Sweet Zap Mint Ingredients & Drug Interactions
by Seynani
What is this page for?
First and foremost: checking Sweet Zap Mint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sweet Zap Mint is a dietary supplement by Seynani with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 920 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre extract, Holy Basil extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sweet Zap Mint by Seynani
Ask about any prescription or over-the-counter medication and we check it for interactions with Sweet Zap Mint by Seynani — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sweet Zap Mint by Seynani
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Sweet Zap Mint is a liquid with 2 active ingredients: gymnema sylvestre extract and holy basil extract. Gymnema has a long history in traditional medicine for blood sugar support, while holy basil is used in traditional practice for general wellness and stress.
The product also contains inactive ingredients — purified water, vegetable glycerin, peppermint oil, potassium sorbate, and silicon dioxide — which serve as the liquid base, preservative, and flavoring.
Does it work?
Not established
The evidence we hold doesn't establish that either ingredient works for its intended purposes. Gymnema is rated insufficient reliable evidence to rate for diabetes, prediabetes, obesity, and metabolic syndrome.
Holy basil similarly has insufficient reliable evidence for generalized anxiety, asthma, headache, respiratory infections, dental plaque, and diabetes. Neither ingredient has a proven effectiveness rating in our data.
How safe is it?
Well-documented data
Gymnema is generally well tolerated short-term, but it can lower blood sugar — a real concern if you have diabetes or take blood sugar medications. Quality varies between products.
A rare case of drug-induced liver inflammation (hepatitis) has been reported with gymnema tea used heavily over 10 days; the patient recovered after 6 months with medical treatment. Holy basil is generally well tolerated short-term in adults, though long-term safety data are limited.
The most common side effects reported are loose stools and nausea. Gymnema is not recommended during pregnancy or while breastfeeding due to insufficient safety data.
Holy basil is rated possibly unsafe in pregnancy and should be avoided while breastfeeding as well.
Meds to double-check
Moderate interaction found
Before you start Sweet Zap Mint, double-check with your doctor or pharmacist if you take antidiabetes medications — the risk of low blood sugar is moderate and real. Also flag blood thinners (anticoagulants) and antiplatelet drugs, which may carry increased bleeding risk.
If you take pentobarbital or any drug metabolized by your liver's CYP1A2, CYP2C9, or CYP3A4 systems, run it through the checker on this page.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Sweet Zap Mint is not established to work for any condition in the data we hold. The bigger issue is that both ingredients interact with blood sugar medications and other drugs, and gymnema has documented liver safety concerns in rare cases.
If you take antidiabetes drugs, blood thinners, pentobarbital, or any CYP1A2, CYP2C9, or CYP3A4 substrate medications, you need to check with your doctor or pharmacist before using this product. Pregnant or breastfeeding people should not take it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sweet Zap Mint, straight from the product label.
| Brand | Seynani |
|---|---|
| Barcode (UPC) | 697691508726 |
| Net contents | 0.27 Fluid Ounce(s); 8 mL |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 242602 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sweet Zap Mint by Seynani, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1.23 mg | -- |
| Gymnema sylvestre extract | 0 NP | -- |
| Holy Basil extract | 0 NP | -- |
Other ingredients: purified Water, Vegetable Glycerin, Peppermint Oil, Potassium Sorbate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Retrain Your Brain When you spray Sweet Zap on your tongue, the natural blend fills the sweet receptors located on the taste buds. Sweet Zap works on both sugar and artificial sweeteners by safely and temporarily blocking your ability to taste sweet. By blocking your ability to taste sweet, Sweet Zap can help retrain your brain to stop eating sweets altogether. Transitioning to a low or no-sugar diet reduces hunger and cravings, helps you burn fat, increases energy level, and reduces inflammation.
