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Dietary supplement

Trimethylglycine TMG 1000 mg Ingredients & Drug Interactions

by tnvitamins

Trimethylglycine TMG 1000 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trimethylglycine TMG 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Trimethylglycine TMG 1000 mg is a dietary supplement by tnvitamins with 1 active ingredient. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Trimethylglycine TMG 1000 mg by tnvitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: betaine anhydrous (also called trimethylglycine or TMG). Betaine is a compound that plays a role in your body's methylation process—essentially how cells copy and repair DNA and manage certain amino acids.

The tablet also contains inactive ingredients like microcrystalline cellulose and magnesium stearate, which are binders and flow agents that help hold the tablet together and keep it stable.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Betaine Anhydrous's overall clinical evidence instead.

Strong

Strong clinical evidence supports Betaine Anhydrous for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Homocystinuria — rated "Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).

Betaine anhydrous is effective for homocystinuria (an inherited metabolic condition marked by high homocysteine levels). It's possibly effective for high homocysteine levels in the blood (hyperhomocysteinemia) in general.

The evidence for other uses—including nonalcoholic fatty liver (NASH), colorectal adenoma, depression, and reflux (GERD)—is insufficient; we don't have enough reliable data to say whether it works for those.

The evidence, ingredient by ingredient Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine anhydrous is generally well tolerated at studied doses, but the safety data available is limited. The most common side effects reported are body odor, diarrhea, nausea, vomiting, stomach upset, and elevated cholesterol levels.

A serious side effect—brain swelling (cerebral edema)—is rare but has been reported. Safety during breastfeeding is not well established, so caution is advised if you're nursing.

Because overall safety data is sparse, it's best to check with your doctor or pharmacist before starting unless a doctor has already recommended it for you.

Side effects, ingredient by ingredient Betaine Anhydrous

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for betaine anhydrous. That said, check your exact medications with the search tool on this page, and talk to your pharmacist if you take anything regularly.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

If your doctor has recommended betaine for homocystinuria or high homocysteine levels, this product may be a fit. If you're considering it for another reason, talk to your pharmacist or doctor first—the evidence for most other uses isn't solid yet.

Because long-term safety data is limited and side effects can occur, it's worth a conversation before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trimethylglycine TMG 1000 mg, straight from the product label.

Brand tnvitamins
Barcode (UPC) X004FI1DZF
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336950
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trimethylglycine TMG 1000 mg by tnvitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
60
UPC/BARCODE
X004FI1DZF
IngredientAmount% DV
Betaine Anhydrous1000 mg--

Other ingredients: Dicalcium Phosphate Dihydrate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) tablets daily with or between meals, or as directed by a healthcare professional.

Precautions

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

New

Formula

Betaine Anhydrous 1000 mg per serving

FDA Statement of Identity

Dietary Supplement

Formulation

Free of: gluten, milk, eggs, crustaceans, fish, peanuts, tree nuts, and soy. GMO free

Seals/Symbols

Made in the USA Sourced Globally Manufactured in GMP Certified Facilities FDA Compliant

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trimethylglycine TMG 1000 mg by tnvitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trimethylglycine TMG 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trimethylglycine TMG 1000 mg by tnvitamins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Betaine Anhydrous

No known
interactions
1000 mg per serving Form: Trimethylglycine

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate Dihydrate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trimethylglycine TMG 1000 mg by tnvitamins Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Trimethylglycine TMG 1000 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Trimethylglycine TMG 1000 mg, from the product label.

tnvitamins

See all tnvitamins products
Name
Total Nutrition Inc.
City
Deer Park
State
NY
ZipCode
11729
Phone Number
1 (800) 245-7955
Web Address
TNVitamins.com
Pharmacist Counseling Corner

Trimethylglycine TMG 1000 mg by tnvitamins: Common Questions

Does Trimethylglycine TMG 1000 mg by tnvitamins interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Trimethylglycine TMG 1000 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Trimethylglycine TMG 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is betaine anhydrous, and what's it supposed to do?
Betaine anhydrous (also called TMG) is a compound that helps your body's cells with DNA repair and amino acid management. It's proven effective for homocystinuria, a genetic condition that causes dangerously high homocysteine. For other uses, like fatty liver or depression, the evidence just isn't there yet.
What side effects should I watch for?
Most common are body odor, diarrhea, nausea, vomiting, and stomach upset. Elevated cholesterol has also been reported. A rare serious side effect is brain swelling (cerebral edema). Start with your doctor's dose and report anything unusual.
Is it safe to take while breastfeeding?
Safety while breastfeeding isn't well established, so caution is advised. Talk to your doctor or pharmacist before taking it if you're nursing.
Can I take this with my regular medications?
No interactions are documented in our data for betaine anhydrous. Use the medication checker on this page with your specific drugs, and ask your pharmacist to be sure.
Does this actually work for high cholesterol or fatty liver?
The evidence for those uses isn't strong enough to say. Betaine is proven effective only for homocystinuria. For other conditions, there isn't enough reliable research yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Trimethylglycine TMG 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trimethylglycine TMG 1000 mg label
Go deeper

The Full Monographs Behind Trimethylglycine TMG 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Trimethylglycine TMG 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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