No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Sulbutiamine Ingredients & Drug Interactions

by BulkSupplements.com

Sulbutiamine label
See full label image
Powder Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sulbutiamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Sulbutiamine is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, memory and focus, mental clarity.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Sulbutiamine by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a single-ingredient product: sulbutiamine, a form of thiamine (vitamin B1). There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sulbutiamine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: fatigue and energy support.
  • We looked for evidence on: Fatigue, Multiple sclerosis-related fatigue, Low energy, Tiredness, Chronic fatigue.
  • The closest evidence on file: Sulbutiamine is rated "Insufficient Reliable Evidence To Rate" for Multiple sclerosis-related fatigue (Natural Medicines).

The evidence for sulbutiamine isn't established. Our data rates it as insufficient reliable evidence for fatigue, diabetic neuropathy (nerve damage from diabetes), and multiple sclerosis-related fatigue.

That doesn't mean it doesn't work — it means the research isn't strong enough yet to say whether it does.

The evidence, ingredient by ingredient Sulbutiamine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sulbutiamine has been used at 600 mg daily for up to 4 weeks without safety concerns in small clinical studies, but long-term safety data are limited. In those studies, a small number of trial participants reported headache, insomnia, tremor, drowsiness, or nausea, each at a rate of less than one percent.

The safety notes advise against use during pregnancy or while breastfeeding due to insufficient data.

Side effects, ingredient by ingredient Sulbutiamine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for sulbutiamine. Still, it's worth checking your exact medications with the tool on this page before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and some safety-information gaps remain.

Sulbutiamine may appeal to someone exploring options for fatigue or nerve-related symptoms, but the evidence for its effectiveness isn't strong. If you're pregnant or breastfeeding, the data don't support using it.

Talk with your pharmacist before starting, especially if you take other medications or have any health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sulbutiamine, straight from the product label.

Brand BulkSupplements.com
Net contents 50 Gram(s); 1.76 Ounce(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 254573
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sulbutiamine by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
200 mg
Maximum serving Sizes:
200 mg
Servings per container
250
IngredientAmount% DV
Sulbutiamine200 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

Precautions

Warning: Do not take this supplement if you have high blood pressure or are under 18 years of age.

This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Warning: Do not take this supplement if you have high blood pressure or are under 18 years of age.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Free of: Sugar, soy, dairy, yeast, gluten or additives

Suggested/Recommended/Usage/Directions

Directions: Take 200 milligrams once or twice daily, or as directed by a physician. Since the body forms a tolerance to this product, individual needs will vary. Use an accurate milligram scale to measure.

Storage

Storage: Keep dry, cool & dark

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sulbutiamine by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sulbutiamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sulbutiamine by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size200 mg Dosage formPowder Servings per container250 Amounts shown are per serving.

Sulbutiamine

No known
interactions
200 mg per serving

Sulbutiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) developed in Japan, often taken for fatigue and to support mental energy and foc...

Sulbutiamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sulbutiamine by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Sulbutiamine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Sulbutiamine, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Road
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Sulbutiamine by BulkSupplements.com: Common Questions

Does Sulbutiamine by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Sulbutiamine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Sulbutiamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take sulbutiamine if I'm pregnant or breastfeeding?
The safety data advise against it. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding, so it's best to avoid use during these times. Talk with your doctor or pharmacist about options if you need support for fatigue or another concern.
Does sulbutiamine actually work for fatigue?
The evidence isn't strong enough to say. Our data rate it as insufficient reliable evidence for fatigue. That means the research available doesn't give us a clear answer — not that it definitely doesn't work, but you shouldn't count on it.
How long can I safely take sulbutiamine?
It's been used safely at 600 mg daily for up to 4 weeks in the research we have, but long-term safety data are limited. If you're thinking of taking it longer than that, check with your pharmacist first.
What are the side effects?
In clinical studies, a small number of trial participants reported headache, insomnia, tremor, drowsiness, or nausea — each at less than one percent. Most people tolerated it well over the short term studied.
Does sulbutiamine interact with my medications?
No interactions are documented in our data for sulbutiamine. That said, it's smart to check your specific medications using the tool on this page or ask your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sulbutiamine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sulbutiamine label
Go deeper

The Full Monographs Behind Sulbutiamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sulbutiamine

Sulbutiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) developed in Japan, often taken for fatigue and to support mental energy and focus. Human evidence is limited and mostly...

Read the full Sulbutiamine monograph →
Sources

Sources & How We Checked

Sulbutiamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulbutiamine 4 references
  1. Shah S. Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. J Assoc Physicians India. 2003;51:891-5.
  2. Loo H, Poirier M, Ollat H, et al. [Effects of subutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes]. Encephale. 2000;26(2):70-5.
  3. Kiew K, Wan Mohamad W, Ridzuan A, et al. Effects of sulbutiamine on diabetic polyneuropathy: an open randomized controlled study in type 2 diabetics. Malays J Med Sci. 2002;9(1):21-7.
  4. Sevim S, Kaleagasi H, Tasdelen B. Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. Mult Scler Relat Disord. 2017;16:40-43. PubMed

See these in context on the Sulbutiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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