SuperFlex UC-ll Ingredients & Drug Interactions
What is this page for?
First and foremost: checking SuperFlex UC-ll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SuperFlex UC-ll is a dietary supplement by NewtonEverett with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of SuperFlex UC-ll by NewtonEverett
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
SuperFlex UC-II has three active ingredients. Hyaluronic acid is a naturally occurring substance that helps retain moisture in tissues.
Boron glycinate is a form of boron, a mineral that plays a role in bone and joint health. The product also contains total collagen and a UC-II standardized cartilage blend, both of which are structural proteins meant to support connective tissue.
The capsule itself and the rice flour, magnesium stearate, and silicon dioxide are inactive ingredients that help hold the formula together.
Does it work?
Not established
Hyaluronic acid is possibly effective for dry eye and venous leg ulcers (slow-healing wounds on the legs). For aging skin, hay fever, and sexual dysfunction, the evidence we hold is not reliable enough to rate it either way.
Boron is likely effective for correcting boron deficiency and possibly effective for vaginal yeast infections and radiation-related skin damage. For the collagen and cartilage components, the evidence isn't established in the data we hold.
How safe is it?
Well-documented data
Hyaluronic acid is generally well tolerated when taken by mouth or applied to skin, though long-term safety of supplements hasn't been fully studied. The safety data for oral supplements is limited, so talk with your doctor before starting unless they've already cleared it.
Boron is generally safe at the doses found in low-dose supplements and food, but high doses can be toxic. Avoid boron supplements if you're pregnant or breastfeeding, as high amounts may harm the fetus and safety data during lactation is too limited.
Boron in high chronic doses or acute overdose can cause skin problems, nausea, vomiting, and diarrhea.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, we have no interaction data for the total collagen ingredient, so if you take medications or have health concerns, run this product through the interaction checker below or talk with your pharmacist to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
This product is designed to support joint and connective tissue health through hyaluronic acid, boron, and collagen. No drug interactions are documented for the ingredients we have data on, though we couldn't check the collagen component.
If you're pregnant, breastfeeding, or take any regular medications, talk with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SuperFlex UC-ll, straight from the product label.
| Brand | NewtonEverett |
|---|---|
| Barcode (UPC) | 818423027845 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 213330 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SuperFlex UC-ll by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hyaluronic Acid | 3.3 mg | -- |
| Boron Glycinate | 5 mg | -- |
| total Collagen | 10 mg | -- |
| UC-II standardized Cartilage Blend | 40 mg | -- |
Other ingredients: HPMC Vegetable Capsule, Rice Flour, Vegetable Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
SuperFlex-UC-II with undenatured type II collagen provides convenient & effective joint, cartilage and bone health. Just one small capsule daily contain three advanced ingredients for increased comfort and mobility to support your active lifestyle.
UC-II is derived from protein found in natural cartilage. It works to promote a healthy immune response for improved joint and cartilage health Hyaluronic Acid provides cushioning and lubrication for joint comfort Boron improves absorption of calcium, magnesium and vitamin D for strong, healthy bones
UC-II collagen 10 mg Boron 5 mg Hyaluronic acid 3.3 mg
Brand IP Statement(s)
UC-II is a registered trademark of InterHealth N.I. UC-II brand collagen with undenatured type II collagen (U.S. Patents 7,846,487, 7,083,820 and EPO Patent EP1435906B1; Canadian patent CA2459981C; and Japanese Patent JP 4800574B2).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Joint, cartilage & bone Advanced action
Flexability Comfort Mobility
Suggested/Recommended/Usage/Directions
Just 1 small capsule per day
Suggested Use: Take 1 capsule daily.
FDA Statement of Identity
Dietary Supplement
Precautions
Warning: Consult a physician before using if pregnant, nursing or on medication.
Do not use if safety seal is broken. Do not exceed suggested daily intake.
Keep out of reach of children.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SuperFlex UC-ll by NewtonEverett label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SuperFlex UC-ll by NewtonEverett
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hyaluronic Acid
No knowninteractions
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...
Hyaluronic Acid monograph & interactionsBoron Glycinate
No knowninteractions
Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...
Boron Glycinate monograph & interactionsUC-II standardized Cartilage Blend
- › Total Collagen
Other (inactive) ingredients: HPMC Vegetable Capsule, Rice Flour, Vegetable Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
SuperFlex UC-ll by NewtonEverett Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in SuperFlex UC-ll. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for SuperFlex UC-ll, from the product label.
NewtonEverett
See all NewtonEverett products- Name
- Newton-Everett Biotech
- Street Address
- PO Box 27793
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85255
- Phone Number
- 866.593.3424
- Web Address
- www.newton-everett.com
SuperFlex UC-ll by NewtonEverett: Common Questions
Does SuperFlex UC-ll by NewtonEverett interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is hyaluronic acid in this product the same as what's in skin creams?
Can I take this while I'm pregnant?
Is it safe to breastfeed while taking this?
What side effects might I notice?
Does this product actually help with joint health?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SuperFlex UC-ll is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SuperFlex UC-ll’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph → Herb & supplement monographBoron
Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...
Read the full Boron monograph →Sources & How We Checked
SuperFlex UC-ll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 10 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Boron 6 references
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
- Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
- Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
- Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC