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Dietary supplement

Sarsaparilla Root Ingredients & Drug Interactions

by Botanic Choice

Sarsaparilla Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla Root is a dietary supplement by Botanic Choice with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla Root by Botanic Choice

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla Root by Botanic Choice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sarsaparilla Root by Botanic Choice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: sarsaparilla extract, a botanical preparation derived from the sarsaparilla plant root. The liquid also contains glycerin and water as inactive ingredients to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sarsaparilla product and its label doesn't state a use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish sarsaparilla's effectiveness for cancer, psoriasis, or rheumatoid arthritis. In each case, there is insufficient reliable evidence to rate how well it works.

If you're considering it for one of these conditions, talk with your doctor about what the research actually supports.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla is likely low-risk when used in food amounts, but human safety data for supplement doses are limited. Occupational exposure to sarsaparilla root dust can trigger rhinitis (nasal inflammation) and asthma symptoms, though this is mainly a concern for workers handling the raw material.

There isn't enough safety information to recommend this product during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in these situations.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Sarsaparilla Root, check with your doctor or pharmacist if you take lithium or digoxin (Lanoxin). The product's diuretic properties may reduce lithium excretion and raise its levels, and may increase digoxin-related cardiac toxicity risk through potassium loss.

These are Moderate-severity interactions that could affect how your medication works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sarsaparilla Root by Botanic Choice may appeal to those interested in traditional herbal supplements, but the evidence for its effectiveness isn't established in our data. More importantly, if you take lithium or digoxin, you need to check with your own doctor or pharmacist before using it — the diuretic effects could affect how these medications work.

Pregnancy and breastfeeding safety data are also limited, so discuss this with your healthcare provider if those apply.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla Root, straight from the product label.

Brand Botanic Choice
Barcode (UPC) 703308200225
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 199523
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla Root by Botanic Choice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
UPC/BARCODE
703308200225
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Sarsaparilla extract59 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

General Statements

Trusted since 1910 3:1 extract

Formulation

Alcohol free liquid extract

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 mL (approx. 28 drops) three times daily, in a small amount of water.

Shake well.

Precautions

Warning: If you are taking any medications or are pregnant or nursing do not use prior to consulting a physician.

Use only if seal is unbroken.

Keep out of reach of children

Storage

Best if used by date on bottle. Store in a dry, cool place.

Brand IP Statement(s)

IBG Indiana Botanic Gardens

General

C-104664

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla Root by Botanic Choice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla Root by Botanic Choice

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Amounts shown are per serving.

Sarsaparilla extract

Interacts with
2 drugs
59 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sarsaparilla Root by Botanic Choice Drug Interactions

Want to check YOUR meds against Sarsaparilla Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla extract 2

Individual Drug Interactions

The ingredients in Sarsaparilla Root interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla Root interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla Root, from the product label.

Botanic Choice

See all Botanic Choice products
Name
Indiana Botanic Gardens, Inc.
Street Address
3401 W. 37th Ave.
City
Hobart
State
IN
ZipCode
46342
Phone Number
1-800-644-8327
Web Address
www.botanicchoice.com
Pharmacist Counseling Corner

Sarsaparilla Root by Botanic Choice: Common Questions

Does Sarsaparilla Root by Botanic Choice interact with any medications?
Yes. Based on its ingredients, Sarsaparilla Root has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
There isn't enough safety information to know whether sarsaparilla is safe in pregnancy. Talk with your doctor or pharmacist before taking it.
Is it safe to breastfeed while taking this product?
Not enough safety data exist for breastfeeding use. Discuss this with your doctor or pharmacist to decide what's best for you and your baby.
Does sarsaparilla actually work for arthritis or psoriasis?
The evidence we hold doesn't establish that it works for rheumatoid arthritis or psoriasis — there's insufficient reliable evidence to rate. If you're interested in it for one of these conditions, talk with your doctor about treatments with stronger evidence.
What are the side effects?
Occupational exposure to sarsaparilla root dust can cause nasal inflammation and asthma symptoms, though that's mainly a concern for workers handling the raw material. Human safety data for supplement doses are limited, so unexpected effects could occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla Root is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla Root label
Go deeper

The Full Monographs Behind Sarsaparilla Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Sarsaparilla Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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