Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Super Noni 20,000 mg Ingredients & Drug Interactions

by GNC Natural Brand

Super Noni 20,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Noni 20,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Noni 20,000 mg is a dietary supplement by GNC Natural Brand with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 573 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Noni fruit extract, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Noni 20,000 mg by GNC Natural Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Noni 20,000 mg by GNC Natural Brand — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Noni 20,000 mg by GNC Natural Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 3 active ingredients.
  • “certified organic Noni fruit extract” is listed as a grouped ingredient — the label gives one combined amount (20,000 mg) without saying how much of each component you get.

Super Noni 20,000 mg is a liquid supplement with 3 active ingredients: sodium, fiber, and polysaccharides, plus certified organic noni fruit extract. The product also contains several inactive ingredients — fruit powders (strawberry, raspberry, blueberry, tart cherry, pomegranate, cranberry), quercetin, grape, resveratrol, citric acid, natural flavor, and xanthan gum — which serve as fillers and flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Sodium's overall clinical evidence instead.

Strong

Strong clinical evidence supports Sodium for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cystic fibrosis — rated "Likely Effective" (Natural Medicines).
  • On file: Amphotericin B nephrotoxicity — rated "Possibly Effective" (Natural Medicines).

The effectiveness data we hold covers sodium, not noni itself. Sodium is likely effective for cystic fibrosis and possibly effective for nephrotoxicity (kidney damage) caused by amphotericin B, an antifungal drug.

For bipolar disorder and congestive heart failure, the evidence is insufficient to rate. We don't hold effectiveness data for the fiber, polysaccharides, or noni fruit extract in this product.

The evidence, ingredient by ingredient Sodium Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated in normal dietary amounts, up to the recommended daily limit of 2.3 grams. Too much sodium is linked to high blood pressure and heart strain, and can worsen cardiovascular disease, hypertension, and kidney disease in susceptible people — these are rare but serious risks.

Avoid sodium supplements or very high intake without talking to your doctor first. One note: low sodium levels can increase osteoporosis risk, while very high intake has been associated with increased gastric cancer risk in population studies.

For pregnancy and lactation, sodium is rated likely safe, though one rating notes possibly unsafe — discuss this with your doctor or pharmacist if you're pregnant or breastfeeding and considering this product.

Side effects, ingredient by ingredient Sodium Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 205 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you take blood pressure medications (antihypertensives), lithium, corticosteroids (steroids), didanosine (HIV medication), tolvaptan, or sodium phosphate, or any other sodium-containing drugs. High sodium can make blood pressure medications less effective and can dangerously alter lithium levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is high in sodium, which can interfere with blood pressure medications, lithium, steroids, and HIV drugs, among others. If you take any regular medications — especially for heart, blood pressure, mood, or immune conditions — talk with your doctor or pharmacist before starting it.

Even if you don't take medications, ask your provider whether extra sodium is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Noni 20,000 mg, straight from the product label.

Brand GNC Natural Brand
Net contents 32 fl. Oz.; 946.3 mL
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2255
Product type Botanical
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Noni 20,000 mg by GNC Natural Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 fl. Oz.
Maximum serving Sizes:
2 fl. Oz.
Servings per container
32
IngredientAmount% DV
Calories30 {Calories}--
Total Carbohydrates8 Gram(s)3%
Sugar8 Gram(s)--
Sodium5 mg1%
Fiber0 Gram(s)--
Polysaccharides825 mg--
certified organic Noni fruit extract20000 mg--

Other ingredients: certified organic Cane, organic Strawberry powder, organic Raspberry powder, organic Blueberry powder, organic Tart Cherry powder, organic Pomegranate powder, organic Cranberry powder, Quercetin, Grape, Resveratrol, Citric Acid, Natural flavor, Xanthan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

dietary supplement

Suggested/Recommended/Usage/Directions

Directions: Shake well before each use. As a dietary supplement, drink one to two ounces per day. If desired, Super Noni may be mixed with your favorite juice.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Refrigerate after opening.

Store at room temperature.

Formula

Polysaccharides are beneficial complex carbohydrates. Each one ounce serving is standardized to contain 825 mg of polysaccharides.

Standardized Polysaccharides

General Statements

**Based on ORAC value of fruit and berries blend.

20,000mg

Antioxidant Support

Enhance your overall well being the Polynesian way, with pure, organic GNC Natural Brand Super Noni.

GNC

GNC Natural Brand Super Noni is a natural source of a variety of beneficial phytonutrients. Each one ounce serving supplies 20,000 milligrams of noni extract and the antioxidant capacity of more than three servings of fruit.**

GNC's Best

Immune System Support

Made in the USA

More antioxidant capacity than 3 standard servings of fruit**

Noni fruit has been a dietary staple of the Polynesian people for many years. The oldest references to noni date back centuries to India's ancient Sanskrit writings that cite noni for its Ayurvedic uses.

