No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Reduced Glutathione 500 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Reduced Glutathione 500 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin lightening or brightening, detoxification support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Reduced Glutathione 500 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Setria, a form of reduced glutathione at 500 mg per capsule. Glutathione is a compound your body makes naturally; this supplement is meant to raise levels you may get from food or your own production.

The capsule itself is made from vegetable material, and the other ingredients—microcrystalline cellulose, stearic acid, magnesium stearate, and silicon dioxide—are inactive fillers and binders that help hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Glutathione's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Antioxidant and cellular health support.
  • We looked for evidence on: Aging, Chronic fatigue syndrome (CFS), Cirrhosis, Nonalcoholic fatty liver disease (NAFLD), Immune function, Detoxification — and 1 related terms.
  • The closest evidence on file: Glutathione is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Glutathione is rated "Insufficient Reliable Evidence To Rate" for Cirrhosis, Nonalcoholic fatty liver disease (NAFLD), Aging.

The evidence for glutathione is mixed and depends on what you're using it for. It's rated possibly effective for reducing nerve damage (neurotoxicity) caused by the chemotherapy drug cisplatin.

For other uses listed here—nonalcoholic fatty liver disease, Alzheimer disease, athletic performance, and cataracts—the evidence isn't strong enough yet to say whether it works, so those are rated insufficient.

The evidence, ingredient by ingredient Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oral glutathione appears generally well tolerated in the short term, though long-term safety hasn't been as thoroughly studied. During pregnancy, there isn't enough reliable safety data, so it's best avoided unless your doctor says otherwise.

The same goes for breastfeeding—there's not enough information to know it's safe, so caution and avoidance are advised. One note: if you have asthma and use inhaled glutathione (not this oral form), it can cause airway narrowing and shortness of breath, but that doesn't apply to this capsule.

Side effects, ingredient by ingredient Glutathione

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients in this product.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

If you're looking to support glutathione levels or you're exploring it for cisplatin-related nerve damage under your doctor's care, this product has no documented medication interactions. That said, talk with your pharmacist about your personal health picture—especially if you're pregnant, breastfeeding, or taking anything regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Reduced Glutathione 500 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536026029
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183200
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Reduced Glutathione 500 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
766536026029
IngredientAmount% DV
Setria500 mg--

Other ingredients: Vegetable capsule, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Specialty Antioxidant Cellular health Immune

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten free Dairy free Soy free Nut free

Does not contain: Gluten, Sugar, Salt, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) veggie capsule up to three (3) times daily, preferably with meals.

Brand IP Statement(s)

Setria is a registered trademark of KYOWA HAKKO BIO Co., Ltd.

General

Item No. VS-2602 1748714 ES 37

See for yourself

Reduced Glutathione 500 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Reduced Glutathione 500 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Setria

No known
interactions
500 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria monograph & interactions

Other (inactive) ingredients: Vegetable capsule, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Reduced Glutathione 500 mg by The Vitamin Shoppe Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Reduced Glutathione 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Reduced Glutathione 500 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Reduced Glutathione 500 mg by The Vitamin Shoppe: Common Questions

Does Reduced Glutathione 500 mg by The Vitamin Shoppe interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Reduced Glutathione 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Reduced Glutathione 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
The safety data we have isn't enough to know either way. The label advises against it unless your doctor specifically says to take it. Talk with your doctor or pharmacist—they can weigh your situation and give you personalized guidance.
What is Setria?
Setria is a brand name for reduced glutathione, a compound your body produces naturally. It's meant to supplement what you make on your own or get from food.
Does this actually work?
The evidence is strongest for reducing nerve damage from the chemotherapy drug cisplatin, where it's rated possibly effective. For other uses like liver health, Alzheimer disease, athletic performance, and cataracts, the evidence isn't established yet.
Is it safe to take long-term?
Short-term use appears generally well tolerated, but we don't have much data on long-term safety. If you're thinking about taking it regularly, check in with your pharmacist.
Is it safe while breastfeeding?
There isn't enough safety information during breastfeeding, so caution and avoidance are advised. Talk with your doctor or pharmacist about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Reduced Glutathione 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Reduced Glutathione 500 mg label
Go deeper

The Full Monographs Behind Reduced Glutathione 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Reduced Glutathione 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutathione 1 reference
  1. Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed

See these in context on the Glutathione monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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