No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Skn-gen Ingredients & Drug Interactions

by Genestra Brands

Liquid Category: Botanical
No known interaction
The interaction bottom line No known interaction

Skn-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol health, brain health, general nutrition (omega-3 source).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Skn-gen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Skn-gen is a liquid formula with 3 active herbal ingredients: Elm bud extract, English Walnut bud extract, and Cedar of Lebanon young shoot extract. These are plant tissue extracts — early bud or shoot material from these trees.

The product also contains purified water, ethanol, and glycerin as inactive ingredients (the base that holds the active extracts).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded English Walnut's overall clinical evidence instead.

Moderate

Some clinical evidence supports English Walnut for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

English Walnut extract is possibly effective for high cholesterol. For heart disease and diabetes, the evidence isn't strong enough to rate.

The effectiveness data we hold doesn't cover Elm or Cedar of Lebanon, so we can't speak to what those ingredients may do.

The evidence, ingredient by ingredient English Walnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

English Walnut extract from the nut itself is generally well tolerated, though it can soften stools and cause mild bloating. People with tree nut allergies need to be cautious — walnuts can trigger serious allergic reactions, and oral allergy syndrome (itching in the mouth, and rarely swelling of the lips and tongue) may occur.

Walnut leaf extract has been reported to cause mild diarrhea in a meaningful number of users. The safety of concentrated walnut leaf or husk extracts and the safety of concentrated supplements overall hasn't been well studied.

No pregnancy or breastfeeding data is on file for Elm or Cedar of Lebanon; for English Walnut, the evidence is mixed (possibly unsafe in lactation, likely safe in pregnancy), so discuss with your doctor or pharmacist before using during either.

Side effects, ingredient by ingredient English Walnut

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That said, because we have no interaction data for Elm bud or Cedar of Lebanon, ask your pharmacist or doctor to verify this product won't interfere with your specific medications before you take it.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

Skn-gen is a herbal extract blend marketed for skin health. If you have tree nut allergies or a history of oral allergy syndrome, this product isn't a fit because of the walnut content.

If you take medications, check them against our tool on this page, or confirm with your doctor or pharmacist before starting. Pregnant or nursing?

Talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skn-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319611651
Net contents 0.5 fl. Oz.; 15 mL
Market status Off market
Date entered into DSLD Sep 22, 2016
DSLD ID 64830
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skn-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
88319611651
IngredientAmount% DV
Elm (Ulmus campestris) bud extract0.09 mL--
English Walnut (Juglans regia) bud extract0.09 mL--
Cedar of Lebanon (Cedrus libani) young shoot extract0.09 mL--

Other ingredients: purified Water, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Adults and Children (over 12 years): Take 10 drops once daily, or as recommended by your healthcare practitioner. Invert bottle to 45(0) and shake lightly allowing drops to fall directly into mouth or in 1/4 oz. of water.

Precautions

For risk information, see outer box. Do not use if seal is missing or broken.

Risk Information: If you are pregnant or breastfeeding do not use, unless directed by your healthcare practitioner.

If symptoms persist or worsen consult your healthcare practitioner.

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if inner seal is missing or broken.

General

933

FDA Statement of Identity

Herbal Supplement

General Statements

Phyto-Gen

Formula

- English Walnut - Elm - Cedar of Lebanon

Formulation

Guaranteed to contain no added starch, yeast, corn, soy, sodium, sugar, artificial coloring or flavoring, antimicrobial preservatives, dairy or animal products.

Ideal for vegans.

Storage

Store in a cool, dry place.

See for yourself

Skn-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Skn-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Elm (Ulmus campestris) bud extract

0.09 mL per serving
0.09 mL per serving

English walnut is a nutritious tree nut rich in plant-based omega-3 fats, fiber, and antioxidants, and eating it as part of a balanced diet may suppor...

