Squalene Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Squalene against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Squalene is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for immune support, skin conditions and wound healing, cancer support (unproven).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Squalene by Cardiovascular Research
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: squalene, a naturally occurring compound sourced from shark liver oil. The softgel capsule also contains gelatin, glycerin, and purified water as inactive ingredients to hold and deliver the squalene.
Does it work?
Not established
We don't have established evidence for squalene's effectiveness. The data we hold rates its use for cancer, cold, influenza, chemotherapy-related low white blood cells (chemotherapy-induced leukopenia), and radiation-induced nausea as having insufficient reliable evidence.
In plain terms: we can't say whether it works for any of these uses based on the science available to us.
How safe is it?
Well-documented data
Squalene is generally well tolerated over the short term, but human safety data are limited and product quality varies. One case of severe liver inflammation (hepatitis) has been reported after daily use for two weeks, and higher doses (15 grams daily) have raised total cholesterol and lowered HDL cholesterol in healthy adults — changes that reversed after stopping the product.
There's also a risk of aspiration and lipoid pneumonia (a lung condition from oil inhalation). The safety data advise against use during pregnancy and while breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check. That said, always confirm your exact medications on this page — the absence of documented interactions isn't a guarantee none exist.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Squalene carries limited safety evidence and no established effectiveness for the conditions it's marketed for. If you're pregnant, nursing, or have liver concerns or a history of aspiration, this isn't the right choice.
Talk to your pharmacist about whether this fits your health picture before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Squalene, straight from the product label.
| Brand | Cardiovascular Research |
|---|---|
| Barcode (UPC) | 787790945987 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 283463 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Squalene by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Fat | 1 Gram(s) | 1% |
| Calories | 10 Calorie(s) | -- |
| Squalene | 1000 mg | -- |
Other ingredients: Gelatin, Glycerin, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Formula
Squalene from shark liver oil is extracted from the shark speices, Sominosus microcephalus and Lamna nasus. The rich source of natural deep sea shark liver oil is standardized to contain alkylglycerols and contains no yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color or flavor.
Natural Deep Sea Shark Liver Oil
Formulation
The rich source of natural source of natural deep sea shark liver oil is standardized to contain alkylglycerols and contains no yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color or flavor.
Gluten free, Casein free
Suggested/Recommended/Usage/Directions
Directions Take one softgel, or more as directed by a physician.
Storage
Store in a cool dry place to ensure freshness.
General Statements
Ecological Formulas
Precautions
Contains: Fish
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Squalene by Cardiovascular Research label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Squalene by Cardiovascular Research
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Squalene
No knowninteractions
Shark liver oil is taken from the livers of deep-sea sharks and is rich in compounds called alkylglycerols and squalene. People use it for immune supp...
Squalene monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Squalene by Cardiovascular Research Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Squalene. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Squalene, from the product label.
Cardiovascular Research
See all Cardiovascular Research products- Name
- CARDIOVASCULAR RESEARCH LTD.
- Street Address
- 1061-B SHARY CIRCLE
- City
- CONCORD
- State
- CA
- ZipCode
- 94518
Squalene by Cardiovascular Research: Common Questions
Does Squalene by Cardiovascular Research interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take squalene if I'm pregnant or breastfeeding?
Does squalene really help with cancer or the common cold?
Are there any side effects I should know about?
What exactly is squalene?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Squalene is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Squalene’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Squalene's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Shark Liver Oil 6 references
- Lee JY, Lee KS, Kim TS, et al. Squalene-induced extrinsic lipoid pneumonia: serial radiologic findings in nine patients. J Comput Assist Tomogr 1999;23:730-5. PubMed
- Lee JS, Im JG, Song KS, et al. Exogenous lipoid pneumonia: high-resolution CT findings. Eur Radiol 1999;9:287-91. PubMed
- Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-7.
- Deniau AL, Mosset P, Pédrono F, Mitre R, Le Bot D, Legrand AB. Multiple beneficial health effects of natural alkylglycerols from shark liver oil. Mar Drugs. 2010 Jul 19;8(7):2175-84. PubMed
- Kilincalp S, Deveci M, Basar O, Ekiz F, Coban S, Yuksel O. Shark liver oil: hidden dangers. Ann Hepatol. 2012 Sep-Oct;11(5):728-30. DOI
- Hamadate N, Matsumoto Y, Seto K, Yamamoto T, Yamaguchi H, Nakagawa T, Yamamoto E, Fukagawa M, Yazawa K. Vascular effects and safety of supplementation with shark liver oil in middle-aged and elderly males. Exp Ther Med. 2015 Aug;10(2):641-646. Epub 2015 J PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC