your doctor.

For L. acidophilus and B. bifidum, pregnancy use is possibly safe, though limited data exist. For L. bulgaricus, limited pregnancy data are available—consult your doctor.

During breastfeeding, calcium needs can be met with recommended amounts; pectin at dietary levels is likely fine but concentrated supplement safety isn't established; probiotic safety data during breastfeeding are not on file.

Side effects, ingredient by ingredient Calcium Pectin Lactobacillus Acidophilus Bifidobacterium Bifidum Lactobacillus Delbrueckii

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Pectin, Calcium, Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 316 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you use HIV medications (dolutegravir, elvitegravir, raltegravir), receive intravenous ceftriaxone, take thyroid hormone (levothyroxine), use heart or blood pressure medications (diltiazem, sotalol), take cholesterol drugs (lovastatin), use tetracycline antibiotics, take digoxin (a heart medication), or use calcipotriene for psoriasis. Also separate any antibiotic doses from this supplement by several hours, since antibiotics can kill the live cultures.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help with calcium intake, cholesterol, and digestive health if you have IBS or are at risk for antibiotic-associated diarrhea. However, if you take HIV medications, thyroid hormone, heart medications, antibiotics, or cholesterol drugs, you need to check your exact medications with your doctor or pharmacist before starting—the calcium and pectin can significantly interfere with how these work.

People who are very ill or have weakened immune systems should also talk with their provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Acidophilus With Citrus Pectin, straight from the product label.

Brand Rexall Naturalist
Barcode (UPC) 030768681548
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71830
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
030768681548
IngredientAmount% DV
Calcium154 mg15%
Citrus Pectin200 mg--
Proprietary Blend of Cultures79 mg--
L. acidophilus0 NP--
B. bifidum0 NP--
L. salivarius0 NP--
L. bulgaricus0 NP--

Other ingredients: Gelatin, Maltodextrin, Vegetable Magnesium Stearate, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

3 billion active cultures per capsule 100% satisfaction guaranteed Supports intestinal health

Since 1903

Important facts you should know Acidophilus is a friendly bacteria naturally found in the intestinal tract. Probiotic Acidophilus supports a favorable environment for nutrients, encourages intestinal microflora balance, and promotes the healthy functioning of the intestinal system. Intestinal microflora imbalance may lead to inefficient digestion.

Actual size

FDA Statement of Identity

Dietary Supplement

Formula

Contains milk ingredients.

Precautions

Contains milk ingredients.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily, with or without a meal.

Formulation

No wheat, gluten, sugar, preservatives, soy, artificial color, artificial flavor, sodium.

Storage

Store unopened container at room temperature and avoid excessive heat.

Refrigerate after opening

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod. No. 68154 A0986 00A B1540

Brand IP Statement(s)

2016

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Acidophilus With Citrus Pectin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
154 mg per serving Form: Dicalcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Citrus Pectin

Interacts with
23 drugs
200 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Citrus Pectin monograph & interactions

Proprietary Blend of Cultures

79 mg per serving

Other (inactive) ingredients: Gelatin, Maltodextrin, Vegetable Magnesium Stearate, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist Drug Interactions

Want to check YOUR meds against Probiotic Acidophilus With Citrus Pectin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
316Drugs
7 Major 291 Moderate 18 Minor

Ingredients driving the most interactions

L. acidophilus 182
B. bifidum 182
L. bulgaricus 182
Calcium 168
Citrus Pectin 23

Individual Drug Interactions

The ingredients in Probiotic Acidophilus With Citrus Pectin interact with 316 drugs. Click any drug to see the details.

5 of the 6 ingredients in Probiotic Acidophilus With Citrus Pectin interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus B. bifidum L. bulgaricus Calcium Citrus Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Acidophilus With Citrus Pectin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

L. bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
L. bulgaricus full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Citrus Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Citrus Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Acidophilus With Citrus Pectin, from the product label.

Rexall Naturalist

See all Rexall Naturalist products
Name
Dolgencorp, LLC
Street Address
100 Mission Ridge
City
Goodlettsville
State
TN
ZipCode
37072
Phone Number
1-866-473-9255
Web Address
Rexall.com
Pharmacist Counseling Corner

Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist: Common Questions

Does Probiotic Acidophilus With Citrus Pectin by Rexall Naturalist interact with any medications?
Yes. Based on its ingredients, Probiotic Acidophilus With Citrus Pectin has a known interaction with 316 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Acidophilus With Citrus Pectin contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my antibiotic?
The probiotic cultures—L. acidophilus, B. bifidum, and L. bulgaricus—can be killed by antibiotics if taken at the same time. Ask your pharmacist to space them out, typically a few hours apart. If you're taking tetracycline antibiotics specifically, the citrus pectin in this product may also reduce how well the antibiotic is absorbed.
Can I take this if I have a weakened immune system?
The facts advise caution for people with weakened immune systems before using the probiotic cultures. Live organisms can rarely cause serious infection in those who are very ill or immunocompromised. Check with your doctor or pharmacist before starting.
What side effects might I notice?
Most common are digestive complaints: bloating, gas, loose stools, mild cramps, or constipation. Allergic reactions to pectin are rare but possible in sensitive people. If you're very ill, there's a rare risk of serious infection from the live probiotics, but this is uncommon in healthy adults.
Is this safe to take while pregnant?
Calcium at recommended amounts is safe in pregnancy. Citrus pectin in food is fine, but concentrated supplement safety hasn't been well studied—ask your doctor. The probiotic cultures are possibly safe in pregnancy, but data are limited, so discuss it with your provider.
Does this really help with IBS?
L. acidophilus and B. bifidum are both rated possibly effective for irritable bowel syndrome based on available evidence. That means some research supports it, but results aren't conclusive. Response varies by person.
Can I take this with my thyroid medication?
The calcium in this product can interfere with how well your body absorbs levothyroxine (thyroid hormone). Your doctor or pharmacist needs to help you space the doses apart—usually at least 4 hours—so they don't interact.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Acidophilus With Citrus Pectin label
Go deeper

The Full Monographs Behind Probiotic Acidophilus With Citrus Pectin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph →
Sources

Sources & How We Checked

Probiotic Acidophilus With Citrus Pectin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
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Pectin 11 references
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See these in context on the Pectin monograph →

Lactobacillus Acidophilus 15 references
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
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See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Delbrueckii 9 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
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  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
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See these in context on the Lactobacillus Delbrueckii monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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