Noni is characterized by its vivid green, yellow color and pungent smell and taste.

SUPER NONI

Supports a health immune system*

Tahiti's finest

THE GOODNESS OF NONI

General

CODE 360770 LIG

Brand IP Statement(s)

GNC Natural Brand Super Noni is GNC's highest quality noni product. Each one ounce serving is concentrated to contain 20,000 milligrams of whole organic noni fruit extract and delivers the antioxidant capacity of more than three servings of fruit.** Antioxidants, natural substances found in fruits and vegetables, help protect the body against harmful free radicals that can destroy healthy cells and promote the cell aging process.

GNC Natural Brand Super Noni's unique patented blend includes naturally occurring Vitamin C-like compounds, as well as polysaccharides, to support your body's overall immune health and provide antioxidant protection.* Each one ounce serving contains 2,500 ORAC units (Oxygen Radical Absorption Capacity) from a blend of organic noni and other popular fruits and berries including; blueberry, grape seed and cranberry. The ORAC assay measures antioxidant capacity against free radicals.

GNC NATURAL BRAND(TM)

Formulation

Vegetarian

No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Dairy, No Wheat, No Gluten, Yeast Free.

Certified Organic by Organic Certifiers, Inc.

Organic

Seals/Symbols

USDA ORGANIC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Noni 20,000 mg by GNC Natural Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Noni 20,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Noni 20,000 mg by GNC Natural Brand

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 fl. Oz. Dosage formLiquid Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

8 Gram(s) per serving

Sodium

Interacts with
205 drugs
5 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Fiber

0 Gram(s) per serving

Certified organic Noni fruit extract

Interacts with
542 drugs
20000 mg per serving

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Certified organic Noni fruit extract monograph & interactions
  • › Polysaccharides

Other (inactive) ingredients: Certified organic Cane, Organic Strawberry powder, Organic Raspberry powder, Organic Blueberry powder, Organic Tart Cherry powder, Organic Pomegranate powder, Organic Cranberry powder, Quercetin, Grape, Resveratrol, Citric Acid, Natural flavor, Xanthan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Noni 20,000 mg by GNC Natural Brand Drug Interactions

Want to check YOUR meds against Super Noni 20,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
573Drugs
572 Moderate 1 Minor

Ingredients driving the most interactions

certified organic Noni fruit extract 542
Sodium 205

Individual Drug Interactions

The ingredients in Super Noni 20,000 mg interact with 573 drugs. Click any drug to see the details.

2 of the 4 ingredients in Super Noni 20,000 mg interact with drugs. Each result below shows which ingredient is responsible. certified organic Noni fruit extract Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Noni 20,000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Noni fruit extract8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
certified organic Noni fruit extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Noni 20,000 mg, from the product label.

GNC Natural Brand

See all GNC Natural Brand products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Super Noni 20,000 mg by GNC Natural Brand: Common Questions

Does Super Noni 20,000 mg by GNC Natural Brand interact with any medications?
Yes. Based on its ingredients, Super Noni 20,000 mg has a known interaction with 573 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Noni 20,000 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is sodium safe to take as a supplement?
Sodium in normal dietary amounts is well tolerated, but sodium supplements carry risk — especially high intake. Too much is linked to high blood pressure, heart problems, and kidney strain. Avoid supplementing sodium without your doctor's approval, and stick to normal dietary amounts.
Will this product affect my blood pressure medication?
Yes — high sodium intake can reduce how well blood pressure medications work and may require you to take higher doses. If you're on a blood pressure medication, talk with your doctor or pharmacist before taking this product.
Can I take this if I'm on lithium?
Not without checking with your doctor first. Sodium directly affects lithium levels: high sodium lowers lithium levels and reduces its effect, while low sodium can raise lithium to toxic levels. Your doctor or pharmacist needs to know before you add this product.
What is noni fruit extract used for in this product?
The product facts we hold don't describe the intended use of the noni fruit extract itself — we have effectiveness data only for the sodium component. Ask your doctor or pharmacist or check the label or manufacturer's website for the intended purpose of noni in this formula.
Is this safe if I'm pregnant or breastfeeding?
Sodium is rated likely safe in pregnancy and lactation, though one rating notes possibly unsafe. There isn't enough data to be certain, so talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.
Does this product have any fillers?
Yes — it contains several inactive ingredients including fruit powders, xanthan gum, citric acid, natural flavor, and other compounds. These serve as fillers and flavor; the active components are sodium, fiber, polysaccharides, and noni fruit extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Noni 20,000 mg label
Go deeper

The Full Monographs Behind Super Noni 20,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Super Noni 20,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
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See these in context on the Sodium monograph →

Noni 16 references
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See these in context on the Noni monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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