No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Seriphos Ingredients & Drug Interactions

by InterPlexus

Capsule Category: Other Combinations
No known interaction
The interaction bottom line No known interaction

Seriphos is a dietary supplement by InterPlexus with 2 active ingredients. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Seriphos by InterPlexus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Seriphos contains 2 active ingredients delivered in a proprietary blend: phosphorylated serine and ethanolamine phosphate. Phosphorylated serine is a modified form of the amino acid serine; ethanolamine phosphate is a phospholipid compound.

The product also contains inactive ingredients — magnesium stearate, cellulose, hypromellose, and water — used to form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Adaptogen and adrenal support.
  • We looked for evidence on: stress response, cortisol regulation, adrenal fatigue, HPA axis function.
  • The closest evidence on file: Serine is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).

The evidence for phosphorylated serine is mixed and incomplete. It's rated possibly effective for schizophrenia, but for Alzheimer's disease, ALS, back pain, PTSD, and cognitive function, there isn't enough reliable evidence to rate it.

That doesn't mean it doesn't work for those uses — it means the studies either aren't there yet or aren't conclusive enough to say.

The evidence, ingredient by ingredient Serine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphorylated serine is generally well tolerated in the doses studied, though long-term safety isn't firmly established. The most common side effects are gastrointestinal — abdominal pain, bloating, indigestion, loss of appetite, and nausea — and they tend to be dose-dependent.

Seizures are rare but have been reported at very high doses of L-serine. There isn't enough safety data on serine supplements in pregnancy, so the evidence advises against it unless your doctor says otherwise.

Safety during breastfeeding hasn't been studied; avoid it unless your doctor directs you to use it.

Side effects, ingredient by ingredient Serine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, we were unable to evaluate ethanolamine phosphate, so check your specific medications with your doctor or pharmacist before starting.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

Seriphos may be worth considering if you're exploring serine for schizophrenia, though the evidence is modest. If you're thinking about it for cognitive function, PTSD, or neurological conditions like ALS, the evidence isn't there yet to say whether it'll help.

Before you start, talk it over with your doctor or pharmacist — especially if you're pregnant, breastfeeding, or take any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Seriphos, straight from the product label.

Brand InterPlexus
Barcode (UPC) 766897258510
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306838
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Seriphos by InterPlexus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
100
UPC/BARCODE
766897258510
IngredientAmount% DV
Proprietary Blend1000 mg--
Ethanolamine Phosphate0 NP--
Phosphorylated Serine0 NP--

Other ingredients: Magnesium Stearate, Cellulose, Hypromellose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily with water 15 minutes before a meal or as directed by your physician.

Precautions

Caution: If pregnant or nursing, consult your physician before using this or any other product.

Keep out of reach of children.

Allergen Information: Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place.

Formulation

Manufactured in the USA in a GMP compliant facility.

Original formula Adaptogen and adrenal support

Non-GMO

Vegetarian Suitable for vegetarians

Allergen Information: Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Dairy, soy, egg & gluten free.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Facebook Instagram LinkedIn Twitter Let's connect on social media @Interplexus

Formula

Phosphorylated serine

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Copyright 2021 Interplexus, Inc.

See for yourself

Seriphos by InterPlexus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Seriphos by InterPlexus

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1000 mg per serving

Other (inactive) ingredients: Magnesium Stearate, Cellulose, Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Seriphos by InterPlexus Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Seriphos. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Seriphos, from the product label.

InterPlexus

See all InterPlexus products
Name
InterPlexus, Inc.
Street Address
840 S. 333rd St.
City
Federal Way
State
WA
ZipCode
98003
Phone Number
1-800-875-0511
Web Address
interplexus.com
Pharmacist Counseling Corner

Seriphos by InterPlexus: Common Questions

Does Seriphos by InterPlexus interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Seriphos. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Seriphos contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphorylated serine, and what's it supposed to do?
Phosphorylated serine is a modified form of serine, an amino acid your body makes. It's studied mainly for schizophrenia — where the evidence suggests it might help — but research for other uses like memory, PTSD, or ALS is too limited to say whether it works.
Will this upset my stomach?
Gastrointestinal side effects — bloating, nausea, indigestion, belly pain, and appetite loss — are the most common complaints, and they tend to happen more at higher doses. Most people who do experience them find them mild, but start low and see how you feel.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data on serine supplements in pregnancy, so it's best avoided unless your doctor advises otherwise. Safety during breastfeeding hasn't been studied either — talk with your doctor or pharmacist to see if it's right for you.
What are the inactive ingredients?
The capsule contains magnesium stearate, cellulose, hypromellose, and water — standard excipients that help form and preserve the product.
Can I take this long-term?
The safety data we have covers shorter-term use in studies. Long-term safety isn't well established, so talk with your doctor or pharmacist if you're thinking about taking it regularly for months or longer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Seriphos is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Seriphos label
Go deeper

The Full Monographs Behind Seriphos’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Seriphos's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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