No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Protease 375 Ingredients & Drug Interactions

by ProEnzol

Protease 375 label
See full label image
Capsule Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Protease 375 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Protease 375 is a dietary supplement by ProEnzol with 1 active ingredient. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Protease 375 by ProEnzol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Protease 375 contains one active ingredient: protease, an enzyme that breaks down proteins. It also includes plant fiber and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: protein digestion and systemic enzyme support.
  • We looked for evidence on: Digestive enzyme insufficiency, Protein malabsorption, Systemic inflammation, Post-surgical recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for this product, so I can't tell you whether it works for any particular purpose. If you're considering it for a specific health goal, your pharmacist or doctor can help you weigh the evidence.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated for most adults, but some people report digestive upset or allergic reactions. Rarely, occupational exposure to similar proteolytic enzymes has triggered allergic rhinoconjunctivitis (nasal and eye inflammation) or asthma in people inhaling them.

The product should be avoided during pregnancy unless your doctor prescribes it specifically. During breastfeeding, there isn't enough safety data, so medical advice is needed before use.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for this ingredient. Still, run your exact medications through the checker on this page if you want to be certain.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Protease 375 is a single-ingredient enzyme supplement with no documented drug interactions. Most people tolerate it well, but if you're pregnant, breastfeeding, or have a history of allergies to enzymes, talk with your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Protease 375, straight from the product label.

Brand ProEnzol
Barcode (UPC) 707636127117
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322876
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Protease 375 by ProEnzol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Capsule(s)
Maximum serving Sizes:
1 Vegan Capsule(s)
Servings per container
60
UPC/BARCODE
707636127117
IngredientAmount% DV
Protease375 mg--

Other ingredients: Plant Fiber, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

ProEnzol Protease 375 provides highly purified, non-animal enzymes to augment the body's own enzymes in assimilating dietary protein when taken with meals, and in maintaining healthy cytokine balance and systemic health when taken between meals.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule at the beginning of each meal for digestive support or twice daily on an empty stomach for systemic support, or as directed by your healthcare professional.

Precautions

Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.

Use only if tamper-evident seal is unbroken.

Keep out of reach of children.

Exclusively for professionals

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Augements gastric, pancreatic and intestinal proteolytic enzymes

Contains no: Sugar, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Protease 375 by ProEnzol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Protease 375 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Protease 375 by ProEnzol

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Protease

No known
interactions
375 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Other (inactive) ingredients: Plant Fiber, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Protease 375 by ProEnzol Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Protease 375. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Protease 375, from the product label.

ProEnzol

See all ProEnzol products
Name
Enzymes Inc.
City
Kansas City
State
MO
ZipCode
64153
Phone Number
1-800-637-7893
Web Address
www.proenzol.com
Pharmacist Counseling Corner

Protease 375 by ProEnzol: Common Questions

Does Protease 375 by ProEnzol interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Protease 375. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Protease 375 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No — the safety data advises against protease during pregnancy unless a doctor specifically prescribes it. Talk with your doctor before use.
Is it safe while breastfeeding?
There isn't enough safety data to say either way. You'll need to discuss this with your doctor or pharmacist to make a decision that's right for you.
What does protease do?
Protease is an enzyme that breaks down proteins. Beyond that, we don't have effectiveness data on what it accomplishes for health.
Can protease cause allergic reactions?
Yes — allergic reactions are possible, though not common. People with occupational exposure to similar enzymes have occasionally developed allergies affecting the nose, eyes, or airways. If you have a history of enzyme allergies or respiratory sensitivities, mention it to your pharmacist.
What are the inactive ingredients?
Plant fiber and water. These are fillers and carriers that don't do the work of the supplement itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Protease 375 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Protease 375 label
Go deeper

The Full Monographs Behind Protease 375’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Protease 375's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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