No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Sibb-Zymes Ingredients & Drug Interactions

by Klaire Labs

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Sibb-Zymes is a dietary supplement by Klaire Labs with 5 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Sibb-Zymes by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Enzyme Blend” is a proprietary blend — the label gives one combined amount (612 mg) without saying how much of each component you get.
  • “Protease/Peptidase Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

Sibb-Zymes is a capsule containing seven active digestive enzymes designed to help break down food. Lactase breaks down milk sugar (lactose); Glucoamylase, Maltase, and Sucrase handle different carbohydrates; Dipeptidyl Peptidase-IV, Protease/Peptidase Complex, Endopeptidase, and Exopeptidase work together to break down proteins into smaller pieces your body can absorb.

The capsule itself is made from hydroxypropylmethylcellulose (a plant-based material), water, and cellulose.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Enzyme supplement for lactose digestion.
  • We looked for evidence on: Lactose intolerance, Lactose malabsorption, Postprandial bloating.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).

Lactase is effective for lactose intolerance—the condition where you can't digest milk sugar well. For the other digestive enzymes in this product—Glucoamylase, Maltase, Sucrase, Dipeptidyl Peptidase-IV, and the protease complex—we don't hold effectiveness data in our system.

The evidence base for enzyme blends used to support general digestion has not been assessed here.

The evidence, ingredient by ingredient Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when used as directed. Rarely, some people may develop an allergic reaction to lactase itself (contact dermatitis or allergic rhinoconjunctivitis have been reported in workers exposed to powdered lactase).

For the other ingredients in this product, we hold no formal safety or adverse-effect data. During pregnancy and while nursing, lactase is rated likely safe; however, the safety data for the other enzymes in this product isn't on file.

Talk with your doctor or pharmacist about whether Sibb-Zymes is right for you during pregnancy or lactation.

Side effects, ingredient by ingredient Lactase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, we hold no interaction data for six of the seven active ingredients—Glucoamylase, Maltase, Dipeptidyl Peptidase-IV, Sucrase, Endopeptidase, and Exopeptidase.

Before you take this product, use the medication search tool on this page to check your exact prescriptions and over-the-counter drugs.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Sibb-Zymes is a digestive enzyme blend best considered if you have trouble digesting milk sugar (lactose) or are looking for general digestive support. Because we could not check most of the enzymes in this product for drug interactions, check your medications before you start.

If you're pregnant, nursing, or have any digestive disorders, talk with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sibb-Zymes, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 790616310043
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 281213
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sibb-Zymes by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
790616310043
IngredientAmount% DV
Lactase0 NP--
Glucoamylase0 NP--
Maltase0 NP--
Enzyme Blend612 mg--
Dipeptidyl Peptidase-IV0 NP--
Sucrase0 NP--
Endopeptidase0 NP--
Exopeptidase0 NP--
Protease/Peptidase Complex0 NP--

Other ingredients: Hydroxypropylmethylcellulose, Water, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.

Units are those used in edition nine (IX) of the Food Chemicals Codex (FCC)

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested Use: 2 capsules at the beginning of each meal or as directed by a healthcare professional.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Enzyme Supplement

Brand IP Statement(s)

SFI

See for yourself

Sibb-Zymes by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sibb-Zymes by Klaire Labs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enzyme Blend

612 mg per serving
  • Lactase
  • › Glucoamylase
  • › Maltase
  • › Sucrase
  • › Protease/Peptidase Complex

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Water, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sibb-Zymes by Klaire Labs Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Sibb-Zymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Sibb-Zymes, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Sibb-Zymes by Klaire Labs: Common Questions

Does Sibb-Zymes by Klaire Labs interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Sibb-Zymes. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Sibb-Zymes contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lactase safe if I'm pregnant or nursing?
Lactase is rated likely safe in pregnancy and lactation. The other enzymes in this product don't have pregnancy or nursing data on file, so check with your doctor or pharmacist to make sure Sibb-Zymes is appropriate for you right now.
What is lactase, and what does it do?
Lactase is an enzyme that breaks down lactose—the natural sugar found in milk and dairy products. If you have lactose intolerance (trouble digesting milk sugar), lactase can help.
Does lactase actually work for lactose intolerance?
Yes. Lactase is rated effective for lactose intolerance. The evidence for the other digestive enzymes in this product isn't established in the data we hold.
Can I be allergic to lactase itself?
It's rare, but yes. A small number of people—mainly workers exposed to powdered lactase over time—have developed allergic reactions like contact dermatitis or allergic rhinoconjunctivitis. If you notice itching, swelling, or respiratory symptoms after taking this product, stop and talk to your doctor.
What are the inactive ingredients in this product?
The capsule contains hydroxypropylmethylcellulose (a plant-based material), water, and cellulose. There are no other additives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sibb-Zymes is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sibb-Zymes label
Go deeper

The Full Monographs Behind Sibb-Zymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Sibb-Zymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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