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Dietary supplement

Slippery Elm 400 mg Ingredients & Drug Interactions

by NOW

Slippery Elm 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Slippery Elm 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Slippery Elm 400 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Slippery Elm 400 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Slippery Elm 400 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Slippery Elm 400 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: slippery elm inner bark at 400 mg per capsule. Slippery elm is a tree bark traditionally used to soothe the digestive tract and throat.

The capsule also holds inactive ingredients — hypromellose, stearic acid, and microcrystalline cellulose — which are common binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Slippery Elm product and its label doesn't state a use — see Slippery Elm's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for slippery elm isn't established in our data. We don't hold reliable evidence to rate it for cancer, constipation, cough, inflammatory bowel disease, or diarrhea.

That doesn't mean it doesn't work — it means the studies we have access to aren't robust enough to make a clear claim. If you're considering slippery elm for one of those reasons, talk with your doctor about what the research actually shows and whether it's right for you.

The evidence, ingredient by ingredient Slippery Elm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Slippery elm is generally well tolerated for short-term use, though high-quality safety data are limited. The main concern is contact dermatitis (skin irritation) from topical exposure; the pollen and oleoresin in the bark can also trigger allergic reactions like hives.

During pregnancy, there isn't enough reliable safety data — some sources advise caution. While breastfeeding, safety information is too sparse to know either way.

If you're pregnant or nursing, talk with your pharmacist or doctor before starting slippery elm.

Side effects, ingredient by ingredient Slippery Elm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check any oral medications you take — slippery elm may slow their absorption and reduce how well they work. Because the interaction can affect a large number of drugs, use the medication checker on this page with your complete list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Slippery elm is a traditional digestive remedy, but we don't yet have solid evidence it works for the conditions people use it for. Its main concern is that it may slow how your body absorbs other oral medications — a Moderate interaction risk.

Always check your exact medications before you start, and space out doses if you can.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Slippery Elm 400 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047502
Net contents 100 Veg Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 314077
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Slippery Elm 400 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
50
UPC/BARCODE
733739047502
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Slippery Elm800 mg--

Other ingredients: Hypromellose, Stearic Acid, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 2 capsules 1 to 3 times daily.

Formula

Slippery elm, also known as red elm, moose elm or Indian elm, is a small tree that has been traditionally used by herbalists for over 100 years. It was reportedly used by native North Americans and early settlers as a survival food. Its bark is known for its mucilage constituents, which can help to coat and soothe the tissues of the GI tract.

Triangle K (Kosher)

FDA Disclaimer Statement

These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Pregnant or nursing women: do not use unless recommended by your physician. Consult physician if taking medication or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Helps Coat and Soothe GI Tract

Non-GMO

Vegetarian/Vegan

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish, tree nut or sesame ingredients.

FDA Statement of Identity

Herbal Supplement

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

Storage

Store in a cool, dry place after opening.

General Statements

Botanicals/Herbs Family owned since 1968.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Slippery Elm 400 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Slippery Elm 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Slippery Elm 400 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Slippery Elm

Interacts with
2,022 drugs
800 mg per serving

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...

Slippery Elm monograph & interactions

Other (inactive) ingredients: Hypromellose, Stearic Acid, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Slippery Elm 400 mg by NOW Drug Interactions

Want to check YOUR meds against Slippery Elm 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Slippery Elm 2,022

Individual Drug Interactions

The ingredients in Slippery Elm 400 mg interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in Slippery Elm 400 mg interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm

Each ingredient & the kinds of drugs it affects

For each ingredient in Slippery Elm 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Slippery Elm 400 mg, from the product label.

NOW

See all NOW products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Slippery Elm 400 mg by NOW: Common Questions

Does Slippery Elm 400 mg by NOW interact with any medications?
Yes. Based on its ingredients, Slippery Elm 400 mg has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Slippery Elm 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take slippery elm while I'm pregnant?
There isn't enough reliable safety data during pregnancy. Some sources advise caution. Talk with your pharmacist or doctor for personalized advice before starting it.
What is slippery elm used for?
It's traditionally used to soothe the digestive tract and throat. The evidence we hold isn't strong enough to rate it for constipation, diarrhea, inflammatory bowel disease, cough, or cancer.
Does slippery elm have any side effects?
It's generally well tolerated for short-term use. Contact with the skin can cause irritation or hives, and the pollen is an allergen. Long-term safety data are limited.
Can I breastfeed while taking slippery elm?
There's too little information on safety while breastfeeding to know either way. Check with your pharmacist or doctor before starting it.
How does slippery elm interact with medications?
The mucilage in slippery elm coats your digestive tract and may slow the absorption of oral drugs, which can lower how much of the medication reaches your bloodstream. Spacing doses apart a couple of hours apart may help — ask your pharmacist about timing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Slippery Elm 400 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Slippery Elm 400 mg label
Go deeper

The Full Monographs Behind Slippery Elm 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph →
Sources

Sources & How We Checked

Slippery Elm 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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