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Dietary supplement

Supreme Saffron Extract Ingredients & Drug Interactions

by Nature's Truth

Supreme Saffron Extract label
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Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Supreme Saffron Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Supreme Saffron Extract is a dietary supplement by Nature's Truth with 1 active ingredient. Its ingredients are commonly taken for depression and low mood, anxiety, pms symptoms.Based on those ingredients, 521 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saffron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Supreme Saffron Extract by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with Supreme Saffron Extract by Nature's Truth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Supreme Saffron Extract by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Saffron” is listed as a grouped ingredient — the label gives one combined amount (88.50 mg) without saying how much of each component you get.

Nature's Truth Supreme Saffron Extract is a single-ingredient supplement: saffron stigma extract, the deep-red dried threads from the saffron crocus flower. The inactive ingredients are cellulose, gelatin, magnesium stearate, and silica — standard capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Saffron's overall clinical evidence instead.

Moderate

Some clinical evidence supports Saffron for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).
  • On file: Chemotherapy-induced peripheral neuropathy — rated "Possibly Effective" (Natural Medicines).

The evidence we hold shows saffron extract is possibly effective for chemotherapy-induced peripheral neuropathy (nerve pain from cancer drugs) and Alzheimer disease. For other uses, the effectiveness data isn't established in our records.

Talk with your pharmacist about whether saffron fits your situation.

The evidence, ingredient by ingredient Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saffron extract is generally well tolerated when taken by mouth. The most common side effects in trials were gastrointestinal complaints, nausea, sedation, and vomiting.

Rarely, anaphylaxis has been reported, and allergy to saffron — including anaphylactic shock — can occur within minutes of eating food prepared with it. High doses can be toxic, so supplement amounts should be used carefully.

At very high doses, some trial participants reported anxiety or agitation, though these are uncommon. The safety data advises against saffron in medicinal or supplement amounts during pregnancy, as it may stimulate the uterus.

There isn't enough reliable safety information for breastfeeding — talk with your pharmacist or doctor before taking it if you're nursing.

Side effects, ingredient by ingredient Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saffron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 521 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you use central nervous system depressants (sedatives, sleep aids, narcotic pain relievers), blood pressure medications, diabetes drugs, or consume significant caffeine. These are the main medication types documented to interact with saffron extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Saffron extract may help with nerve pain from chemotherapy or Alzheimer disease, but it interacts with blood pressure drugs, diabetes medications, CNS depressants, and caffeine. If you take any prescription medication, check it against our tool before starting.

If you're pregnant, skip this product; if you're breastfeeding or have food or occupational saffron allergies, talk with us first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Supreme Saffron Extract, straight from the product label.

Brand Nature's Truth
Barcode (UPC) 840093123879
Net contents 60 Quick Release Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338579
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Supreme Saffron Extract by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Quick Release Capsule(s)
Maximum serving Sizes:
1 Quick Release Capsule(s)
Servings per container
60
UPC/BARCODE
840093123879
IngredientAmount% DV
Saffron88.5 mg--
Saffron Stigma Extract44.25 mg--

Other ingredients: Cellulose, Gelatin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) quick release capsule twice daily (morning and evening), preferably with meals.

Formulation

Free of gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives.

Our non-GMO pledge visit our website Non-GMO Gluten free

Precautions

Warning: Not intended for use by pregnant or nursing women or persons under the age of 18. If you are taking any medications, including blood thinners, planning any medical or surgical procedure or have any medical condition, including blood coagulation or blood pressure disorders, consult your doctor before use.

Warning: Not intended for use by pregnant or nursing women or persons under the age of 18. Keep out of reach of children.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2024 Nature's Truth LLC

FDA Statement of Identity

Herbal Supplement

Formula

Premium concentrated saffron extract

Seals/Symbols

100% Quality Satisfaction Guarantee

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Supreme Saffron Extract by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Supreme Saffron Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Supreme Saffron Extract by Nature's Truth

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Quick Release Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Saffron

Interacts with
521 drugs
88.5 mg per serving

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron monograph & interactions

Other (inactive) ingredients: Cellulose, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Supreme Saffron Extract by Nature's Truth Drug Interactions

Want to check YOUR meds against Supreme Saffron Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
521Drugs
521 Moderate

Ingredients driving the most interactions

Saffron 521

Individual Drug Interactions

The ingredients in Supreme Saffron Extract interact with 521 drugs. Click any drug to see the details.

1 of the 1 ingredient in Supreme Saffron Extract interact with drugs. Each result below shows which ingredient is responsible. Saffron

Each ingredient & the kinds of drugs it affects

For each ingredient in Supreme Saffron Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saffron4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Supreme Saffron Extract, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-844-544-1030
Web Address
NaturesTruth.com
Pharmacist Counseling Corner

Supreme Saffron Extract by Nature's Truth: Common Questions

Does Supreme Saffron Extract by Nature's Truth interact with any medications?
Yes. Based on its ingredients, Supreme Saffron Extract has a known interaction with 521 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Supreme Saffron Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No. The safety data advises against saffron in supplement amounts during pregnancy because it may stimulate the uterus. Talk with your doctor or pharmacist if you're planning to become pregnant or are already pregnant.
Is it safe to breastfeed while taking saffron extract?
There isn't enough reliable safety information to know either way. Talk with your pharmacist or doctor for personalized advice if you're nursing.
What are the most common side effects?
In clinical trials, the most common side effects were gastrointestinal complaints, nausea, sedation, and vomiting. Most people tolerate it well, but sedation is something to watch for — especially if you're also taking sleep aids or other sedating drugs.
Can someone with a saffron allergy take this?
No. Allergic reactions to saffron, including serious anaphylactic shock, have been reported in clinical trials and can happen within minutes of exposure. If you've ever had an allergic reaction to saffron or occupational symptoms like allergy-induced asthma from saffron exposure, avoid this product.
Does saffron extract actually work for nerve pain or Alzheimer disease?
The evidence we hold rates saffron as possibly effective for both chemotherapy-induced peripheral neuropathy (nerve pain from cancer drugs) and Alzheimer disease, meaning there's some clinical support but it's not definitive. Talk with your doctor about whether it makes sense for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Supreme Saffron Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Supreme Saffron Extract label
Go deeper

The Full Monographs Behind Supreme Saffron Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Supreme Saffron Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed
  16. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

See these in context on the Saffron monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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