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Dietary supplement

Pure Graviola 1300 mg Ingredients & Drug Interactions

by Biotech Nutritions

Pure Graviola 1300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Graviola 1300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Graviola 1300 mg is a dietary supplement by Biotech Nutritions with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Graviola 1300 mg by Biotech Nutritions

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Graviola 1300 mg by Biotech Nutritions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pure Graviola 1300 mg by Biotech Nutritions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: graviola (also called soursop) at 1300 mg per capsule. It also contains a vegetable capsule as the inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Graviola product and its label doesn't state a use — see Graviola's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for graviola isn't established in the data we hold. The product is studied for human papillomavirus (HPV) infection, headache, male infertility, and insect repellent use, but we have insufficient reliable evidence to rate how well it works for any of those purposes.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Graviola raises some safety concerns that you should know about. Regular use may cause nausea and pain in the upper abdomen.

More seriously — though rare — long-term use has been linked to movement disorders and nerve damage (myeloneuropathy) with symptoms similar to Parkinson disease. People with Parkinson disease seem to experience worsening symptoms even from small amounts of graviola fruit, juice, or tea.

Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding because there isn't enough safety data. Human safety information overall is limited, and lab studies suggest possible nerve toxicity with extended use.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take carbamazepine (Tegretol) or any other anti-seizure medication. Graviola may lower the effectiveness of carbamazepine by reducing how much stays in your bloodstream.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola isn't backed by strong evidence for the conditions it's marketed for, and regular use carries real safety concerns — especially nerve and movement risks with long-term intake. If you take carbamazepine for seizures, this product could interfere with your medication.

Talk with your doctor or pharmacist before starting graviola, and mention it if you're pregnant, nursing, or have any nerve or movement concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Graviola 1300 mg, straight from the product label.

Brand Biotech Nutritions
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244008
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Graviola 1300 mg by Biotech Nutritions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Graviola1300 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two (2) capsules daily or as directed by a healthcare professional.

Precautions

Caution: Not for use by individuals under the age of 18.

Consult a physician before using this or any dietary supplement.

Do not use if you are pregnant, nursing or have a know medical condition.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Pure Graviola 1300 mg per serving

Each capsule contains 650 mgs of 100% pure graviola leaf ground to a fine powder.

Formulation

Gelatin free

The graviola found in this product was harvested in Brazil.

FDA Statement of Identity

Dietary Supplement

General Statements

Order online: www.BiotechNutritions.com

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Graviola 1300 mg by Biotech Nutritions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Graviola 1300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Graviola 1300 mg by Biotech Nutritions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Graviola

Interacts with
1 drug
1300 mg per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Graviola 1300 mg by Biotech Nutritions Drug Interactions

Want to check YOUR meds against Pure Graviola 1300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola 1

Individual Drug Interactions

The ingredients in Pure Graviola 1300 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Pure Graviola 1300 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Graviola 1300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Graviola 1300 mg, from the product label.

Biotech Nutritions

See all Biotech Nutritions products
Name
Biotech Nutritions
Street Address
P.O. Box 865
City
Novi
State
MI
ZipCode
48376
Phone Number
888-662-7001
Web Address
www.BiotechNutritions.com
Pharmacist Counseling Corner

Pure Graviola 1300 mg by Biotech Nutritions: Common Questions

Does Pure Graviola 1300 mg by Biotech Nutritions interact with any medications?
Yes. Based on its ingredients, Pure Graviola 1300 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Graviola 1300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. Graviola is rated possibly unsafe in pregnancy, and there isn't enough safety data to use it while breastfeeding. Talk with your doctor or pharmacist before using this product if you're pregnant, trying to become pregnant, or nursing.
What are the most common side effects?
Nausea and upper abdominal pain are the most common side effects reported in studies. Serious but rare side effects include movement disorders and nerve damage that can look like Parkinson disease.
Should I be concerned about long-term use?
Yes. Lab studies raise concerns about possible nerve toxicity with long-term use, and people with Parkinson disease have reported worsening symptoms even from small amounts of graviola. Talk with your doctor before taking this regularly.
Does this actually work for HPV, headaches, or infertility?
The evidence isn't established. We have insufficient reliable evidence to rate how well graviola works for those conditions or any others it's marketed for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Graviola 1300 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Graviola 1300 mg label
Go deeper

The Full Monographs Behind Pure Graviola 1300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Pure Graviola 1300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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