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Dietary supplement

Renalplex 750 mg Ingredients & Drug Interactions

by Sunshine Naturals

Renalplex 750 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Renalplex 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Renalplex 750 mg is a dietary supplement by Sunshine Naturals with 3 active ingredients. Its ingredients are commonly taken for fluid retention (mild diuretic), urinary and bladder concerns, hair, skin, and nail support.Based on those ingredients, 997 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi, Cranberry, Horsetail. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Renalplex 750 mg by Sunshine Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Renalplex 750 mg by Sunshine Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Renalplex 750 mg by Sunshine Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

Renalplex 750 mg contains 3 active ingredients: horsetail, uva ursi, and cranberry, delivered in a capsule form. These are combined in a proprietary blend, meaning the individual amount of each herb is not disclosed on the label.

The capsules also contain inactive ingredients—rice flour, magnesium stearate, and gelatin—which serve as fillers and binders. Horsetail is traditionally used to support urinary and bone health.

Uva ursi has been used for urinary tract support, and cranberry is commonly taken for urinary health as well. Together, they form a blend marketed for kidney and urinary function.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: urinary tract and kidney health support.
  • We looked for evidence on: Kidney stones (nephrolithiasis), Urinary tract infections (UTIs), Overactive bladder, Urinary incontinence, Urinary odor, Radiation-induced cystitis — and 3 related terms.
  • The strongest evidence on file: Cranberry is rated "Possibly Effective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs).
  • Also on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs), Urinary incontinence.

The evidence for these ingredients is limited. For horsetail, we have insufficient reliable evidence to rate its effectiveness for urinary incontinence, obesity, tonsillitis, or hair loss.

Uva ursi is possibly ineffective for urinary tract infections (UTIs) and has insufficient evidence for bronchitis and benign prostatic hyperplasia (BPH). Cranberry is rated possibly effective for UTIs, but has insufficient evidence for age-related cognitive decline, BPH, cancer, fatty liver disease, and chronic fatigue.

Overall, the clinical support for this product's intended use is not well established in the data we hold.

The evidence, ingredient by ingredient Horsetail Uva Ursi Cranberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horsetail is generally well tolerated short-term in healthy adults, but long-term use carries real risks. Common side effects include abdominal bloating, increased bowel movements, and nausea.

Importantly, crude horsetail contains thiaminase, which can cause thiamine (vitamin B1) deficiency with prolonged use, though Canadian products are required to be thiaminase-free. One rare case of seborrheic dermatitis has been reported after topical horsetail application.

Uva ursi is generally well tolerated at low doses short-term but can be toxic in high doses or with prolonged use; common side effects are diarrhea, nausea, stomach upset, and vomiting, and very high doses (30 grams or more) may be fatal. Cranberry appears well tolerated and is likely safe in normal food amounts; common side effects are diarrhea and gastrointestinal discomfort.

Concentrated cranberry supplements have not been well studied at high doses. During pregnancy, horsetail and uva ursi lack sufficient safety data and should be avoided; cranberry is rated likely safe.

During breastfeeding, there is not enough information for horsetail or uva ursi, so both should be avoided. Cranberry safety information during breastfeeding is not on file.

Side effects, ingredient by ingredient Horsetail Uva Ursi Cranberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Uva Ursi, Horsetail, Cranberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 998 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Renalplex, confirm with your own doctor or pharmacist if you use any of the following: antidiabetes medications (risk of low blood sugar), diuretics or lithium (risk of potassium loss or lithium buildup), HIV medications including efavirenz, blood thinners like warfarin, cholesterol drugs like atorvastatin, blood pressure medications like nifedipine, or pain relievers like diclofenac. These represent the main medication types documented to interact with this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Renalplex 750 mg combines three herbs used traditionally for urinary and kidney health, but their effectiveness for these purposes is not well established. If you take any medication—especially antidiabetes drugs, diuretics, lithium, HIV medications, cholesterol or blood pressure drugs, blood thinners, or pain relievers—you should check your exact medication list with your own doctor or pharmacist before starting this product, because the interaction risks are significant and widespread.

This is not a substitute for medical treatment of infections or kidney disease. Pregnant or breastfeeding individuals should talk with their doctor or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Renalplex 750 mg, straight from the product label.

Brand Sunshine Naturals
Barcode (UPC) 789939101353
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 49818
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Renalplex 750 mg by Sunshine Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
45
UPC/BARCODE
789939101353
IngredientAmount% DV
Proprietary Herbal Blend750 mg--
Horsetail0 NP--
Uva Ursi0 NP--
Cranberry0 NP--

Other ingredients: Rice Flour, Magnesium Stearate, Gelatin Caps

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Horsetail: The Commission E in Germany (similar to US FDA) approved the use of this plant as a natural help for infections of the urinary tract and kidney and bladder stones. Uva Ursi: Also approved the the Commission E as a help for inflammatory disorders of the urinary tract and infections. Cranberry: Helps protect the urinary tract by inhibiting bacteria from sticking to the walls of the bladder.

Made in U.S.A.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

This product does not contain sugar, starch , salt, or preservatives.

