SpectraZyme Pan 9x ES Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking SpectraZyme Pan 9x ES against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SpectraZyme Pan 9x ES is a dietary supplement by Metagenics with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of SpectraZyme Pan 9x ES by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
SpectraZyme Pan 9x ES contains 3 active ingredients: amylase, protease, and lipase — all digestive enzymes that break down carbohydrates, proteins, and fats in food. These come from a pancreatin enzyme blend, which includes porcine (pig) pancreatic concentrate.
The tablet also contains several inactive ingredients such as microcrystalline cellulose, croscarmellose sodium, and silica to hold it together.
Does it work?
No specific claim
The evidence for these enzymes is limited. For lipase specifically, the data we hold shows insufficient reliable evidence to rate its effectiveness for inflammatory bowel disease, dyspepsia (indigestion), or prematurity.
Effectiveness ratings for amylase and protease are not established in our data.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated in adults, though some people report mild digestive upset or allergic reactions. Protease can rarely trigger allergic responses — occupational exposure to related airborne enzymes has caused allergic rhinitis or asthma in some cases.
For lipase, no adverse effects have been reported in adults at typical doses, but a thorough safety review hasn't been done. During pregnancy, protease safety has not been established and is best avoided unless prescribed by your doctor.
Lipase safety in pregnancy is unclear — use only if your doctor advises it. While breastfeeding, neither protease nor lipase has much safety data — talk with your healthcare provider before using either.
We hold no safety data for amylase.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we cannot verify amylase — if you take any medications, use the search tool on this page to check your exact drugs before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. No medication interactions are currently documented, and safety information is well characterized.
SpectraZyme Pan 9x ES is a digestive enzyme blend that may help some people break down food, though strong evidence for its specific uses is limited. It's generally well tolerated by adults, but if you're pregnant, breastfeeding, or have a serious digestive condition, talk it over with your doctor or pharmacist before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SpectraZyme Pan 9x ES, straight from the product label.
| Brand | Metagenics |
|---|---|
| Net contents | 90 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 19, 2022 |
| DSLD ID | 266571 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SpectraZyme Pan 9x ES by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Pancreatin Enzyme Blend | 348 mg | -- |
Other ingredients: Porcine Pancreatic concentrate, Microcrystalline Cellulose, Croscarmellose Sodium, Sodium Starch Glycolate, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
SpectraZyme Pan 9x ES is a comprehensive enzyme complex that provides support for digestive function. Provides twice the digestive enzyme strength of regular Pan 9x.
This product is non-GMO and gluten-free.
Bioactive pancreatic enzymes for digestive support
Formula
The porcine pancreatic concentrate is processed under special conditions so that the delicate enzyme constituents remain intact.
Suggested/Recommended/Usage/Directions
Directions: Take one tablet with each meal or as directed by your health care practitioner.
Precautions
Caution: Do not use if there is a prior history of or a current peptic or duodenal ulcer.
Do not use in individuals who have a known allergy or hypersensitivity to pork protein.
Consult your healthcare practitioner if taking other nutritional supplements or medications.
Keep out of the reach of children.
Practitioner exclusive
Seals/Symbols
GF Certified Gluten-free
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SpectraZyme Pan 9x ES by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SpectraZyme Pan 9x ES by Metagenics
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Porcine Pancreatic concentrate, Microcrystalline Cellulose, Croscarmellose Sodium, Sodium Starch Glycolate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
SpectraZyme Pan 9x ES by Metagenics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in SpectraZyme Pan 9x ES. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for SpectraZyme Pan 9x ES, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Gig Harbor
- State
- WA
- ZipCode
- 98332
- Phone Number
- 800 692 9400
- Web Address
- metagenics.com
SpectraZyme Pan 9x ES by Metagenics: Common Questions
Does SpectraZyme Pan 9x ES by Metagenics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What's in this product, and where do these enzymes come from?
Is it safe to take while pregnant?
Is it safe while breastfeeding?
Can this product cause side effects?
Does this product actually work for digestion?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SpectraZyme Pan 9x ES is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SpectraZyme Pan 9x ES’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
SpectraZyme Pan 9x ES's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC