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Dietary supplement

Uva-Ursi Ingredients & Drug Interactions

by Herb Pharm

Uva-Ursi label
See full label image
Liquid Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva-Ursi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva-Ursi is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva-Ursi liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva-Ursi by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva-Ursi by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva-Ursi by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: uva-ursi liquid extract. Uva-ursi is a plant traditionally used for urinary tract support.

The extract also contains inactive ingredients — certified organic grain alcohol, distilled water, vegetable glycerine, and uva-ursi extractives — which help preserve and deliver the active ingredient.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health support.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, kidney health.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva-ursi is limited. For urinary tract infections (UTIs), it's rated as possibly ineffective based on the data we hold.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence to say whether it works or not. If you're considering it for any of these conditions, talk with your doctor about whether it's right for you.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva-ursi is generally well tolerated at low doses used short-term. The most common side effects are mild — diarrhea, nausea, stomach upset, and vomiting.

At very high doses (20 grams or more of dried herb), serious effects like convulsions, delirium, shortness of breath, and tinnitus have been reported, and doses of 30 grams or higher may be fatal. The safety data advises against using uva-ursi during pregnancy because it may stimulate the uterus and safety hasn't been established.

There also isn't enough information to use it safely while breastfeeding, so you should avoid it then too. Because of the risk of toxicity with prolonged use, this herb is meant for short-term use only.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any Moderate-severity medications: those metabolized by CYP2C19 or CYP3A4 liver enzymes, drugs cleared by glucuronidation, lithium for mood disorders, or medications that acidify your urine. Also mention any P-glycoprotein substrates you're on.

Most of these interactions are theoretical — not confirmed in humans — but your healthcare provider can weigh the risk for your specific situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva-ursi may be worth considering if you're interested in short-term urinary tract support, though the evidence for effectiveness is weak. If you take any medications — especially for mood, heart rhythm, or blood pressure — you'll want to check them against this product first, since uva-ursi may change how your body clears them.

Avoid it if you're pregnant or breastfeeding. Talk it over with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 29, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva-Ursi, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700014339
Net contents 2 fl. Oz.; 59.2 mL
Market status On market
Date entered into DSLD Dec 29, 2014
DSLD ID 40075
Product type Botanical With Nutrients
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva-Ursi by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
40 Drop(s)
Maximum serving Sizes:
40 Drop(s)
UPC/BARCODE
090700014339
IngredientAmount% DV
Uva-Ursi liquid extract0 NP--

Other ingredients: certified organic grain Alcohol, distilled Water, Vegetable Glycerine, Uva-Ursi extractives

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep Out of the Reach of Children

Caution: Consult a qualified midwife or physician before taking during pregnancy.

Keep Out of the Reach of Children

General Statements

whole leaf

Liquid Herbal Extract

To assure thorough extraction of Uva-Ursi's bioactive compounds, the leaves are hand-harvested at its optimal potency, are carefully shade-dried and cleaned of superfluous stems, and is then promptly extracted.

FDA Statement of Identity

HERBAL SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE Shake Well Before Using Two to four times per day take 30 to 40 drops in a little water.

General

005

Formulation

We prepare our Uva-Ursi Extract from the leaf of Arctostaphylos uva-ursi shrubs which are Custoim Wildcrafted(TM) in their natural habitat &/or Certified Organically Grown.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva-Ursi by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva-Ursi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva-Ursi by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size40 Drop(s) Dosage formLiquid Amounts shown are per serving.

Uva-Ursi liquid extract

Interacts with
803 drugs
0 NP per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva-Ursi liquid extract monograph & interactions

Other (inactive) ingredients: Certified organic grain Alcohol, Distilled Water, Vegetable Glycerine, Uva-Ursi extractives. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva-Ursi by Herb Pharm Drug Interactions

Want to check YOUR meds against Uva-Ursi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva-Ursi liquid extract 803

Individual Drug Interactions

The ingredients in Uva-Ursi interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva-Ursi interact with drugs. Each result below shows which ingredient is responsible. Uva-Ursi liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva-Ursi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva-Ursi liquid extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva-Ursi liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva-Ursi, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Uva-Ursi by Herb Pharm: Common Questions

Does Uva-Ursi by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Uva-Ursi has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva-Ursi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is uva-ursi safe to use during pregnancy?
No. The safety data advises against it during pregnancy because it may stimulate the uterus and its safety hasn't been established. Talk with your doctor about alternatives if you need urinary tract support while pregnant.
Can I breastfeed while taking uva-ursi?
There isn't enough information to know if it's safe while breastfeeding, so you should avoid it. Check with your doctor or pharmacist if you need urinary support during this time.
What side effects should I watch for?
Most people tolerate low doses well short-term. You might notice diarrhea, nausea, stomach upset, or vomiting. At very high doses, serious effects like convulsions and delirium are rare but possible. Use only as directed and for short-term periods.
Does uva-ursi actually work for urinary tract infections?
Based on the evidence we hold, it's rated as possibly ineffective for UTIs. The data doesn't support its use for this purpose, so talk with your doctor about proven treatments instead.
Why do I need to check my medications before taking this?
Uva-ursi may slow how your liver breaks down certain drugs, potentially raising their levels in your body. This matters most if you take heart, mood, or blood pressure medications. Your doctor or pharmacist can tell you if any of your drugs are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva-Ursi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva-Ursi label
Go deeper

The Full Monographs Behind Uva-Ursi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva-Ursi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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