Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Pure L-Threonine 500 Milligrams Ingredients & Drug Interactions

by Montiff

Pure L-Threonine 500 Milligrams label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure L-Threonine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pure L-Threonine 500 Milligrams is a dietary supplement by Montiff with 1 active ingredient. Its ingredients are commonly taken for general amino acid/protein support, muscle and tissue health, immune support.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Threonine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure L-Threonine 500 Milligrams by Montiff

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure L-Threonine 500 Milligrams by Montiff — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure L-Threonine 500 Milligrams by Montiff

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-threonine, an amino acid at 500 milligrams per capsule. The remaining ingredients — microcrystalline cellulose, magnesium stearate, and gelatin — are inert materials that form and fill the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Threonine product and its label doesn't state a use — see Threonine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for L-threonine is limited. For ALS (Lou Gehrig's disease), it's rated possibly ineffective.

For multiple sclerosis, familial spastic paraparesis, and spasticity, we don't have enough reliable data to know whether it works. The research backing its use for these conditions isn't established in the data we hold.

The evidence, ingredient by ingredient Threonine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Threonine from food is safe, but supplement safety at higher doses hasn't been well studied. Some people report headache or mild stomach upset, including diarrhea, gas, or constipation.

Because supplement use in pregnancy and breastfeeding hasn't been well studied, the safety data advises against it unless a clinician advises otherwise — talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Threonine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Threonine.
  • The most serious interaction on file is rated Major.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use any NMDA antagonists — threonine may reduce their effectiveness. That's the only medication class with documented Major-severity interaction in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a single-ingredient supplement for people interested in threonine for neurological conditions, though the evidence for those uses is weak or absent. It's generally well tolerated at the studied dose, but long-term safety isn't well characterized.

If you take NMDA antagonists or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure L-Threonine 500 Milligrams, straight from the product label.

Brand Montiff
Barcode (UPC) 683268104750
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42069
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure L-Threonine 500 Milligrams by Montiff, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
683268104750
IngredientAmount% DV
L-Threonine500 mg--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one to three capsules daily, or as recommended by a health care professional. To be used as a Dietary supplement in a normal food program. It is recommended that this product be taken with vitamins and minerals.

Formulation

Contains no Starch, Corn, Milk, Wheat, Yeast, Sugar, Eggs, Salt, Artificial Colors, Binders, Flavors, Preservatives or fish derivatives.

Storage

Do Not Refrigerate.

Store in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Product#10475

Brand IP Statement(s)

(C)1999 MONTIFF,INC. ALL RIGHTS RESERVED.

General Statements

MONTIFF

Highest Quality Available

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure L-Threonine 500 Milligrams by Montiff label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure L-Threonine 500 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure L-Threonine 500 Milligrams by Montiff

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Threonine

Interacts with
3 drugs
500 mg per serving

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...

L-Threonine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure L-Threonine 500 Milligrams by Montiff Drug Interactions

Want to check YOUR meds against Pure L-Threonine 500 Milligrams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Major

Ingredients driving the most interactions

L-Threonine 3

Individual Drug Interactions

The ingredients in Pure L-Threonine 500 Milligrams interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure L-Threonine 500 Milligrams interact with drugs. Each result below shows which ingredient is responsible. L-Threonine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure L-Threonine 500 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure L-Threonine 500 Milligrams, from the product label.

Montiff

See all Montiff products
Phone Number
(310) 582-8938
Pharmacist Counseling Corner

Pure L-Threonine 500 Milligrams by Montiff: Common Questions

Does Pure L-Threonine 500 Milligrams by Montiff interact with any medications?
Yes. Based on its ingredients, Pure L-Threonine 500 Milligrams has a known interaction with 3 medications, including 3 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure L-Threonine 500 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I get?
Headache is the most commonly reported side effect. Some people also experience mild stomach upset — diarrhea, gas, or constipation. These are usually minor, but let your pharmacist know if they persist or worsen.
Is L-threonine safe to take while pregnant?
Supplement safety in pregnancy hasn't been well studied, so the data advises against it unless a clinician recommends it. Talk with your doctor or pharmacist about your specific situation before taking it.
Can I take this while breastfeeding?
Threonine supplement use during breastfeeding hasn't been well studied, so there isn't enough data to know either way. Check with your doctor or pharmacist before starting it.
Does L-threonine actually work for ALS or MS?
For ALS, it's rated possibly ineffective. For MS and other spasticity conditions, we simply don't have enough reliable evidence to know if it works. The science backing its use isn't established in the data we hold.
What is L-threonine, and why would someone take it?
L-threonine is an amino acid — a building block your body uses to make proteins. People sometimes try it for neurological conditions like ALS, MS, and spasticity, though the evidence for those uses is weak or missing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure L-Threonine 500 Milligrams is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure L-Threonine 500 Milligrams label
Go deeper

The Full Monographs Behind Pure L-Threonine 500 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph →
Sources

Sources & How We Checked

Pure L-Threonine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
  2. Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
  3. Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

See these in context on the Threonine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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