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Dietary supplement

Lutein 20 mg Ingredients & Drug Interactions

by tnvitamins

Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 20 mg is a dietary supplement by tnvitamins with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein 20 mg by tnvitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 20 mg by tnvitamins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein 20 mg by tnvitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 2 active ingredients: lutein and zeaxanthin. Both are carotenoids—natural pigments found in leafy greens and other plant foods that concentrate in your eye, especially the macula (the part of the retina responsible for sharp central vision).

The product is made up with safflower oil, gelatin, vegetable glycerin, yellow beeswax, annatto extract, and titanium dioxide as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and age-related macular degeneration support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, but the evidence isn't strong enough to say it works. It's not likely to help with retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, or bronchopulmonary dysplasia.

Zeaxanthin is also possibly effective for AMD. For other uses like cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, there isn't enough reliable evidence yet to know whether zeaxanthin helps.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from food and at typical supplement doses is generally well tolerated—doses up to 20 mg daily have not caused adverse effects in trials. Both lutein and zeaxanthin are rated Likely Safe in pregnancy and lactation, though the safety data for concentrated supplement doses during these periods is limited.

If you're pregnant or nursing, talk with your doctor or pharmacist about whether this product is right for you. Lutein is naturally present in breast milk, but there isn't enough data on higher supplement doses to be certain, so caution is warranted.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact antidiabetes drugs before taking this product. Zeaxanthin may theoretically increase the risk of low blood sugar (hypoglycemia) when combined with diabetes medications, though population studies haven't confirmed this in people eating more of these substances from food.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're concerned about age-related macular degeneration or cataracts, this combination may be worth discussing with your eye doctor, since both ingredients show some promise for those conditions. If you take a diabetes medication, clear it with your doctor or pharmacist first because of zeaxanthin's theoretical effect on blood sugar.

During pregnancy or breastfeeding, check with your healthcare provider before starting, even though the safety rating is Likely Safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 20 mg, straight from the product label.

Brand tnvitamins
Barcode (UPC) 095234190627
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217899
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 20 mg by tnvitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
095234190627
IngredientAmount% DV
Lutein20 mg--
Zeaxanthin1 mg--

Other ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, Annatto extract color, Titanium Dioxide color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

With zeaxanthin

FDA Statement of Identity

Dietary Supplement

Formulation

Free of: Gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non GMO.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel, preferably with a meal, or as directed by a health care professional.

Precautions

Caution: Pregnant or lactating women should consult a doctor before use.

If you are under medical supervision, please consult a doctor before use. Discontinue use and consult a doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

Reorder tnvitamins.com 800-645-4446

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 20 mg by tnvitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 20 mg by tnvitamins

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
20 mg per serving Form: Marigold petal extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
1 mg per serving Form: Marigold petal extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Annatto extract color, Titanium Dioxide color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 20 mg by tnvitamins Drug Interactions

Want to check YOUR meds against Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein 20 mg, from the product label.

tnvitamins

See all tnvitamins products
Name
Total Nutrition, Inc.
City
Farmingdale
State
NY
ZipCode
11735
Phone Number
1-800-645-4446
Web Address
www.tnvitamins.com
Pharmacist Counseling Corner

Lutein 20 mg by tnvitamins: Common Questions

Does Lutein 20 mg by tnvitamins interact with any medications?
Yes. Based on its ingredients, Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 20 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually prevent macular degeneration or cataracts?
The evidence suggests lutein and zeaxanthin are possibly effective for both age-related macular degeneration and cataracts, but 'possibly effective' means the research is promising, not definitive. Talk with your eye doctor about whether this makes sense for your situation.
Is it safe to take this while I'm pregnant or breastfeeding?
Both ingredients are rated Likely Safe in pregnancy and lactation, but the safety data on concentrated supplement doses during these times is limited. It's best to check with your doctor or pharmacist before starting, especially if you're nursing, so they can give you personalized advice.
I'm diabetic—can I safely take this?
Zeaxanthin may theoretically increase the risk of low blood sugar when taken with diabetes medications. Let your doctor or pharmacist know before you start so they can help you monitor your blood sugar and make sure it's safe for you.
What are these ingredients, and why are they in eye supplements?
Lutein and zeaxanthin are natural plant pigments called carotenoids that accumulate in the retina, especially in the macula—the part of your eye responsible for sharp center vision. That's why they're thought to support eye health.
Will this cause any side effects?
Doses up to 20 mg of lutein daily haven't produced adverse effects in trials, and zeaxanthin is generally well tolerated at typical supplement amounts. If you notice anything unusual after starting, mention it to your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 20 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 20 mg label
Go deeper

The Full Monographs Behind Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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