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Dietary supplement

Pumpkin Seed Oil 1000 mg Ingredients & Drug Interactions

by GNC

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pumpkin Seed Oil 1000 mg is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin seed oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pumpkin Seed Oil 1000 mg by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: pumpkin seed oil and polyunsaturated fat. Pumpkin seed oil is the star here — it's a concentrated extract from pumpkin seeds that's been studied for prostate and urinary health.

The capsule itself is made from gelatin and glycerin, which are inactive ingredients that hold everything together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH).
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).

Pumpkin seed oil has possibly effective evidence for benign prostatic hyperplasia (BPH) — that's the noncancerous swelling of the prostate that can happen as men age. For other uses listed on the label — androgenic alopecia (male-pattern hair loss), interstitial cystitis (chronic bladder pain), parasite infections, and urinary tract infections — the evidence we have is insufficient to rate it.

That doesn't mean it doesn't work for those; it means the studies aren't solid enough yet to say.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin seed oil is generally well tolerated when taken as a supplement. The most common side effects reported in trials were mild — abdominal discomfort, diarrhea, nausea, and vomiting — and rare cases of anaphylaxis (a severe allergic reaction) have been reported, though this is uncommon.

Eating pumpkin as food is safe, but there isn't enough safety data on concentrated seed supplements during pregnancy and breastfeeding to know either way; talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Lithium (Moderate severity): pumpkin seed oil may reduce how your body clears it, raising levels in your blood. Check with your doctor or pharmacist before starting this product if you take lithium.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GNC Pumpkin Seed Oil may be worth trying if you're dealing with prostate swelling and want a supplement with some evidence behind it. If you take lithium, check with your doctor or pharmacist before starting — you may need a dose adjustment.

Otherwise, run your medications through the checker on this page to be sure, and talk it over with your healthcare provider if you have questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpkin Seed Oil 1000 mg, straight from the product label.

Brand GNC
Barcode (UPC) 048107211752
Net contents 100 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 224785
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpkin Seed Oil 1000 mg by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
UPC/BARCODE
048107211752
IngredientAmount% DV
Calories10 Calorie(s)--
Total Fat1 Gram(s)1%
Polyunsaturated Fat0.5 Gram(s)--
Pumpkin seed oil1000 mg--

Other ingredients: Gelatin, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Supports prostate health

General Statements

100 servings

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one or two softgel capsules daily.

Formulation

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No sugar, no starch, no artificial colors, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no corn, no soy, no dairy. GF Gluten Free

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Pumpkin Seed Oil 1000 mg by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pumpkin Seed Oil 1000 mg by GNC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Pumpkin seed oil

Interacts with
1 drug
1000 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed oil monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpkin Seed Oil 1000 mg by GNC Drug Interactions

Want to check YOUR meds against Pumpkin Seed Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpkin Seed Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin seed oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Pumpkin Seed Oil 1000 mg, from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Pumpkin Seed Oil 1000 mg by GNC: Common Questions

Does Pumpkin Seed Oil 1000 mg by GNC interact with any medications?
Yes. Based on its ingredients, Pumpkin Seed Oil 1000 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpkin Seed Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does pumpkin seed oil really help with an enlarged prostate?
The evidence says possibly — pumpkin seed oil has been rated possibly effective for benign prostatic hyperplasia (the noncancerous swelling that happens with age). It's worth trying, but talk with your doctor about whether it's right for your situation.
What side effects might I experience?
Most people tolerate it well. The most common ones reported in trials were mild abdominal discomfort, diarrhea, nausea, and vomiting. Rarely, anaphylaxis (a severe allergic reaction) has been reported.
Is pumpkin seed oil safe to take while pregnant or breastfeeding?
There isn't enough data on concentrated seed supplements during pregnancy and breastfeeding to know either way. Talk with your doctor or pharmacist for personalized advice before taking it.
What if I eat bitter-tasting pumpkin — is that a problem?
Bitter pumpkin and some squashes can contain high levels of a compound called cucurbitacin, which has caused temporary hair loss and severe nausea, vomiting, and diarrhea in rare cases. This product is purified seed oil, so that risk is much lower, but it's worth knowing.
How many active ingredients are in this?
Two: pumpkin seed oil and polyunsaturated fat. The rest of the capsule is made of gelatin and glycerin, which are inactive ingredients that hold it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pumpkin Seed Oil 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpkin Seed Oil 1000 mg label
Go deeper

The Full Monographs Behind Pumpkin Seed Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Pumpkin Seed Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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