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Dietary supplement

Pumpkin Seed Ingredients & Drug Interactions

by Pure Herbs

Pumpkin Seed label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pumpkin Seed against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pumpkin Seed is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pumpkin Seed by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpkin Seed by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pumpkin Seed by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: Pumpkin Seed Extract. The liquid form delivers the concentrated seed extract, which has traditionally been used for urinary and prostate health.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pumpkin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune function and hair and nail health.
  • We looked for evidence on: Androgenic alopecia, nail health, skin health.
  • The closest evidence on file: Pumpkin is rated "Insufficient Reliable Evidence To Rate" for Androgenic alopecia (Natural Medicines).

The strongest evidence supports pumpkin seed for benign prostatic hyperplasia (BPH) — difficulty urinating related to prostate enlargement — where it's rated possibly effective. For androgenic alopecia (male or female pattern hair loss), interstitial cystitis (chronic bladder pain), intestinal parasite infection, and urinary tract infections, the evidence in our data is insufficient to rate it.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin as a food is generally well tolerated. Concentrated seed-oil supplements like this one are also generally well tolerated in most adults, though the data on safety in concentrated form is less robust than for whole pumpkin.

The most common side effects reported are abdominal discomfort, diarrhea, nausea, and vomiting. Anaphylaxis is rare but has been reported.

There are also two case reports of substantial hair loss 1–3 weeks after eating bitter-tasting pumpkin or squash with high concentrations of cucurbitacin, a compound found mainly in wild varieties. For pregnancy and breastfeeding: we don't hold enough data on concentrated pumpkin seed supplements during either.

Regular pumpkin as food is fine, but talk with your doctor or pharmacist before taking this concentrated supplement if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, do not start this product without checking with your doctor or pharmacist — pumpkin may reduce how your body clears it and cause levels to climb. For all other medications, use the search tool on this page to confirm you're in the clear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pumpkin Seed Extract may help with prostate enlargement symptoms, though evidence for other uses is lacking. It's generally well tolerated but does interact with lithium — if you take that medication, check with your doctor or pharmacist first.

Pregnant and breastfeeding people should talk it over with their own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpkin Seed, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279210
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpkin Seed by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Pumpkin Seed Extract1888 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Helps to support a healthy immune function. Beneficial for nourishment of hair and nails.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pumpkin Seed by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pumpkin Seed label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pumpkin Seed by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Pumpkin Seed Extract

Interacts with
1 drug
1888 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin Seed Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpkin Seed by Pure Herbs Drug Interactions

Want to check YOUR meds against Pumpkin Seed?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Pumpkin Seed Extract 1

Individual Drug Interactions

The ingredients in Pumpkin Seed interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Pumpkin Seed interact with drugs. Each result below shows which ingredient is responsible. Pumpkin Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpkin Seed with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin Seed Extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pumpkin Seed, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Pumpkin Seed by Pure Herbs: Common Questions

Does Pumpkin Seed by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Pumpkin Seed has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpkin Seed contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pumpkin seed extract used for?
Pumpkin seed has been studied most for benign prostatic hyperplasia — trouble urinating caused by prostate enlargement — where there's possibly effective evidence. It's also been looked at for hair loss, bladder pain, parasites, and urinary tract infections, but the evidence there isn't established yet.
What are the most common side effects?
The most common ones are abdominal discomfort, diarrhea, nausea, and vomiting. Most people tolerate it well, but these do show up in trial data and case reports.
Can I take this if I'm pregnant or breastfeeding?
We don't have enough safety data on concentrated pumpkin seed supplements during pregnancy or breastfeeding. Regular pumpkin as food is fine, but talk with your doctor or pharmacist before taking this concentrated form — they can weigh the pros and cons for your situation.
Does pumpkin seed extract have a diuretic effect?
Yes — pumpkin is thought to have diuretic properties, meaning it increases urination. This is actually why it may reduce how your body clears lithium, so it's important to flag if you take that medication.
Are there any inactive ingredients I should know about?
No inactive ingredients are listed for this product — it's just the pumpkin seed extract in liquid form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pumpkin Seed is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpkin Seed label
Go deeper

The Full Monographs Behind Pumpkin Seed’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Pumpkin Seed's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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