Precautions

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Formula

Horetail ~Uva Ursi ~Cranberry

Suggested/Recommended/Usage/Directions

Directions: Adults take two to 4 capsules daily with an 8oz. glass of water every time.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Renalplex 750 mg by Sunshine Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Renalplex 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Renalplex 750 mg by Sunshine Naturals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Herbal Blend

750 mg per serving

Other (inactive) ingredients: Rice Flour, Magnesium Stearate, Gelatin Caps. These complete the product’s ingredient list but are not active constituents.

Interaction report

Renalplex 750 mg by Sunshine Naturals Drug Interactions

Want to check YOUR meds against Renalplex 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
997Drugs
903 Moderate 94 Minor

Ingredients driving the most interactions

Uva Ursi 803
Cranberry 712
Horsetail 188

Individual Drug Interactions

The ingredients in Renalplex 750 mg interact with 997 drugs. Click any drug to see the details.

3 of the 3 ingredients in Renalplex 750 mg interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi Cranberry Horsetail

Each ingredient & the kinds of drugs it affects

For each ingredient in Renalplex 750 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi full monograph & interactions

Cranberry6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Cranberry full monograph & interactions

Horsetail5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Renalplex 750 mg, from the product label.

Sunshine Naturals

See all Sunshine Naturals products
Name
American Naturavit Inc.
City
Miami
State
FL
ZipCode
33166
Pharmacist Counseling Corner

Renalplex 750 mg by Sunshine Naturals: Common Questions

Does Renalplex 750 mg by Sunshine Naturals interact with any medications?
Yes. Based on its ingredients, Renalplex 750 mg has a known interaction with 997 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Renalplex 750 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Renalplex if I'm pregnant or breastfeeding?
Horsetail and uva ursi lack enough safety data and should be avoided during pregnancy and breastfeeding. Cranberry is rated likely safe during pregnancy, but breastfeeding safety is unclear. Talk with your doctor or pharmacist before using this product if you are pregnant or nursing.
What are the most common side effects?
The most common side effects are gastrointestinal: abdominal bloating, increased bowel movements, nausea, diarrhea, stomach upset, and vomiting. These are generally mild and occur with short-term use.
Does horsetail in this product have thiaminase?
Crude horsetail can contain thiaminase, which causes thiamine deficiency with prolonged use. However, Canadian horsetail products are required to be certified free of thiaminase-like activity. The label will tell you the source of your horsetail.
Does this product actually work for UTIs?
Cranberry is rated possibly effective for UTIs, but horsetail and uva ursi do not have reliable evidence supporting them for this purpose. This product is not a substitute for medical treatment of infections—talk to your doctor if you have a UTI.
Is this safe to take long-term?
Horsetail and uva ursi are not recommended for long-term use; both carry real risks with prolonged consumption. Cranberry supplements in concentrated form have not been well studied long-term. Discuss duration of use with your doctor or pharmacist.
What is uva ursi supposed to do?
Uva ursi has traditionally been used for urinary tract and prostate health. However, we have insufficient evidence to rate its effectiveness for these uses, and it has not been proven to work for urinary tract infections.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Renalplex 750 mg label
Go deeper

The Full Monographs Behind Renalplex 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph →
Sources

Sources & How We Checked

Renalplex 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horsetail 14 references
  1. Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
  2. Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
  3. Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
  4. Revilla MC, Andrade-Cetto A, Islas S, Wiedenfeld H. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. J Ethnopharmacol 2002;81:117-20. PubMed
  5. Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol.Nefrol.(Mosk) 1983;3(1):47-50.
  6. Henderson JA, Evans EV, and McIntosh RA. The antithiamine action of Equisetum. J Amer Vet Med Assoc 1952;120:375-378.
  7. Carneiro DM, Freire RC, Honório TC, Zoghaib I, Cardoso FF, Tresvenzol LM, de Paula JR, Sousa AL, Jardim PC, da Cunha LC. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Voluntee
  8. Klnçalp S, Ekiz F, Basar Ö, Coban S, Yüksel O. Equisetum arvense (Field Horsetail)-induced liver injury. Eur J Gastroenterol Hepatol. 2012 Feb;24(2):213-4. PubMed
  9. Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E, Claudio L. Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep. 2011 M PubMed
  10. Cordova E, Morganti L, Rodriguez C. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail (Equisetum arvense) and Antiretroviral Drugs. J Int Assoc Provid AIDS Care. 2017;16(1):11-13.
  11. García Gavilán MD, Moreno García AM, Rosales Zabal JM, Navarro Jarabo JM, Sánchez Cantos A. Case of drug-induced acute pancreatitis produced by horsetail infusions. Rev Esp Enferm Dig. 2017 Apr;109(4):301-304. PubMed
  12. Vieira GT, de Oliveira TT, Carneiro MAA, et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. PubMed
  13. Health Canada. Organism-Equisetum arvense. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq.do?id=6117&lang=eng. Accessed 21-July 2021.
  14. Bates D, Duong TB, Kheyson S, Moore K. Hyponatremia Secondary to Decreased Oral Intake and SIADH and Possibly Exacerbated by Horsetail (Equisetum arvense). Can J Hosp Pharm 2021;74(4):386-389. PubMed

See these in context on the Horsetail monograph →

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
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See these in context on the Uva Ursi monograph →

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See these in context on the Cranberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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