English Walnut (Juglans regia) bud extract monograph & interactions

Cedar of Lebanon (Cedrus libani) young shoot extract

0.09 mL per serving

Other (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skn-gen by Genestra Brands Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Skn-gen. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Skn-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Skn-gen by Genestra Brands: Common Questions

Does Skn-gen by Genestra Brands interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Skn-gen. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Skn-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have a tree nut allergy?
No — this product contains English Walnut extract, and tree nuts can cause serious allergic reactions in sensitive people. Even if you've tolerated walnuts as food, a concentrated supplement might behave differently. If you have any tree nut allergy, skip this product and talk to your doctor about alternatives.
Will it upset my stomach?
English Walnut extract can soften stools and cause mild bloating, and walnut leaf extracts have been reported to cause mild diarrhea — in one study, about 39% of users experienced this. If your stomach is sensitive, start low and see how you feel, or run it by your pharmacist first.
Is it safe to take while breastfeeding?
The data suggests English Walnut extract might not be safe in lactation. We have no safety data on the other two ingredients. Talk with your doctor or pharmacist before taking this product while breastfeeding — they can help you decide if it's right for you.
Is it safe in pregnancy?
English Walnut extract is rated likely safe in pregnancy, but we have no pregnancy safety data for Elm or Cedar of Lebanon. Discuss this with your doctor before taking it during pregnancy so you can make an informed decision together.
Does it actually work for skin?
The effectiveness data we hold covers English Walnut for cholesterol and heart health, not skin. We don't have evidence on file for what Elm or Cedar of Lebanon do, so we can't tell you whether this formula works for skin concerns.
What are these plant extracts, and why are they in the product?
They're extracts from the early buds or shoots of Elm, English Walnut, and Cedar of Lebanon trees — concentrated plant tissue. The product is formulated around these botanicals, though the specific reason each was chosen isn't detailed in the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skn-gen is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skn-gen label
Sources

Sources & How We Checked

Skn-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

English Walnut 16 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  4. Zambon D, Sabate J, Munoz S, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med 2000;132:538-46. PubMed
  5. Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6. PubMed
  6. Sabate J, Fraser GE, Burke K, et al. Effects of walnuts on serum lipid levels and blood pressure in normal men. N Engl J Med 1993;328:603-7. PubMed
  7. Feldman EB. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr 2002;132:1062S-101S. PubMed
  8. Asero R. Detection and clinical characterization of patients with oral allergy syndrome caused by stable allergens in Rosaceae and nuts. Ann Allergy Asthma Immunol 1999;83:377-83. PubMed
  9. Bonamonte D, Foti C, Angelini G. Hyperpigmentation and contact dermatitis due to Juglans regia. Contact Dermatitis 2001;44:101-2. PubMed
  10. Hu FB, Stampfer MJ. Nut consumption and risk of coronary heart disease: a review of epidemiologic evidence. Curr Atheroscler Rep 1999;1:204-9. PubMed
  11. Tapsell LC, Gillen LJ, Patch CS, et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 2004;27:2777-83. PubMed
  12. Rabiei K, Ebrahimzadeh MA, Saeedi M, et al. Effects of a hydroalcoholic extract of Juglans regia (walnut) leaves on blood glucose and major cardiovascular risk factors in type 2 diabetic patients: a double-blind, placebo-controlled clinical trial. BMC Com PubMed
  13. Hosseini S, Jamshidi L, Mehrzadi S, et al. Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. J Ethnopharmacol. 2014;152(3):451-6. PubMed
  14. FDA. Qualified Health Claims: Letter of Enforcement Discretion - Walnuts and Coronary Heart Disease (Docket No 02P-0292). March 2004. Available at: http://wayback.archive-it.org/7993/20171114183649/https:/www.fda.gov/Food/IngredientsPackagingLabeling/Labe
  15. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
  16. Mirzababaei A, Daneshvar M, Abaj F, et al. The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Clin Nutr Re

See these in context on the English Walnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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