Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) Ingredients & Drug Interactions

by Solgar

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) is a dietary supplement by Solgar with 5 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 459 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A, Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Carotenoid Blend” is a proprietary blend — the label gives one combined amount (816 mcg) without saying how much of each component you get.

This softgel contains five active carotenoid and vitamin ingredients. The main players are zeaxanthin and lutein — both yellow pigments that concentrate in the eye — plus vitamin A (which also supports vision and skin), and a blend of other carotenoids that includes alpha-carotene and cryptoxanthin.

Zeaxanthin and lutein are the ones we've checked most thoroughly for interactions; alpha-carotene and cryptoxanthin are present but we hold no interaction data for them yet. The softgel is filled with soybean oil, safflower oil, and gelatin to deliver the carotenoids; the inactive ingredients also include beeswax, vegetable glycerin, annatto extract (a natural colorant), zinc oxide, and radish powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy vision, skin health and immune function.
  • We looked for evidence on: Acne, Aging skin, Asthenopia (eye strain), Cataracts, Age-related macular degeneration (AMD), Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Vitamin A is rated "Possibly Effective" for Aging skin, Night vision.

Zeaxanthin is possibly effective for age-related macular degeneration (AMD) — the progressive eye condition that can blur central vision as you age — but the evidence for other conditions (cognitive decline, Alzheimer's disease, asthma, and others in the data) is not established. Vitamin A is effective for correcting vitamin A deficiency, and possibly effective for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia.

Lutein is possibly effective for AMD and cataracts, though the data shows it's likely ineffective for retinitis pigmentosa, retinopathy of prematurity, and some other conditions.

The evidence, ingredient by ingredient Vitamin A Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well tolerated at recommended doses, but the facts emphasize a critical caveat: it builds up in your body over time, and high doses can be toxic. Serious side effects from very high doses are rare but can include liver damage, brain swelling (pseudotumor cerebri), and in extreme cases, coma or death.

Chronic use of large amounts causes fatigue, dry and itchy skin, hair loss, and brittle nails. Zeaxanthin and lutein are generally well tolerated; lutein at doses up to 20 mg daily has not produced adverse effects in the data we hold.

During pregnancy, the safety data advises caution with both zeaxanthin and lutein supplements (though the data is insufficient to say they're unsafe) — food sources are fine, but concentrated supplements haven't been studied enough. Vitamin A has mixed ratings: normal amounts are likely safe in pregnancy, but high doses (especially as retinol) are possibly unsafe and can cause birth defects.

During breastfeeding, lutein is likely safe, and normal dietary amounts of vitamin A are fine, but avoid high-dose vitamin A supplements unless your doctor directs it.

Side effects, ingredient by ingredient Vitamin A Zeaxanthin Lutein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin A, Zeaxanthin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 460 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take retinoids (such as isotretinoin or tretinoin) — this is a Major interaction. Also flag it if you take warfarin or another blood thinner, any tetracycline antibiotic, drugs that stress the liver, or diabetes medications.

The most serious concern is retinoids; the others are Moderate-level but still important to confirm.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is geared toward supporting eye health, particularly if you're concerned about age-related macular degeneration. If you take retinoids, warfarin, tetracycline antibiotics, or diabetes medications, check with your doctor or pharmacist before adding it — the interactions can affect how those drugs work or increase side effects.

The vitamin A dose here is moderate, but because vitamin A accumulates in the body, watch out for signs of overdose (dry skin, fatigue, hair loss) and avoid stacking it with other vitamin A or retinoid supplements. Talk with your own doctor or pharmacist before starting, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU), straight from the product label.

Brand Solgar
Barcode (UPC) 033984020320
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 263835
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
033984020320
IngredientAmount% DV
Calories5 Calorie(s)--
Zeaxanthin0 NP--
Vitamin A7500 mcg833%
Carotenoid Blend816 mcg--
Alpha-Carotene0 NP--
Cryptoaxanthin0 NP--
Lutein0 NP--

Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Safflower Oil, yellow Beeswax, Annatto extract, Zinc Oxide, Radish powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Beta-carotene is referred to as pro-vitamin A because it is converted into vitamin A as the body requires it. This phytonutrient is an antioxidant and an essential nutrient for healthy vision, skin health and the maintenance of a healthy immune system. This formulation utilizes naturally sourced, oceanic beta-carotene derived from the algae D. salina. It is offered in oil-based softgels to promote optimal absorption and assimilation.

Vitamin A activity D. salina Contains other naturally occurring carotenoids

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

For more information, call toll-free 1-877-SOLGAR 4, www.solgar.com

Brand IP Statement(s)

Copyright 2019 Solgar, Inc.

Solgar Since 1947

Formulation

Gluten, wheat & dairy free

Free of: Gluten, wheat, dairy, yeast, sugar, sodium, artificial flavor and sweetener.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement for adults, take one (1) softgel daily, preferably with a meal or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
7500 mcg per serving Form: natural Beta-Carotene

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Carotenoid Blend

816 mcg per serving Form: D. salina

Other (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Safflower Oil, Yellow Beeswax, Annatto extract, Zinc Oxide, Radish powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar Drug Interactions

Want to check YOUR meds against Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
459Drugs
9 Major 450 Moderate

Ingredients driving the most interactions

Vitamin A 387
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) interact with 459 drugs. Click any drug to see the details.

2 of the 5 ingredients in Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) interact with drugs. Each result below shows which ingredient is responsible. Vitamin A Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU), from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar: Common Questions

Does Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) by Solgar interact with any medications?
Yes. Based on its ingredients, Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) has a known interaction with 459 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The data on zeaxanthin and lutein supplements in pregnancy and breastfeeding is not well studied, so there isn't enough information to say either way. Vitamin A at normal recommended amounts is likely safe in pregnancy, but high doses are possibly unsafe and have been linked to birth defects — so keep doses moderate. Talk with your doctor or pharmacist for personalized advice before starting.
Can I take this if I'm already on another vitamin supplement?
Not automatically. If you're taking any other supplement or medication that contains vitamin A, retinoids, or additional carotenoids, you could end up with too much vitamin A in your system, which can be toxic. Check with your pharmacist or doctor first.
What does zeaxanthin do in the body?
Zeaxanthin is a yellow carotenoid pigment that accumulates in the retina — the light-sensing tissue at the back of your eye. It's possibly effective for slowing age-related macular degeneration, a condition that can blur central vision over time.
Will this actually prevent or treat macular degeneration?
Zeaxanthin and lutein are both possibly effective for age-related macular degeneration, which means there's some evidence they may help, but the science isn't definitive. Talk with your eye doctor about whether this product makes sense for your individual situation.
Can I take this with my diabetes medication?
Zeaxanthin might theoretically increase the risk of low blood sugar (hypoglycemia) if you take antidiabetes drugs. Check with your doctor or pharmacist before adding it to your routine — they can monitor your blood sugar and adjust your medication if needed.
What are the inactive ingredients, and are there fillers?
The softgel contains soybean oil, safflower oil, gelatin, vegetable glycerin, beeswax, annatto extract, zinc oxide, and radish powder — these are inactive ingredients that help deliver the active carotenoids. That's a standard set of ingredients for this type of supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU) label
Go deeper

The Full Monographs Behind Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Naturally Sourced Beta-Carotene 7,500 mcg (25,000 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team