Sugar blocker mint spray
All natural no artificial flavors non-stimulant Gluten free Made with non-GMO ingredients
Suggested/Recommended/Usage/Directions
Sweet Zap is a conditioning tool. To increase your success: 1. Spray Sweet Zap on the tongue 2. Try the sweet you're craving
For regular use: Use 2-3 times daily or as often as needed. Sweet Zap is a conditioning tool. Suggested routine for success: If you eat sweets after breakfast or have sweets for breakfast, spray Sweet Zap and try that treat again. If you eat sweet treats after lunch, spray Sweet Zap after lunch and try that treat again. If you eat sweet treats after lunch, spray Sweet Zap after dinner or after you eat some of that dessert and try the dessert to avoid overeating.
Suggested Use: As a dietary supplement, spray Sweet Zap (1-2 times) directly on the tongue ensuring you cover the tip. Use Sweet Zap as often as needed to avoid cravings from sugar and artificial sweeteners and help maintain a healthy diet.
General Statements
End sugar cravings
Up to 77 servings
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to cure, diagnose, treat or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sweet Zap Mint by Seynani label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sweet Zap Mint by Seynani
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.104 mL Dosage formLiquid Servings per container77 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Purified Water, Vegetable Glycerin, Peppermint Oil, Potassium Sorbate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Sweet Zap Mint by Seynani Drug Interactions
HelloPharmacist Interaction Report
Sweet Zap Mint by Seynani contains gymnema sylvestre extract and holy basil extract, both of which interact with medications.
The most serious concern is a moderate-severity interaction with antidiabetes drugs — both ingredients can lower blood sugar, and gymnema has been shown in human studies to enhance the blood glucose-lowering effects of diabetes medications, raising the risk of low blood sugar (hypoglycemia).
Read the full breakdown — every affected drug type, severity by severity
Gymnema also interacts with several enzyme systems in your liver. It can affect how your body processes drugs metabolized by CYP1A2 and CYP2C9 enzymes (moderate severity), potentially changing drug levels in unpredictable ways — sometimes raising them, sometimes lowering them.
Gymnema specifically increases clearance of tolbutamide, a diabetes drug, which could reduce its effectiveness. Holy basil adds moderate-severity interactions with blood thinners (anticoagulants) and antiplatelet drugs, where animal research suggests it may increase bleeding risk, though human data are limited.
Holy basil may also enhance the sedative effects of pentobarbital.
Gymnema theoretically affects CYP3A4 substrates as well, though the evidence is mixed (minor severity). Altogether, these interactions span 921 individual medications.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sweet Zap Mint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sweet Zap Mint interact with 920 drugs. Click any drug to see the details.
2 of the 2 ingredients in Sweet Zap Mint interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre extract Holy Basil extract
AsenapineSaphris, Secuado
How Asenapine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Asenapine interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Butalbital, Caffeine interactionGymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine interactionGymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Codeine Phosphate interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Dover's Pwd interactionGymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Hydrocodone interactionGymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Phenacetin +1 Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Orphenadrine interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractPhenacetin, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Read the full Gymnema Sylvestre Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionGymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Hydrocodone interactionGymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Aspirin, Omeprazole interactionGymnema Sylvestre ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Read the full Gymnema Sylvestre Extract + Aspirin, Omeprazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sweet Zap Mint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Gymnema sylvestre extract
Antidiabetes Drugs
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.
Phenacetin
Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.
Tolbutamide (Orinase)
Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.
Holy Basil extract
Anticoagulant/Antiplatelet Drugs
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.
Antidiabetes Drugs
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.
Pentobarbital (Nembutal)
Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Brand information
Manufacturer and brand details for Sweet Zap Mint, from the product label.
Seynani
See all Seynani products- Name
- Seynani, LLC
- Street Address
- PO Box 909
- City
- Falls Church
- State
- VA
- ZipCode
- 22046
Sweet Zap Mint by Seynani: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Sweet Zap Mint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gymnema
Interacts with 851 drugsGymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...
Read the full Gymnema monograph → Herb & supplement monographHoly Basil
Interacts with 212 drugsHoly basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...
Read the full Holy Basil monograph →Sources & How We Checked
Sweet Zap Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gymnema 12 references
- Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
- Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
- Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
- Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
- Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
- Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
- Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
- Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
- Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
- Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
- Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
- Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed
Holy Basil 8 references
- Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
- Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
- Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
- Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
- Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
- Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
- Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
- Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC