Standardized Bilberry Fruit Extract Ingredients & Drug Interactions
by Bluebonnet
What is this page for?
First and foremost: checking Standardized Bilberry Fruit Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Standardized Bilberry Fruit Extract is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Standardized Bilberry Fruit Extract by Bluebonnet
Ask about any prescription or over-the-counter medication and we check it for interactions with Standardized Bilberry Fruit Extract by Bluebonnet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Standardized Bilberry Fruit Extract by Bluebonnet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bilberry fruit extract, a concentrated form of the bilberry plant. Bilberry is a dark blue berry traditionally used to support eye and circulatory health.
The capsule itself is made from vegetable-derived materials, with cellulose, magnesium stearate, and silica as inactive ingredients to hold everything together.
Does it work?
Leans against
The evidence for bilberry extract is mixed and incomplete. For night vision, the data suggests it's possibly ineffective — meaning claims about sharp eyesight in low light don't hold up well in research.
For age-related cognitive decline, age-related macular degeneration (AMD), atherosclerosis, high cholesterol (hyperlipidemia), and chronic venous insufficiency, there simply isn't enough reliable evidence to say whether it works. If you're considering this supplement for any of these reasons, talk with your doctor or pharmacist about what the science actually supports.
How safe is it?
Well-documented data
Bilberry fruit as a food is generally well tolerated and safe. The supplement form, however, has limited long-term safety data, and we'd advise caution with concentrated doses.
The most common side effects you might notice are dark-colored stools (or even dark discoloration of your tongue or teeth), flatulence, and mild stomach discomfort. In small studies, a small number of people reported temporary digestive upset, and in one study roughly one-third of participants experienced mild-to-moderate gas — though that group had ulcerative colitis and lacked a control group, so the finding is limited.
Overall, when people do take it, bilberry extract seems to cause mostly tolerable effects.
Meds to double-check
Moderate interaction found
Before taking this product, check whether you take any blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes medications, drugs metabolized by the CYP2E1 liver enzyme, or erlotinib. Bilberry extract may increase bleeding risk, lower your blood sugar further, or reduce how well these medications work.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you eat bilberries as food, that's fine. If you're thinking about taking this concentrated supplement, first check your medications against the interaction list below — especially if you take blood thinners, diabetes drugs, or cancer medications.
The evidence for what this supplement actually does is thin, and long-term safety data is limited. Talk with your pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Standardized Bilberry Fruit Extract, straight from the product label.
| Brand | Bluebonnet |
|---|---|
| Barcode (UPC) | 743715013131 |
| Net contents | 120 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2018 |
| DSLD ID | 179371 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Standardized Bilberry Fruit Extract by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bilberry fruit extract | 80 mg | -- |
Other ingredients: Kosher Vegetable Capsules, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one vegetarian capsule daily or as directed by a healthcare practitioner.
Formula
Bluebonnet’s Standardized Bilberry Fruit Extract Capsules contain Mirtoselect from Indena, a standardized extract of anthocyanins, the most researched active constituents found in bilberry fruit.
Bluebonnet’s KOF-K Certification #K-0000700
36% Anthocyanins
General Statements
A clean and gentle water-based extraction method is employed to capture and preserve bilberry’s most valuable components.
Sustainably Wildcrafted.
Formulation
Available in easy-to-swallow vegetable derived capsules for maximum assimilation/absorption and for a truly vegetarian/vegan formula.
Made with non GMO ingredients
Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of corn, yeast, gluten, barley, rice, sodium and sugar.
Seals/Symbols
Sustainably wildcrafted
Made with non GMO ingredients
K Parve Gluten free Vegan
Brand IP Statement(s)
Mirtoselect is a registered trademark of Indena S.p.A.
Mirtoselect an Indiana Product
General
1313C
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Standardized Bilberry Fruit Extract by Bluebonnet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Standardized Bilberry Fruit Extract by Bluebonnet
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Bilberry fruit extract
Interacts with275 drugs
Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...
Bilberry fruit extract monograph & interactionsOther (inactive) ingredients: Kosher Vegetable Capsules, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Standardized Bilberry Fruit Extract by Bluebonnet Drug Interactions
HelloPharmacist Interaction Report
Bluebonnet's Standardized Bilberry Fruit Extract contains one active ingredient — bilberry fruit extract — which does interact with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin, aspirin, or clopidogrel). Bilberry extract may slow down how your blood clots, raising the risk of bleeding if you're already on one of these medications.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you take diabetes medications. Bilberry might lower your blood sugar further, which could tip you into low blood sugar (hypoglycemia).
Additionally, there are moderate interactions with drugs broken down by a liver enzyme called CYP2E1, and with erlotinib (a cancer drug). In both cases, bilberry extract might weaken how well these medications work.
Altogether, these interactions span 274 individual medications. We'd recommend running your exact medications through the interaction checker below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Standardized Bilberry Fruit Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Standardized Bilberry Fruit Extract interact with 275 drugs. Click any drug to see the details.
1 of the 1 ingredient in Standardized Bilberry Fruit Extract interact with drugs. Each result below shows which ingredient is responsible. Bilberry fruit extract
Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Aspirin, Pentazocine interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Benzhydrocodone, Acetaminophen interactionBetrixabanBevyxxa
How Betrixaban interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Betrixaban interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
How Bivalirudin interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Bivalirudin interactionBromfenac SodiumBromsite, Prolensa
How Bromfenac Sodium interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Bromfenac Sodium interactionCabliviCablivi
How Cablivi interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Cablivi interactionCanagliflozinInvokana
How Canagliflozin interacts with Standardized Bilberry Fruit Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Fruit Extract + Canagliflozin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Standardized Bilberry Fruit Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bilberry fruit extract
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Standardized Bilberry Fruit Extract, from the product label.
Bluebonnet
- Name
- Bluebonnet Nutrition Corporation
- Street Address
- 12915 Dairy Ashford
- City
- Sugar Land
- State
- TX
- ZipCode
- 77478
- Web Address
- www.bluebonnetnutrition.com
Standardized Bilberry Fruit Extract by Bluebonnet: Common Questions
Does Standardized Bilberry Fruit Extract by Bluebonnet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is bilberry safe during pregnancy or while breastfeeding?
Will this help my eyesight?
What side effects might I notice?
Can I take this long-term?
What's the difference between bilberry food and this supplement?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Standardized Bilberry Fruit Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Standardized Bilberry Fruit Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Standardized Bilberry Fruit Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bilberry 14 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
- Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
- Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
- Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
- Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
- Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
- Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
- Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
- Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
- Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
- Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
- Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
- Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC